DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ETHR and Trhr

DIOPT Version :9

Sequence 1:	NP_001287439.1	Gene:	ETHR / 42523	FlyBaseID:	FBgn0038874	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_038724.1	Gene:	Trhr / 22045	MGIID:	98824	Length:	393	Species:	Mus musculus

Alignment Length:	348	Identity:	111/348 - (31%)
Similarity:	170/348 - (48%)	Gaps:	85/348 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RTTAMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVC-TPTVLVEVNT 73
            :...:...::|..||:|||:||.:|:::||.||..||.:|.:|::|||:||:.. .|.:...:.
Mouse    25 QVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIY- 88

  Fly    74 RPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILICVLAWG 138
              .:||.|:..|..:.:::....:||..:|.|.:.|||.|||.|:||.::||..||..|.:..|.
Mouse    89 --GSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWA 151

  Fly   139 IAALFTSPILW-------VAEYKLAEYIDGSSVAVCLTQAIS-DWTLAFFLMTISVFFVVPFVTL 195
            ..:::.  :||       ::.||       ::|.|.....|| ::....:||...||:|||.:..
Mouse   152 FTSIYC--MLWFFLLDLNISTYK-------NAVVVSCGYKISRNYYSPIYLMDFGVFYVVPMILA 207

  Fly   196 VVLYGIIARNLVSNRAAMLRARPTKPE----------------LSLKA-----------RKQVVL 233
            .||||.|||.|      .|...|:.|:                |:|.|           ||||..
Mouse   208 TVLYGFIARIL------FLNPIPSDPKENSKMWKNDSIHQNKNLNLNATNRCFNSTVSSRKQVTK 266

  Fly   234 MLGAVVLSFFVCLLPFRVLTL------------WIILSTDQTLHDLGLVRYYSLLYFCRIMLYLN 286
            ||..||:.|.:..:|:|.|.:            |.:|                   ||||.:|||
Mouse   267 MLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLL-------------------FCRICIYLN 312

  Fly   287 SAMNPILYNLMSTKFRRGFKRLC 309
            ||:||::|||||.|||..|::||
Mouse   313 SAINPVIYNLMSQKFRAAFRKLC 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_001287439.1	7tm_4	18..>143	CDD:304433	46/125 (37%)
		7tm_1	27..294	CDD:278431	96/314 (31%)
		7tm_4	<102..307	CDD:304433	80/251 (32%)
Trhr	NP_038724.1	7tm_4	33..>165	CDD:304433	48/136 (35%)
Trhr	NP_038724.1	7tm_1	42..320	CDD:278431	96/314 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4744
eggNOG	1	0.900	-	-		E33208_3BFHW
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4121
Isobase	1	0.950	-	0	Normalized mean entropy	S5306
OMA	1	1.010	-	-		QHG46032
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002547
OrthoInspector	1	1.000	-	-		otm44270
orthoMCL	1	0.900	-	-		OOG6_104289
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4203
SonicParanoid	1	1.000	-	-		X1670
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.750