Protein Alignment ETHR and npr-34

DIOPT Version :10

• Sequence 1: NP_650960.2
• Gene: ETHR / 42523
• FlyBaseID: FBgn0038874
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_497057.2
• Gene: npr-34 / 175131
• WormBaseID: WBGene00013187
• Length: 613
• Species: Caenorhabditis elegans
• Alignment Length: 536
• Identity: 121/536 - (22%)
• Similarity: 202/536 - (37%)
• Gaps: 169/536 - (31%)

  Fly    15 FFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVCTPTVLVEVNTRPETWV 79
            |..:.:.|:|.:||.||..|:.:.|.|||.|||||.:||.|||.::..|.|.:.::..:  .||.
 Worm    77 FLYLTVFLVGTIGNSMVIFVVNRFKRMRNVTNIFLASLSTADLCLIWFCVPIMFMKYMS--HTWS 139

  Fly    80 LGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILICVLAWGIAALFT 144
            :|...|.:|.:::......||||:..|||||:.||..|::..:..:.|||..:.:|.|..:|:..
 Worm   140 MGRFACYSVHYIQQFTCFCSVLTMTMISFERFLAIAYPMRNIWFSSIGRAKKVILLIWMSSAVLA 204

  Fly   145 SPILWVAEYKLAEYIDGSSVAVC--------LTQAISDWTLAFFLMTISVFFVVPFVTLVVLYG- 200
            .|.....:|:....:.|..|..|        |....:....|:.:..:.:..:.|.:|:.:.|.
 Worm   205 VPTAVRMDYETNLSLSGQRVHWCRRRFPAQFLGYPRTSLNKAYAMYQLLLLIIFPVLTMSICYAR 269

  Fly   201 -------------IIARNLVS-NRAA--------------MLRARPTK-PELSLKA--------- 227
                         |:::.:|: ::||              :..:|..| ...::|:
 Worm   270 VSAIVYKSSKDRVILSQAMVAFSKAATDAVTFSGYSAIPMITTSRNLKTANTTIKSYSNHRNNRV 334

  Fly   228 ----RKQVVLMLGAVVLSFFVCLLPFRVLTLWIILSTDQTLHDLGLVRYYSLLYFCR-------- 280
                :||:|.||.::|..:.||.||..|         |:.|...|        |.||
 Worm   335 AEANKKQIVQMLISIVCMYTVCWLPTIV---------DELLTSFG--------YICRTSNTQTLK 382

  Fly   281 -------IMLYLNSAMNPILYNLMSTKFRRGFKRLCQDAGRLLLELVTLGRRKE-----DSSRGR 333
                   .:.|..|.:|||||..:|..||..||             ....|.|.     :..|.|
 Worm   383 HMRMGFNALTYCQSCINPILYAFISQNFRSTFK-------------TAYSRMKSRLQGVEEMRSR 434

  Fly   334 RGTLSLGMGTNTNTNTNSSNATGATSSSILSRSSNRRCSEDISRTRLKIEMQMPCGSDLEAMAML 398
            .|:.|                    |:|::|..:..|.                .||....:.:.
 Worm   435 MGSCS--------------------SASMMSTRNQHRI----------------YGSSFNTLTVP 463

  Fly   399 QHSTLGKGIARRVSDSRL-------------MPLRNHQP---RRHKPQ----ISFD--------- 434
            ..|.:...::|.||...|             .|:....|   .||:|:    :|.|
 Worm   464 GRSMITPNMSRDVSQLSLCRPTSQMSFCRPKSPMAGDSPSTFMRHRPRSPTDVSHDSGRPRSPTD 528

  Fly   435 -EESLEENKRSEAKIP 449
             .:|.:.::||.:..|
 Worm   529 LSQSTKPSRRSSSIRP 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_650960.2	7tmA_ETH-R	11..305	CDD:320128	91/355 (26%)
		TM helix 1	12..38	CDD:320128	8/22 (36%)
		TM helix 2	45..70	CDD:320128	12/24 (50%)
		TM helix 3	85..115	CDD:320128	12/29 (41%)
		TM helix 4	128..149	CDD:320128	6/20 (30%)
		TM helix 5	176..205	CDD:320128	5/42 (12%)
		TM helix 6	226..256	CDD:320128	12/42 (29%)
		TM helix 7	273..298	CDD:320128	10/39 (26%)
npr-34	NP_497057.2	7tmA_GPRnna14-like	75..414	CDD:320132	91/355 (26%)
		TM helix 1	75..100	CDD:320132	8/22 (36%)
		TM helix 2	107..132	CDD:320132	12/24 (50%)
		TM helix 3	145..175	CDD:320132	12/29 (41%)
		TM helix 4	188..209	CDD:320132	6/20 (30%)
		TM helix 5	244..269	CDD:320132	4/24 (17%)
		TM helix 6	337..367	CDD:320132	12/38 (32%)
		TM helix 7	382..407	CDD:320132	7/24 (29%)