DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ETHR and nmur-2

DIOPT Version :9

Sequence 1:	NP_001287439.1	Gene:	ETHR / 42523	FlyBaseID:	FBgn0038874	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_493666.2	Gene:	nmur-2 / 173398	WormBaseID:	WBGene00019616	Length:	403	Species:	Caenorhabditis elegans

Alignment Length:	419	Identity:	118/419 - (28%)
Similarity:	198/419 - (47%)	Gaps:	68/419 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QIPSYIRTTAMFFC----IV---------IMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIA 55
            :|..|:.:|....|    ||         |.|||:.||:...|||...|.|.|.||.:|.:|:::
Worm    12 EITEYVLSTLGERCQSAGIVIPTVIIYGTIFLLGLFGNICTCIVIAANKSMHNPTNYYLFSLAVS 76

  Fly    56 DLLVLLVCTPTVLVEVNTRPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKA 120
            |::.|::..|....:.......:.....:|||..|:....::||::.|...||||:.|||.||::
Worm    77 DIIALILGLPMEFYQSLDYSYPYRFSEGICKARAFLIEFTSYASIMIICCFSFERWLAICHPLRS 141

  Fly   121 GYVCTKGRAILICVLAWGIAALFTSPILWVAEY-KL-----AEY--------IDGSSVA----VC 167
            ....|..||.::.:|||.|:.:...||.::.:. ||     |:|        .||..|.    ..
Worm   142 KIFSTLWRANVLIILAWTISFVCALPIAFIVQINKLPLPEDAKYQPWTNKVSTDGIFVLHTEFCA 206

  Fly   168 LTQAISDWTLAFFLMTISVFFVVPFVTLVVLYGIIARNLVSNRAAMLRARPTKPELSLKARKQVV 232
            :.|:..|......:...:||||:|.:.:|::|..||..|.|:...:...:..|...: |:.:.|:
Worm   207 MNQSRPDQQKMIIIFAFTVFFVIPAIAIVIMYAHIAVQLESSEIDLKGDKMVKKRRN-KSNRTVL 270

  Fly   233 LMLGAVVLSFFVCLLPF---RVLTLWIILSTDQTLHD----LGLVRYYSLLYFCRIMLYLNSAMN 290
            .||.:||::||:|.|||   |:|:::...|...|:..    |.::.:| :..||   .|.|||.|
Worm   271 KMLLSVVITFFICWLPFHIQRLLSVYTTWSETTTISPPVQFLSMIVFY-ISGFC---YYSNSAAN 331

  Fly   291 PILYNLMSTKFRRGFKRLCQDAGRLLLELVTLGRRKEDSSRGRRGTLSLGMGTNTNTNTNSSNAT 355
            |||||::|.|:|..|.|..  .|..:...|..|.::...|:                  ..|::|
Worm   332 PILYNILSQKYRSAFCRTI--LGDHIANFVFKGHQRPGQSK------------------RCSSST 376

  Fly   356 GATSSSILSRSSNRRCSEDISRTRLKIEM 384
            .|...::::|.|.|     :.:...|:|:
Worm   377 EAEQRTLMTRGSVR-----VDKPHRKLEV 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_001287439.1	7tm_4	18..>143	CDD:304433	44/133 (33%)
		7tm_1	27..294	CDD:278431	88/291 (30%)
		7tm_4	<102..307	CDD:304433	74/229 (32%)
nmur-2	NP_493666.2	7tmA_capaR	32..346	CDD:320262	98/318 (31%)
		TM helix 1	34..58	CDD:320262	9/23 (39%)
		TM helix 2	67..89	CDD:320262	6/21 (29%)
		TM helix 3	107..129	CDD:320262	6/21 (29%)
		TM helix 4	152..168	CDD:320262	4/15 (27%)
		TM helix 5	216..239	CDD:320262	6/22 (27%)
		TM helix 6	267..292	CDD:320262	11/24 (46%)
		TM helix 7	314..339	CDD:320262	13/28 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940