DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ETHR and trhr3

DIOPT Version :9

Sequence 1:	NP_001287439.1	Gene:	ETHR / 42523	FlyBaseID:	FBgn0038874	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	XP_002933212.1	Gene:	trhr3 / 100489565	XenbaseID:	XB-GENE-6492473	Length:	404	Species:	Xenopus tropicalis

Alignment Length:	348	Identity:	112/348 - (32%)
Similarity:	172/348 - (49%)	Gaps:	70/348 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LPQIPSYIRTTAMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVCTPT 66
            :|||...::...:...::|..:|:.||:||.:|:::||.|...||.:|.:|:||||:|||...
Frog    25 MPQIALEVQVVTISLVLLICGVGIAGNIMVVLVVLRTKHMMTPTNCYLVSLAIADLIVLLAAG-- 87

  Fly    67 VLVEVNTRPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAIL 131
             |..::....:||.|:..|..:.:::....:.|..:|.|.:.|||.|||..:||.::||..||..
Frog    88 -LPNISEVVASWVYGYVGCLCITYLQYLGINISACSITAFTVERYIAICHSIKAQFICTVSRAKK 151

  Fly   132 ICVLAWGIAALFTSPILW-----VAEYKLAEYIDGSSVAVCLTQAISDWTLAFFLMTISVFFVVP 191
            |....|...:::.  ::|     :.|.|.|   ||..|......:.:.:|..:|| ..::|:|:|
Frog   152 IIAFVWFFTSMYC--VMWFFLVDITEVKFA---DGVQVNCGYRVSRNLYTPIYFL-DFTIFYVIP 210

  Fly   192 FVTLVVLYGIIARNLVSNRAAMLRARPT-----------KPELSLK-----------ARKQVVLM 234
            .|...||||:|||.|..|   .|.:.|.           ||..|:|           :||||..|
Frog   211 LVLATVLYGLIARILFMN---PLPSNPQDLSRMSSKHYGKPYNSIKLSGKGNKNTASSRKQVTKM 272

  Fly   235 LGAVVLSFFVCLLPFRV------------LTLWIILSTDQTLHDLGLVRYYSLLYFCRIMLYLNS 287
            |..||:.|.:..:|:|.            |.:|.:|                   |||:.:||||
Frog   273 LAVVVILFALLWMPYRTLVVVNSFMDPPYLNVWFVL-------------------FCRLCIYLNS 318

  Fly   288 AMNPILYNLMSTKFRRGFKRLCQ 310
            |:|||:|||||.|||..||.||:
Frog   319 AINPIIYNLMSQKFRAAFKNLCK 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_001287439.1	7tm_4	18..>143	CDD:304433	43/124 (35%)
		7tm_1	27..294	CDD:278431	95/305 (31%)
		7tm_4	<102..307	CDD:304433	79/243 (33%)
trhr3	XP_002933212.1	7tmA_TRH-R	34..336	CDD:320126	105/332 (32%)
		TM helix 1	35..61	CDD:320126	7/25 (28%)
		TM helix 2	68..93	CDD:320126	12/27 (44%)
		TM helix 3	105..135	CDD:320126	8/29 (28%)
		TM helix 4	148..169	CDD:320126	5/22 (23%)
		TM helix 5	195..224	CDD:320126	13/29 (45%)
		TM helix 6	264..294	CDD:320126	11/29 (38%)
		TM helix 7	304..329	CDD:320126	16/43 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I3999
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002547
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1670
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.050