DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ETHR and GHSR

DIOPT Version :9

Sequence 1:	NP_001287439.1	Gene:	ETHR / 42523	FlyBaseID:	FBgn0038874	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_940799.1	Gene:	GHSR / 2693	HGNCID:	4267	Length:	366	Species:	Homo sapiens

Alignment Length:	361	Identity:	116/361 - (32%)
Similarity:	183/361 - (50%)	Gaps:	40/361 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLPQIPSYIRTTAMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVCTP 65
            :|...|:.:.......|:.:.::|:.||::..:|:.:.:::|.:||::|::::.:|||:.| |.|
Human    34 LLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFL-CMP 97

  Fly    66 TVLVEV-NTRPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRA 129
            ..||.: ..||  |..|..:||...||..:..:|:||||.|:|.|||:|||.||:|..|.||||.
Human    98 LDLVRLWQYRP--WNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRV 160

  Fly   130 ILICVLAWGIAALFTSPILWVAEYKLAEYIDGSSVAVCLTQ--AISDWTLAFFLMTISVFFVVPF 192
            .|:..:.|.:|.....||..:...:.....|......|...  |:....|...:...|:||.:|.
Human   161 KLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPV 225

  Fly   193 VTLVVLYGIIARNLVSNRA--AMLRARPTKPELSLKARKQVVLMLGAVVLSFFVCLLPFRVLTLW 255
            ..|.|||.:|.|.|...|.  |::.|     .|..:..||.|.||..||.:|.:|.|||.|....
Human   226 FCLTVLYSLIGRKLWRRRRGDAVVGA-----SLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYL 285

  Fly   256 IILSTDQ-TLHDLGLVRYYSLLYFCRIMLYLNSAMNPILYNLMSTKFR------RGFKRLCQDAG 313
            ...|.:. :|....:.:|.:|:.|  ::.||::|:||||||:||.|:|      .||:...|
Human   286 FSKSFEPGSLEIAQISQYCNLVSF--VLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQ--- 345

  Fly   314 RLLLELVTLGRRKEDSSRGRRGTLSLGMGTNTNTNT 349
               .:|.||   |::|||.         .|.::.||
Human   346 ---RKLSTL---KDESSRA---------WTESSINT 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_001287439.1	7tm_4	18..>143	CDD:304433	48/125 (38%)
		7tm_1	27..294	CDD:278431	92/272 (34%)
		7tm_4	<102..307	CDD:304433	75/215 (35%)
GHSR	NP_940799.1	7tmA_GHSR	44..334	CDD:320259	101/299 (34%)
		TM helix 1	44..71	CDD:320259	5/26 (19%)
		TM helix 2	78..103	CDD:320259	11/25 (44%)
		TM helix 3	116..146	CDD:320259	15/29 (52%)
		TM helix 4	158..180	CDD:320259	7/21 (33%)
		TM helix 5	209..238	CDD:320259	10/28 (36%)
		TM helix 6	256..286	CDD:320259	13/29 (45%)
		TM helix 7	302..327	CDD:320259	12/26 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H57161
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940