Protein Alignment ETHR and Trhr

DIOPT Version :10

• Sequence 1: NP_650960.2
• Gene: ETHR / 42523
• FlyBaseID: FBgn0038874
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_037179.1
• Gene: Trhr / 25570
• RGDID: 3904
• Length: 412
• Species: Rattus norvegicus
• Alignment Length: 351
• Identity: 109/351 - (31%)
• Similarity: 174/351 - (49%)
• Gaps: 75/351 - (21%)

  Fly     3 PQIPSYI--RTTAMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVC-T 64
            ||:...:  :...:...:||..||:|||:||.:|:::||.||.:||.:|.:|::|||:||:.. .
  Rat    16 PQVAVALEYQVVTILLVVVICGLGIVGNIMVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGL 80

  Fly    65 PTVLVEVNTRPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRA 129
            |.:...:.   .:||.|:..|..:.:::....:||..:|.|.:.|||.|||.|:||.::||..||
  Rat    81 PNITDSIY---GSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRA 142

  Fly   130 ILICVLAWGIAALFTSPILW--VAEYKLAEYIDGSSVAVCLTQAISDWTLAFFLMTISVFFVVPF 192
            ..|.:..|...:::.  :||  :.:..::.|.| :.|..|..:...::....:||...||:|:|.
  Rat   143 KKIIIFVWAFTSIYC--MLWFFLLDLNISTYKD-AIVISCGYKISRNYYSPIYLMDFGVFYVMPM 204

  Fly   193 VTLVVLYGIIARNLVSNRAAMLRARPTKPELSLK---------------------------ARKQ 230
            :...||||.|||.|      .|...|:.|:.:.|                           :|||
  Rat   205 ILATVLYGFIARIL------FLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQ 263

  Fly   231 VVLMLGAVVLSFFVCLLPFRVLTL------------WIILSTDQTLHDLGLVRYYSLLYFCRIML 283
            |..||..||:.|.:..:|:|.|.:            |.:|                   ||||.:
  Rat   264 VTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLL-------------------FCRICI 309

  Fly   284 YLNSAMNPILYNLMSTKFRRGFKRLC 309
            |||||:||::|||||.|||..|::||
  Rat   310 YLNSAINPVIYNLMSQKFRAAFRKLC 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_650960.2	7tmA_ETH-R	11..305	CDD:320128	104/335 (31%)
		TM helix 1	12..38	CDD:320128	10/25 (40%)
		TM helix 2	45..70	CDD:320128	10/25 (40%)
		TM helix 3	85..115	CDD:320128	9/29 (31%)
		TM helix 4	128..149	CDD:320128	4/20 (20%)
		TM helix 5	176..205	CDD:320128	12/28 (43%)
		TM helix 6	226..256	CDD:320128	13/68 (19%)
		TM helix 7	273..298	CDD:320128	14/24 (58%)
Trhr	NP_037179.1	7tmA_TRH-R	36..331	CDD:320126	102/325 (31%)
		TM helix 2	60..85	CDD:320126	10/24 (42%)
		TM helix 3	98..128	CDD:320126	9/29 (31%)
		TM helix 4	141..162	CDD:320126	6/22 (27%)
		TM helix 5	188..217	CDD:320126	12/28 (43%)
		TM helix 6	259..289	CDD:320126	12/29 (41%)
		TM helix 7	299..324	CDD:320126	16/43 (37%)