Protein Alignment ETHR and ghsrb

DIOPT Version :10

• Sequence 1: NP_650960.2
• Gene: ETHR / 42523
• FlyBaseID: FBgn0038874
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: XP_002666717.1
• Gene: ghsrb / 100332193
• ZFINID: ZDB-GENE-090327-1
• Length: 365
• Species: Danio rerio
• Alignment Length: 335
• Identity: 116/335 - (34%)
• Similarity: 170/335 - (50%)
• Gaps: 42/335 - (12%)

  Fly     6 PSYIRTTAMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVCTPTVLVE 70
            |..|.|.....|..:.|:|:.||::..:|:.|.||||.:||::|.:::::|||:.| |.|..|..
Zfish    38 PVPILTGITVTCSFLFLVGIAGNLLTILVVTKYKDMRTTTNLYLCSMALSDLLIFL-CMPLDLYR 101

  Fly    71 V-NTRPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILICV 134
            | ..||  |..|.|:||...||..:..::::|.|.|:|.|||:|||.||:|..:.|:||...:.:
Zfish   102 VWRYRP--WNFGDELCKLFQFVSESCTYSTILNITALSVERYFAICFPLRAKVIVTRGRVKGVIL 164

  Fly   135 LAWGIAALFTSPIL-------------W-VAEYKLAEYIDGSSVAVCLTQAISDWTLAFFLMTIS 185
            |.|.:|.....||.             | ..|.|..||            ||....|...:...|
Zfish   165 LLWTVALCSAGPIFILVGVEHENGTNAWETNECKATEY------------AIRSGLLTMMVWVSS 217

  Fly   186 VFFVVPFVTLVVLYGIIARNLVSNRAAMLRARPTKPELSL-KARKQVVLMLGAVVLSFFVCLLPF 249
            |||.:|.:.|.|||.:|.|.|...     :..|..|..|. |:.||.|.||..|||:|.:|.|||
Zfish   218 VFFFLPVLCLTVLYSLIGRRLWRR-----KENPVGPISSRDKSNKQTVKMLAVVVLAFVLCWLPF 277

  Fly   250 RVLTLWIILSTDQTLHDLGLV-RYYSLLYFCRIMLYLNSAMNPILYNLMSTKFRRG---FKRLCQ 310
            .|....:..|::.....:..: .|.:|:.|  ::.||::|:||||||:||.|||..   ..|:.:
Zfish   278 HVGRYLVSKSSEANSPVISQISEYCNLVSF--VLFYLSAAINPILYNIMSKKFRSAACKLFRVKR 340

  Fly   311 DAGRLLLELV 320
            ..||.|..:|
Zfish   341 APGRSLQSIV 350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_650960.2	7tmA_ETH-R	11..305	CDD:320128	109/313 (35%)
		TM helix 1	12..38	CDD:320128	6/25 (24%)
		TM helix 2	45..70	CDD:320128	10/24 (42%)
		TM helix 3	85..115	CDD:320128	12/29 (41%)
		TM helix 4	128..149	CDD:320128	6/33 (18%)
		TM helix 5	176..205	CDD:320128	11/28 (39%)
		TM helix 6	226..256	CDD:320128	15/29 (52%)
		TM helix 7	273..298	CDD:320128	11/24 (46%)
ghsrb	XP_002666717.1	7tm_GPCRs	43..332	CDD:475119	109/310 (35%)
		TM helix 1	45..69	CDD:410628	6/23 (26%)
		TM helix 2	78..99	CDD:410628	8/21 (38%)
		TM helix 3	116..138	CDD:410628	6/21 (29%)
		TM helix 4	161..177	CDD:410628	3/15 (20%)
		TM helix 5	209..232	CDD:410628	9/22 (41%)
		TM helix 6	260..282	CDD:410628	12/21 (57%)
		TM helix 7	300..325	CDD:410628	12/26 (46%)