Protein Alignment ETHR and Trhr

DIOPT Version :10

• Sequence 1: NP_650960.2
• Gene: ETHR / 42523
• FlyBaseID: FBgn0038874
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_038724.1
• Gene: Trhr / 22045
• MGIID: 98824
• Length: 393
• Species: Mus musculus
• Alignment Length: 348
• Identity: 111/348 - (31%)
• Similarity: 170/348 - (48%)
• Gaps: 85/348 - (24%)

  Fly    10 RTTAMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVC-TPTVLVEVNT 73
            :...:...::|..||:|||:||.:|:::||.||..||.:|.:|::|||:||:.. .|.:...:.
Mouse    25 QVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIY- 88

  Fly    74 RPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILICVLAWG 138
              .:||.|:..|..:.:::....:||..:|.|.:.|||.|||.|:||.::||..||..|.:..|.
Mouse    89 --GSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWA 151

  Fly   139 IAALFTSPILW-------VAEYKLAEYIDGSSVAVCLTQAIS-DWTLAFFLMTISVFFVVPFVTL 195
            ..:::.  :||       ::.||       ::|.|.....|| ::....:||...||:|||.:..
Mouse   152 FTSIYC--MLWFFLLDLNISTYK-------NAVVVSCGYKISRNYYSPIYLMDFGVFYVVPMILA 207

  Fly   196 VVLYGIIARNLVSNRAAMLRARPTKPE----------------LSLKA-----------RKQVVL 233
            .||||.|||.|      .|...|:.|:                |:|.|           ||||..
Mouse   208 TVLYGFIARIL------FLNPIPSDPKENSKMWKNDSIHQNKNLNLNATNRCFNSTVSSRKQVTK 266

  Fly   234 MLGAVVLSFFVCLLPFRVLTL------------WIILSTDQTLHDLGLVRYYSLLYFCRIMLYLN 286
            ||..||:.|.:..:|:|.|.:            |.:|                   ||||.:|||
Mouse   267 MLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLL-------------------FCRICIYLN 312

  Fly   287 SAMNPILYNLMSTKFRRGFKRLC 309
            ||:||::|||||.|||..|::||
Mouse   313 SAINPVIYNLMSQKFRAAFRKLC 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_650960.2	7tmA_ETH-R	11..305	CDD:320128	108/341 (32%)
		TM helix 1	12..38	CDD:320128	9/25 (36%)
		TM helix 2	45..70	CDD:320128	10/25 (40%)
		TM helix 3	85..115	CDD:320128	9/29 (31%)
		TM helix 4	128..149	CDD:320128	4/20 (20%)
		TM helix 5	176..205	CDD:320128	13/28 (46%)
		TM helix 6	226..256	CDD:320128	13/52 (25%)
		TM helix 7	273..298	CDD:320128	14/24 (58%)
Trhr	NP_038724.1	7tmA_TRH-R	26..331	CDD:320126	108/341 (32%)
		TM helix 1	27..53	CDD:320126	9/25 (36%)
		TM helix 2	60..85	CDD:320126	10/24 (42%)
		TM helix 3	98..128	CDD:320126	9/29 (31%)
		TM helix 4	141..162	CDD:320126	6/22 (27%)
		TM helix 5	188..217	CDD:320126	13/28 (46%)
		TM helix 6	259..289	CDD:320126	12/29 (41%)
		TM helix 7	299..324	CDD:320126	16/43 (37%)