DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ETHR and nmur2

DIOPT Version :9

Sequence 1:	NP_001287439.1	Gene:	ETHR / 42523	FlyBaseID:	FBgn0038874	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	XP_002940961.1	Gene:	nmur2 / 100498226	XenbaseID:	XB-GENE-6046084	Length:	397	Species:	Xenopus tropicalis

Alignment Length:	303	Identity:	100/303 - (33%)
Similarity:	156/303 - (51%)	Gaps:	30/303 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVCTPTVLVEV-NTRPETWVLGHE 83
            |.|:||:||.:|.:||:|..:||..||.:|.:|:::||||||:..|..:.|: :..|  ::.|..
Frog    54 IFLIGVIGNTLVCLVILKHHNMRTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWSNYP--FLFGAW 116

  Fly    84 MC--KAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILICVLAWGIAALFTSP 146
            .|  |.|.|.  ||..||:|::..:|.|||.||..|.:|....|:.||:.|.|..|..:.||:.|
Frog   117 GCYFKTVLFE--TVCFASILSVTTVSVERYVAIIHPFQAKLKSTRSRALKILVTLWIFSILFSIP 179

  Fly   147 ILWVAEYKLAEYIDGSSV---AVC-LTQAISDWTLAFFLMTIS-VFFVVPFVTLVVLY---GIIA 203
            ........|..:.:||.:   |.| :.|.:  |.....:...| :|:::|...:.|||   ||..
Frog   180 NTSTHGILLQYFPNGSLIPDSATCTVVQPL--WIYNCIIQVTSLLFYILPMGVISVLYCLMGIKL 242

  Fly   204 RNLVSNRAAMLRARPTKPELSLKARKQVVLMLGAVVLSFFVCLLPFRVLTLWIILSTDQT---LH 265
            |...|..|..:.....:|     :||.:..||..:|:.|.:|..||.|..|:.....|.|   .:
Frog   243 RGDHSLEADKMSVNVQRP-----SRKSITKMLFVLVMVFGICWAPFHVDRLFFSFVLDWTEPLAN 302

  Fly   266 DLGLVRYYSLLYFCRIMLYLNSAMNPILYNLMSTKFRRGFKRL 308
            ...|....|.::|     ||:||:||::|||:|.:||..|:.:
Frog   303 AFNLTHVVSGVFF-----YLSSAVNPLIYNLLSRRFRSAFQNV 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_001287439.1	7tm_4	18..>143	CDD:304433	49/125 (39%)
		7tm_1	27..294	CDD:278431	89/280 (32%)
		7tm_4	<102..307	CDD:304433	65/215 (30%)
nmur2	XP_002940961.1	7tmA_NMU-R2	45..337	CDD:320479	99/298 (33%)
		TM helix 1	45..72	CDD:320479	9/17 (53%)
		TM helix 2	79..105	CDD:320479	11/25 (44%)
		TM helix 3	118..148	CDD:320479	14/31 (45%)
		TM helix 4	160..182	CDD:320479	8/21 (38%)
		TM helix 5	212..241	CDD:320479	7/28 (25%)
		TM helix 6	260..290	CDD:320479	12/34 (35%)
		TM helix 7	305..330	CDD:320479	12/29 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940