DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ETHR and CCHa2-R

DIOPT Version :9

Sequence 1:	NP_001287439.1	Gene:	ETHR / 42523	FlyBaseID:	FBgn0038874	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001356958.1	Gene:	CCHa2-R / 35535	FlyBaseID:	FBgn0033058	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	389	Identity:	109/389 - (28%)
Similarity:	187/389 - (48%)	Gaps:	49/389 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPQIP------SYIRTTAMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLV 59
            ::|.:|      :|| .|.::  .:|.::||:||..:.|:..:.:.|||..|.::.:|::|||||
  Fly    57 IVPYVPVLDRPETYI-VTVLY--TLIFIVGVLGNGTLVIIFFRHRSMRNIPNTYILSLALADLLV 118

  Fly    60 LLVCTPTVLVEVNTRPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVC 124
            :|||.|...: |.|: |:|.....||:...|.:......||.|:.|:|.|||.||..||:.  :.
  Fly   119 ILVCVPVATI-VYTQ-ESWPFERNMCRISEFFKDISIGVSVFTLTALSGERYCAIVNPLRK--LQ 179

  Fly   125 TKGRAILICVLAWGIAALFTSP-ILW--VAEYKLAEYIDGSSVAVCLTQAISDWTLAFFLMT--I 184
            ||...:...|:.|.:|.|...| :|:  :..|.:.......::.||  ....|...|.|::.  .
  Fly   180 TKPLTVFTAVMIWILAILLGMPSVLFSDIKSYPVFTATGNMTIEVC--SPFRDPEYAKFMVAGKA 242

  Fly   185 SVFFVVPFVTLVVLYGIIARNL-VSNRAAMLRARPTKPELSLKARKQVVLMLGAVVLSFFVCLLP 248
            .|::::|...:..||.::|:.| :|.|......:..:.....:||..|..|:.|.|:.||:|..|
  Fly   243 LVYYLLPLSIIGALYIMMAKRLHMSARNMPGEQQSMQSRTQARARLHVARMVVAFVVVFFICFFP 307

  Fly   249 FRVLTLWI-ILSTDQTLHDLGLVRYYSLLY---FCRIMLYLNSAMNPILYNLMSTKFRRGFKR-L 308
            :.|..||. ...|.:...|    .::::|.   ||  ..:|||.:||:....:|..||:.|.| |
  Fly   308 YHVFELWYHFYPTAEEDFD----EFWNVLRIVGFC--TSFLNSCVNPVALYCVSGVFRQHFNRYL 366

  Fly   309 CQDAGRLLLELVTLGRRKEDSSRGRRGTLSLGMGTNTNT-NTNSSNATGATSSSI---LSRSSN 368
            |         .:.:.|:    ...|:.:.:.||..||:. :...|...|.|:.::   |.|:||
  Fly   367 C---------CICVKRQ----PHLRQHSTATGMMDNTSVMSMRRSTYVGGTAGNLRASLHRNSN 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_001287439.1	7tm_4	18..>143	CDD:304433	44/124 (35%)
		7tm_1	27..294	CDD:278431	81/276 (29%)
		7tm_4	<102..307	CDD:304433	59/214 (28%)
CCHa2-R	NP_001356958.1	7tmA_Bombesin_R-like	70..362	CDD:320593	90/306 (29%)
		TM helix 1	71..97	CDD:320593	8/28 (29%)
		TM helix 2	104..130	CDD:320593	11/26 (42%)
		TM helix 3	142..172	CDD:320593	11/29 (38%)
		TM helix 4	182..202	CDD:320593	4/19 (21%)
		TM helix 5	234..259	CDD:320593	6/24 (25%)
		TM helix 6	285..315	CDD:320593	12/29 (41%)
		TM helix 7	330..355	CDD:320593	8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438994
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840