DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5892 and CG10182

DIOPT Version :9

Sequence 1:	NP_650959.2	Gene:	CG5892 / 42522	FlyBaseID:	FBgn0038873	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_651158.1	Gene:	CG10182 / 42780	FlyBaseID:	FBgn0039091	Length:	699	Species:	Drosophila melanogaster

Alignment Length:	709	Identity:	334/709 - (47%)
Similarity:	467/709 - (65%)	Gaps:	23/709 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAKVSVVVLILGLAVTSALDFGPEINEGNELDAQDYQRLNKVRHLSEQFFSYYKNVTLDDL-VPE 64
            |..:..||.:.||.:.||    ..:|:.:.|  .|.||:::::.|:..|....|:..:::| ..|
  Fly     1 MVNIVGVVFLCGLGLISA----GRLNDEDVL--SDLQRVSQLKGLALDFVGQVKDFDVEELSTLE 59

  Fly    65 GRLPTVSDLQCYADFAQLTAGLASGSLWAYRMIDSWGSIPSGILKGHLKDLGHYDECIAIEQSAA 129
            .|:|:..|:.|.:|...||.||.||..||.:|.|||||||||:|.|::.|||::|||:.|....:
  Fly    60 TRVPSQEDMLCLSDLTALTTGLQSGQYWALKMFDSWGSIPSGLLTGNMYDLGNFDECLNINHGVS 124

  Fly   130 SGSTLLGKYCLASLPLQQLLGNVGRMM-NVQTAVCFPASCSATNMDTLLRRVLKQLVGLELNSNQ 193
            .|.|:.||||..|:.|.|.||....:: :.:||.|.|||||||.|:|.:..|.|||:.:.:.|:.
  Fly   125 LGRTIQGKYCFLSVSLAQALGVQSSIIGHFKTATCLPASCSATYMNTFMGMVTKQLLNVSIPSSV 189

  Fly   194 NLVSENSCKTSERDAYDGGAIAAIVILSVFGGAVIISTFYDYFLCADQNKLPAILKVFSARANSR 258
            ..:||:||:|||...:||..|..||||||.|..|.:.|.:||.|..:|::||.|:||||||.|||
  Fly   190 MSISESSCQTSESVPWDGLTIFMIVILSVMGSLVALFTLWDYCLGKNQDQLPTIVKVFSARVNSR 254

  Fly   259 SLFRIT-TKPNPNVIECLHGLRGMSLIWVCFGHDFIISMTSPNINLYDVYTWAKTPFKDIIQEGV 322
            :||||. ...:||||:||||:|.:||:||.|.|.::::..:.|||::...:|.:||:...|..|.
  Fly   255 ALFRIVEVNSSPNVIDCLHGIRCLSLMWVVFCHQYVMAALASNINIFHAISWEETPYASFILHGF 319

  Fly   323 FAVDSFFFISGLLVAMVALRSMEKAKGKLNIPLMYLHRYLRLTPIVAVSILLYWKLLPHLGDGPL 387
            |:|||||.:.|||||::.||.|::.|||||:|||||||.:|:.|::|::|::|.||:|.:.|||.
  Fly   320 FSVDSFFVLGGLLVALIPLRMMDRTKGKLNVPLMYLHRLIRIVPLLAIAIVMYLKLMPIVADGPR 384

  Fly   388 YGNWNFDSYDRCEGNWYWTLLYVQNYATDSECLAHTWYLAIDTQLYIIAPILLIIVYKWGKKGAA 452
            :|:....:.| ||..||||||:|.|| |:.:||.|||||::|.||:|::||:||.:||||||.||
  Fly   385 FGSGYSGTVD-CENGWYWTLLFVNNY-TEEKCLGHTWYLSVDMQLFILSPIMLIALYKWGKKAAA 447

  Fly   453 VVLLLLLGLTAYLFSIIVINNYSLISGGGGGGPDDYSEDLDHYTHNRASGWLVGFLFGYFLHTIR 517
            .:.:|::.|:..||:.|::|.|||:.....   .|..:||...||..|:.||.||||||.||..|
  Fly   448 GIFVLIVLLSGCLFATIMVNKYSLVLKNFS---MDAQKDLYFATHTHATPWLTGFLFGYSLHLNR 509

  Fly   518 GKAIKLSRPAVWIGWITCLAFLFTCIFAMYPYGTGKSKTLPTLNEAFYVSLSRIAWPLGLSWVVF 582
            ||..:||:...|.|||.|||.:||.|||:|||.......|.|..||.|.:|:|:.|.:.|.||:|
  Fly   510 GKKFQLSKVVAWSGWILCLAMIFTSIFALYPYAKWTGPDLSTFAEASYYTLTRVGWCMALCWVIF 574

  Fly   583 ACMQGYGGLANSFLTSPLWQPLSKLSFCAYMGHLFIQNLNAGRTRVNTYFSNYDIMLRFWQDFGF 647
            |||.||||||||||:||||||||:||:..||.|:|.|.:|....|.|:|||||.|||.||..|||
  Fly   575 ACMNGYGGLANSFLSSPLWQPLSRLSYSVYMWHMFFQEINIRSMRTNSYFSNYTIMLNFWSTFGF 639

  Fly   648 TVLLAYVMYILIEAPCGGLESLILPNRRPAPQPKVQA---------AEPSKEEIPSPVD 697
            .||.||||:::||||.|||:..:.|.::..|..|.::         .|..|...|:|.:
  Fly   640 AVLFAYVMHLVIEAPFGGLDYFLRPKQKTPPLVKQKSQIDDNGHNNLEELKVTTPTPAE 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5892	NP_650959.2	NRF	90..203	CDD:214781	53/113 (47%)
		Acyl_transf_3	272..656	CDD:280013	200/383 (52%)
		OafA	277..685	CDD:224748	207/416 (50%)
CG10182	NP_651158.1	NRF	85..186	CDD:214781	48/100 (48%)
		Acyl_transf_3	269..645	CDD:280013	197/380 (52%)
		OafA	300..655	CDD:224748	189/359 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458066
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	11	10.900