DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ETHR and Trhr2

DIOPT Version :9

Sequence 1:	NP_001287439.1	Gene:	ETHR / 42523	FlyBaseID:	FBgn0038874	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_573465.1	Gene:	Trhr2 / 170732	MGIID:	2177284	Length:	382	Species:	Mus musculus

Alignment Length:	334	Identity:	102/334 - (30%)
Similarity:	165/334 - (49%)	Gaps:	57/334 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IPSYIRTTAMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVC-TPTVL 68
            :|.| :..::...:::..:|:|||.||.:|::.::||...||.:|.:|::|||:|||.. .|.|
Mouse    18 LPEY-KVVSVLLVLLVCTVGIVGNAMVVLVVLTSRDMHTPTNCYLVSLALADLIVLLAAGLPNV- 80

  Fly    69 VEVNTRPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILIC 133
              .::....|:.||..|..:.:.:....:.|..:|||.:.|||.|||.|::|..|||..||..|.
Mouse    81 --SDSLVGHWIYGHAGCLGITYFQYLGINVSSCSILAFTVERYIAICHPMRAQTVCTVARARRII 143

  Fly   134 VLAWGIAALFTSPILWVAEYKLAEY-IDGSSVAVCLTQAISDWTLAFFLMTISVFFVVPFVTLVV 197
            ...||:.:|:.  :||   :.|.:. :..:....|..:......|..:|:..:|||:.|.:..:|
Mouse   144 AGIWGVTSLYC--LLW---FFLVDLNVRDNQRLECGYKVSRGLYLPIYLLDFAVFFIAPLLGTLV 203

  Fly   198 LYGIIARNLVS---NRAAMLRARP------------TKPELSLKARKQVVLMLGAVVLSFFVCLL 247
            |||.|.|.|..   ::.|..:.|.            ::.:.|:.:|||...||..:||.|.|...
Mouse   204 LYGFIGRILFQSPLSQEAWQKERQSHGQSEGTPGNCSRSKSSMSSRKQATRMLAVIVLLFAVLWT 268

  Fly   248 PFRVLTL------------WIILSTDQTLHDLGLVRYYSLLYFCRIMLYLNSAMNPILYNLMSTK 300
            |:|.|.|            |::|                   |||..:|.|||:||::|:|||.|
Mouse   269 PYRTLVLLNSFLARPFLDPWVLL-------------------FCRTCVYTNSAINPVIYSLMSQK 314

  Fly   301 FRRGFKRLC 309
            ||..|.:||
Mouse   315 FRAAFLKLC 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_001287439.1	7tm_4	18..>143	CDD:304433	45/125 (36%)
		7tm_1	27..294	CDD:278431	88/295 (30%)
		7tm_4	<102..307	CDD:304433	72/232 (31%)
Trhr2	NP_573465.1	7tmA_TRH-R	33..319	CDD:320126	97/312 (31%)
		TM helix 2	57..82	CDD:320126	12/27 (44%)
		TM helix 3	95..125	CDD:320126	9/29 (31%)
		TM helix 4	138..159	CDD:320126	8/25 (32%)
		TM helix 5	182..211	CDD:320126	11/28 (39%)
		TM helix 6	214..277	CDD:320126	16/62 (26%)
		TM helix 7	287..312	CDD:320126	13/43 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4744
eggNOG	1	0.900	-	-		E33208_3BFHW
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4121
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46032
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002547
OrthoInspector	1	1.000	-	-		otm44270
orthoMCL	1	0.900	-	-		OOG6_104289
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1670
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770