Protein Alignment e and Aasdh

DIOPT Version :10

• Sequence 1: NP_524431.2
• Gene: e / 42521
• FlyBaseID: FBgn0000527
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: NP_001385951.1
• Gene: Aasdh / 364136
• RGDID: 1311135
• Length: 1099
• Species: Rattus norvegicus
• Alignment Length: 815
• Identity: 190/815 - (23%)
• Similarity: 295/815 - (36%)
• Gaps: 248/815 - (30%)

  Fly    29 QQLRHADKVALIYQPSTT-----GQGMAPSQSSYRQMNERANRAARLLVAETHGRFLQPNSDGDF 88
            |:|.|  :.|.||...|.     |....|...:|:.:...|:..:..|:|..       :..|..
  Rat     4 QELVH--QAASIYLDRTAVCFDEGNNQPPVCYTYKALLSEASELSAFLLAHC-------DLGGIR 59

  Fly    89 IVAVCMQPSEGLVTTLLAIWKAGGAYLPIDP-SFPANRIH--------HILLEAKPTLVIRDDDI 144
            .:.:..||...|.:.:|.|.:...||.|||| |.|:...|        ::|:|.:.....:..
  Rat    60 EIGLYCQPGINLPSWILGILQIPAAYAPIDPDSLPSLATHFMKKCGLKYVLVEKRQITKFKSS-- 122

  Fly   145 DAGRFQGTPTLSTTELYAKSLQL--------AGSNLLS-----------EEMLRGGNDH------ 184
                .:......|..:..|.|.|        |.:::||           ||.:.|.|..
  Rat   123 ----HETVLNYDTVSVEHKDLVLLRLHWEDGAVNSVLSDRTDKCKVNDREERVNGENGSQEKGHM 183

  Fly   185 -------IAIVLYTSGSTGVPKGVRLPHESILNRLQWQWATFPYTANEAVSVFKTALTFVDSIAE 242
                   :|.||:|||:||.||.||:||..||..:|...:.|..| .|.|....:.|||..|:.|
  Rat   184 DMRREGCLAYVLHTSGTTGTPKIVRVPHACILPNIQHFRSLFDIT-QEDVLFLASPLTFDPSVVE 247

  Fly   243 LWGPLMCGLAILVVPKAVTKDPQRLV-ALLERYKIRRLVLVPTLLR---------------SLLM 291
            ::..|..|..:|:.|.:|...|.:|. .|..|:::..|...|||||               :.|.
  Rat   248 IFVALSSGACLLISPTSVKVLPSKLADVLFSRHRVTVLQATPTLLRRFGSELMKSTVLSAHTSLR 312

  Fly   292 YLKMEGGGAAQKLLYNLQIWVCSGEPLSVSLASSFFDYFDEGVHRLYNFYGSTEVLGDVTYFACE 356
            .|.:  ||.|...|..||.|  .|:               ....:::|.||.|||....|::...
  Rat   313 VLAL--GGEAFPSLTVLQSW--RGK---------------SNRTQIFNIYGITEVSSWATFYRIP 358

  Fly   357 SK---KQLSLYDNVPIGIPLSNTVVYLLDADYRPVKNGEIGEIFASGLNLAAGYVNGRDPERFLE 418
            .:   ..:.|...|.:|.||..|||.:.|.:..||..| .|::|..|.|...          ||:
  Rat   359 EEILNSSVRLESPVQLGSPLLGTVVEVRDKNGSPVHEG-TGQVFLGGKNRIC----------FLD 412

  Fly   419 NPLAVEKKYARLYRTGDYGSLKNGSIMYEGRTDSQVKIRGHRVDLSEVEKNVAELPLVDKAIVLC 483
            ..:.|  ....:..|||:.::|.|.|.:.||.|||:|..|.|:.::.|::...||..|:...|..
  Rat   413 EEMTV--PLGTMRATGDFVTVKGGEIFFLGRKDSQIKRHGKRLSIALVQQVAEELRQVESCAVTW 475

  Fly   484 YHAGQVDQAILAFVKLRDDAPMVTEMQMEARLKDKLADYMTPQVVILEHVPLLVNGKVDRQALLK 548
            |:    .:.::.|:..:.|  :|.:...:...|...|..:...:|::..:|:..:||||...|.|
  Rat   476 YN----QEKLILFIVSKVD--LVKDYIFKELQKHLPAHALPDDMVLIGSLPVTCHGKVDVSELNK 534

  Fly   549 TYETANNNEGDSSIVLDFDYSQ------------------------VPEDLKLTARDLFETVGGV 589
            .|             ||:..||                        :|||.:|...|
  Rat   535 IY-------------LDYISSQPRNKLHGKEELWGKLQCLWKSILCLPEDPELKVPD-------- 578

  Fly   590 IGRSTRATLAPHSNFYELGGNSLNSIFTVTLLREKGYNIGISEFIAAKNLGEIIEKMAANHDAVQ 654
                       :|.|.:.||:||.|::.                     |||:
  Rat   579 -----------NSVFLDSGGDSLKSLWL---------------------LGEV------------ 599

  Fly   655 LEEESLNACPHLKMEAVPLRLEHRQEVIDIIVASFYNKADLEQWLKPGVLRTDYSDILNDIWNVL 719
               |.|...|      ||..||                         .:|.:.:.|:.|.|...:
  Rat   600 ---EKLTGAP------VPGLLE-------------------------VILSSSFLDVYNHIIQAV 630

  Fly   720 VERDLSFVVYDTNTDRIIGTALNFDARNEPEVDIK 754
            :.|:      |...||...|...|...:..|...|
  Rat   631 LTRE------DLKGDRRYTTKRKFSDPDSEETSGK 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
e	NP_524431.2	A_NRPS	34..546	CDD:341253	146/576 (25%)
		PP-binding	580..641	CDD:425746	9/60 (15%)
Aasdh	NP_001385951.1	A_NRPS_acs4	16..532	CDD:341309	143/567 (25%)
		WD40 repeat	751..786	CDD:293791
		PQQ_2	791..1011	CDD:433144
		WD40 repeat	793..847	CDD:293791
		WD40 repeat	854..898	CDD:293791
		WD40 repeat	906..932	CDD:293791
		PQQ	<964..>1079	CDD:441129