DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ETHR and Mlnr

DIOPT Version :9

Sequence 1:	NP_001287439.1	Gene:	ETHR / 42523	FlyBaseID:	FBgn0038874	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_852029.3	Gene:	Mlnr / 252859	RGDID:	621262	Length:	352	Species:	Rattus norvegicus

Alignment Length:	331	Identity:	107/331 - (32%)
Similarity:	162/331 - (48%)	Gaps:	54/331 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IPSYIRTTAMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVC-TPTVL 68
            :|.| :..::|..:::..||:|||.||.:|::.::||...||.:|.:|::|||||||.. .|.|
  Rat    18 LPEY-KVVSVFLVLLVCTLGIVGNAMVILVVLTSRDMHTPTNCYLVSLALADLLVLLAAGLPNV- 80

  Fly    69 VEVNTRPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILIC 133
              .::....|:.|...|..:.:.:....:.|..:|||.:.|||.|||.||:|..|||..||..|.
  Rat    81 --SDSLVGHWIYGRAGCLGITYFQYLGINVSSFSILAFTVERYIAICHPLRAQTVCTVARAKRII 143

  Fly   134 VLAWGIAALFTSPILWVAEYKLAEY-IDGSSVAVCLTQAISDWTLAFFLMTISVFFVVPFVTLVV 197
            ...||:.:|:.  :||   :.|.:. :..:....|..:......|..:|:..:|||:.|.:..:|
  Rat   144 AGIWGVTSLYC--LLW---FFLVDLNVRDNQRLECGYKVPRGLYLPIYLLDFAVFFIGPLLVTLV 203

  Fly   198 LYGIIARNL----VSNRA--------AMLRARPTKPELSLKARKQVVLMLGAVVLSFFVCLLPFR 250
            |||:|.|.|    :|..|        ....|.|.....:..:|||...||..|||.|.|...|:|
  Rat   204 LYGLIGRILFQSPLSQEAWQKERQPHGQSEAAPGNCSRAKSSRKQATRMLAVVVLLFAVLWTPYR 268

  Fly   251 VLTL------------WIILSTDQTLHDLGLVRYYSLLYFCRIMLYLNSAMNPILYNLMSTKFRR 303
            .|.|            |::|                   |||..:|.|||:||::|:|||.|||.
  Rat   269 TLVLLNSFVAQPFLDPWVLL-------------------FCRTCVYTNSAVNPVVYSLMSQKFRA 314

  Fly   304 GFKRLC 309
            .|.:||
  Rat   315 AFLKLC 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_001287439.1	7tm_4	18..>143	CDD:304433	47/125 (38%)
		7tm_1	27..294	CDD:278431	91/292 (31%)
		7tm_4	<102..307	CDD:304433	75/229 (33%)
Mlnr	NP_852029.3	7tm_4	37..>161	CDD:304433	48/131 (37%)
Mlnr	NP_852029.3	7tm_1	39..305	CDD:278431	91/292 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4666
eggNOG	1	0.900	-	-		E33208_3BFHW
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4038
OMA	1	1.010	-	-		QHG46032
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002547
OrthoInspector	1	1.000	-	-		otm46368
orthoMCL	1	0.900	-	-		OOG6_104289
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1670
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770