DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5892 and CG3106

DIOPT Version :9

Sequence 1:	NP_650959.2	Gene:	CG5892 / 42522	FlyBaseID:	FBgn0038873	Length:	738	Species:	Drosophila melanogaster
Sequence 2:	NP_001285060.1	Gene:	CG3106 / 31909	FlyBaseID:	FBgn0030148	Length:	742	Species:	Drosophila melanogaster

Alignment Length:	786	Identity:	265/786 - (33%)
Similarity:	394/786 - (50%)	Gaps:	109/786 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VSVVVLILGLAVTSALDFGPEINEGN-------------------ELDAQDYQRLNKVRHLSEQF 49
            |..|||::..||      |.:....|                   .|.:|..:..|:.   :.|.
  Fly     7 VLAVVLLIATAV------GAQDTSSNYLLTGHSTPLASSFAHQFFTLASQSAELANRT---NTQV 62

  Fly    50 FSYYKNVTLDDLVPEGRLPTVSDLQCYADFAQLTAGLASGSLWAYRMIDSWGSIPSGILKGHLKD 114
            ...|::...||.:            |..|...:...:.:...||....|:||.:|.|:..||...
  Fly    63 IQTYEDRNYDDEL------------CDRDINLIRDSINNLEEWALEFPDTWGRLPMGLFWGHTIS 115

  Fly   115 LGHYDECIAIEQSAASGSTLLGKYCLASLPLQQLLGNV-------GRMMNVQT-------AVCFP 165
            :|.|:||:|  .|:...:.:.|:||||||.:.....:|       .|:...||       .:|.|
  Fly   116 MGQYEECVA--ASSTHTTEIRGQYCLASLNITTFYQSVKKRGEEFSRISYKQTDPEVFELGICVP 178

  Fly   166 ASCSATNMDTLLRRVLKQLVGLE-LNSNQNLVSENSCKTSERDAYDGGAIAAIVILSVFGGAVII 229
            .:|||...:.||:..:....|.: :.||..:|:|..||........|..|.||:..|:....::.
  Fly   179 KTCSAAKTEKLLKYAITHFYGQDVMESNYTMVTEARCKYDAPIELRGIDIFAIIFFSLIIFFMVA 243

  Fly   230 STFYDYFLCADQNKLPAILKVFSARANSRSLFRITTKPNPNVIECLHGLRGMSLIWVCFGHDFII 294
            |:.|||...........:|..||...|:..:|.:....|||||.||:|||..|::||.|||.::.
  Fly   244 SSVYDYIQTRKGAPKKPLLIAFSVLTNAPKIFTVKKVNNPNVIHCLNGLRCFSMMWVVFGHGYMT 308

  Fly   295 SMTSPNINLYDVYTWAKTPFKDIIQEGVFAVDSFFFISGLLVAMVALRSMEKAKGKLNIPLMYLH 359
            ....|:||....|||.:||:..::|.|...||:|||:||||:...|.|.||:.|||||||:||.|
  Fly   309 FYDLPHINKNKFYTWVQTPYSMLVQNGSLCVDTFFFMSGLLMCWGAFREMERTKGKLNIPMMYFH 373

  Fly   360 RYLRLTPIVAVSILLYWKLLPHLGDGPLYGNWNFDSYD-RCEGNWYWTLLYVQNYATD-SECLAH 422
            ||:||||:|||.:|....|..:.|.||::  :...:.| ||...|:.||:||||||.. |.|::.
  Fly   374 RYIRLTPVVAVVVLYIMSLYKYSGAGPMW--FKLGTQDKRCADTWWATLIYVQNYAFPYSICISQ 436

  Fly   423 TWYLAIDTQLYIIAPILLIIVYKWGKKG---AAVVLLLLLGLTAYLFSIIVINNYSLISGGGGGG 484
            :||||:|||||.::|:.||.::|||||.   ..:||:|.||.|   |:..::|:::|..     .
  Fly   437 SWYLAVDTQLYFLSPLFLIPLWKWGKKALVPIVIVLILCLGGT---FATFMLNDFTLFR-----V 493

  Fly   485 PD---DYSEDLDHY-THNRASGWLVGFLFGYFLHT-IRGKAIKLSRPAVWIGWITCLAFLFTCIF 544
            .|   |..:.|.:| ||.|...||:|.:|||||.| .||:.|.:|:|.|..||......:..|::
  Fly   494 QDDQVDLRQRLTYYPTHTRIPTWLIGVIFGYFLFTRNRGRQIPMSKPLVLTGWFVAFGTMLACMW 558

  Fly   545 AMYPYGTGKSKTLPTLNEAFYVSLSRIAWPLGLSWVVFACMQGYGGLANSFLTSPLWQPLSKLSF 609
            ..|......:...|.:..||:..|||.:|.|.:.|:|:||..|:|||.|.||:...:...|:|.:
  Fly   559 GPYWRILPDTPDSPLIEGAFFEPLSRTSWALSIGWIVWACYNGHGGLVNDFLSWGFFTGFSRLCY 623

  Fly   610 CAYMGHLFIQNLNAGRTRVNTYFSNYDIMLRFWQDFGFTVLLAYVMYILIEAPCGGLESLILPNR 674
            |.|:.|..:|.:||.|.:.:|:|||||.:||:|.|||.|:..:....:..|||..|:|..|.  .
  Fly   624 CMYVIHRIVQLVNAARLQTDTHFSNYDAILRWWHDFGITLTASIFATLAFEAPILGIEKAIF--G 686

  Fly   675 RPAPQPKVQAAEPSKEEIPSPVDLEKQTPESSAAIDLANDSTLATAPP---------LEGKTQLQ 730
            :|||:.            |||.:|.|..|.:         :|.|:|.|         :|.||::.
  Fly   687 KPAPKK------------PSPGELAKAAPVA---------ATSASAEPEPEAKPESVVETKTEIA 730

  Fly   731 ASEGNE 736
            ....||
  Fly   731 PVPTNE 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5892	NP_650959.2	NRF	90..203	CDD:214781	39/127 (31%)
		Acyl_transf_3	272..656	CDD:280013	166/393 (42%)
		OafA	277..685	CDD:224748	172/417 (41%)
CG3106	NP_001285060.1	NRF	91..217	CDD:214781	39/127 (31%)
		Acyl_transf_3	286..635	CDD:280013	150/358 (42%)
		OafA	289..702	CDD:224748	178/436 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458079
Domainoid	1	1.000	50	1.000	Domainoid score	I11639
eggNOG	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H129774
Inparanoid	1	1.050	178	1.000	Inparanoid score	I4016
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	1	1.000	-	-		FOG0001682
OrthoInspector	1	1.000	-	-		otm25504
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	11	10.900