Protein Alignment ETHR and npr-35

DIOPT Version :10

• Sequence 1: NP_650960.2
• Gene: ETHR / 42523
• FlyBaseID: FBgn0038874
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_001023088.2
• Gene: npr-35 / 183681
• WormBaseID: WBGene00016842
• Length: 384
• Species: Caenorhabditis elegans
• Alignment Length: 350
• Identity: 101/350 - (28%)
• Similarity: 171/350 - (48%)
• Gaps: 26/350 - (7%)

  Fly    13 AMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVCTPTVLVEVNTRPET 77
            |:||      .||:||..|.:.:...|::..:|:..:.:|::|||.:|.:|.||.|  :|:....
 Worm    41 AVFF------TGVLGNTFVVLAVWAHKNLNITTDYLILSLALADLFILWICLPTTL--INSIFTE 97

  Fly    78 WVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILICVLAWGIAAL 142
            |:.|...|:...:...:.:.|||.|::|::.:||.|||..||......:.....:....|.:||:
 Worm    98 WLWGQFFCRLSTWANASTSFASVYTLVAVTADRYLAICHTLKYNTSWDREYTKYVIFAVWLVAAI 162

  Fly   143 FTSPILWVAEYKLAEYIDGS-SVAVCLTQAISDWTLAFFLMTISVFFVVPFVTLVVLYGIIARNL 206
            |..| .|. .|.|..:.:|| ...:|.:|  :|..|.|..:.:.:.|:|||..:..||..|...:
 Worm   163 FGIP-NWY-NYDLIVWQEGSYGYRLCTSQ--TDQKLYFLFVNLLLAFIVPFGLISGLYTRIFITV 223

  Fly   207 VSNRAAMLRARPTKPELSLKARKQVVLMLGAVVLSFFVCLLPFRVLTLWIILSTDQTLHDLGLVR 271
            .::|:..:.||..:..:.|:    |..|:..|::.|..|.||...:..:.....||. .||..:.
 Worm   224 STHRSLAVDARAREDRVKLR----VATMMLTVIIVFACCWLPLYCIFTYFFFFADQR-SDLFQIT 283

  Fly   272 YYSLLYFCRIMLYLNSAMNPILYNLMSTKFRRGFKRLCQDAGRLLLELV--TLGRRKEDSSRGRR 334
            ...:....:.|..|:|::|||:|...|.|:||.||.:.....:...|.|  |:.||   .|||.:
 Worm   284 SMLIRPIFQWMSLLSSSLNPIIYIAYSHKYRRAFKSILLMPCKTRYERVRSTILRR---HSRGFK 345

  Fly   335 GTLSLGMGTNTNTNTNSSNATGATS 359
            .|.::.|   :|..|..:|..||:|
 Worm   346 STATISM---SNFGTEPTNLGGASS 367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_650960.2	7tmA_ETH-R	11..305	CDD:320128	83/292 (28%)
		TM helix 1	12..38	CDD:320128	8/24 (33%)
		TM helix 2	45..70	CDD:320128	10/24 (42%)
		TM helix 3	85..115	CDD:320128	9/29 (31%)
		TM helix 4	128..149	CDD:320128	5/20 (25%)
		TM helix 5	176..205	CDD:320128	9/28 (32%)
		TM helix 6	226..256	CDD:320128	7/29 (24%)
		TM helix 7	273..298	CDD:320128	7/24 (29%)
npr-35	NP_001023088.2	7tm_GPCRs	33..317	CDD:475119	83/292 (28%)
		TM helix 1	35..59	CDD:410628	8/23 (35%)
		TM helix 2	68..90	CDD:410628	8/21 (38%)
		TM helix 3	106..128	CDD:410628	5/21 (24%)
		TM helix 4	151..167	CDD:410628	5/16 (31%)
		TM helix 5	194..217	CDD:410628	7/22 (32%)
		TM helix 6	245..267	CDD:410628	6/21 (29%)
		TM helix 7	285..310	CDD:410628	7/24 (29%)