DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment e and Aasdh

DIOPT Version :9

Sequence 1:	NP_524431.2	Gene:	e / 42521	FlyBaseID:	FBgn0000527	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_609230.2	Gene:	Aasdh / 34175	FlyBaseID:	FBgn0027780	Length:	1012	Species:	Drosophila melanogaster

Alignment Length:	810	Identity:	174/810 - (21%)
Similarity:	296/810 - (36%)	Gaps:	202/810 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 AGGAYLPIDPSFPANRIHHILLEAKPTLVIRDDDIDAGRFQGTPTLSTTELYAKSLQLAGSNLLS 174
            ||..||..:.......::...|.:  .||.::|               ..||...|:.|...:.|
  Fly   116 AGVDYLVANKHLTVAPLYFTFLGS--ILVFKED---------------CRLYRVKLKSADETVQS 163

  Fly   175 EEMLRGGNDHIAIVLYTSGSTGVPKGVRLPHESIL-------NRLQWQWATFPYTANEAVSVFKT 232
            ::.|..   ::...:.|:|:||.||.:.:|:|.|.       .:|....|...|..        |
  Fly   164 KKPLPA---NMCYTISTTGTTGKPKLIHVPYECIAPNIVGLSQKLNVSMADIIYLG--------T 217

  Fly   233 ALTFVDSIAELWGPLMCGLAILVVPKAVTKDPQRLVAL-----LERYKIRRLVLVPTLLRSLLMY 292
            .:||...:.|.:..|..|..:|....::...|.::::.     |....|..|.:.|:|.|..
  Fly   218 PITFDPFVVEFFLALQNGATLLTSRHSMRDSPSKVLSALFPDNLATPGITVLQMTPSLFRQF--- 279

  Fly   293 LKMEGGGAA---QKLL---YNLQIWVCSGEPL--SVSLASSFFDYFDEGV---HRLYNFYGSTEV 346
                  ||:   .::|   .:|::.:..|||.  :|.|.:    :....|   ..:.|.||.||:
  Fly   280 ------GASSIKDRVLSGSSSLRVLLLGGEPFPSNVELVT----WMHPSVLMQKHICNIYGITEI 334

  Fly   347 LGDVTYFACESKKQL--SLYDNVPIGIPLSNTVVYLLDADYRPVKNGEIGEIFASGLNLAAGYVN 409
                   :|.|...:  ||...||:|.|:....|..::::..  :..:.||:|...:.... |:.
  Fly   335 -------SCWSLLHIVQSLQSPVPLGTPIEEDTVLRIESEDN--ETSQQGELFLGSVKRRC-YIP 389

  Fly   410 GRDPERFLENPLAVEKKYARLYR-TGDYGS-LKNGSIMYEGRTDSQVKIRGHRVDLSEVEKNVAE 472
            ..|     :...|.:......:| |||..: .::|::.|..|::..||..|:|:.|..:.:.:.:
  Fly   390 EVD-----DQANASQDDSGICFRATGDLVTRQQDGTLFYSERSNDVVKRAGNRISLGLITRKIQK 449

  Fly   473 LPLVDKAIVLCYHAGQVDQAILAFVKLRDDAPMVTEMQMEARLKDKLADY----MTPQVVILEHV 533
            . |....:..|.....:.:.|.....|...    |.:|...:..|.|:..    ...:.|.|:|.
  Fly   450 C-LPSSELTTCLWLEDLQKLICCIRTLESK----TRVQQRVQTFDILSKVSIAEQPDRFVYLQHF 509

  Fly   534 PLLVNGKVDRQALLKTYETANNNEGDSSIVLDFDYSQVPEDLKLTARDLFETVGGVIGRSTR--- 595
            |..|:||:|:|.|||           ..|.|.....|:   ||....|..|.|......:::
  Fly   510 PCNVHGKLDKQQLLK-----------MCIPLAQPAQQI---LKSYLHDRLECVEEPDDSASKKQR 560

  Fly   596 ----ATLAPHSNFYELGGNSLNSIFTVTLLREKGYNIGISEFIAAKNLGEIIEKMAANHDAVQLE 656
                |......:|.:.||.|.::|   |:.||.|..:.|                         :
  Fly   561 LDDAAPCGYDLSFRQAGGTSFHAI---TICREIGLQMCI-------------------------D 597

  Fly   657 EESLNACPHLKMEAVPLRLEHRQEVIDIIVASFYNKADLEQWLKPGVLRTDYSDILNDIWNVLVE 721
            :|..:....|..|.:|||          .|..|.:.|.|               :.|:|....||
  Fly   598 DEQRHLFEMLLDENIPLR----------TVLRFLDTAKL---------------VANNIKRKNVE 637

  Fly   722 RDLSFVVYDTNTDRIIGTALNFDARNEPEVDIKSKLLIVFEFLEFCEGPIRDNYLPKGLNQILHS 786
              .:.||....:..||       .|.|..| :|.::.....|.:..:.|:.: |..:.:....||
  Fly   638 --TAVVVSACQSGLII-------KRIEQPV-LKLQIYWKVNFEKCIDSPVTE-YEGRFICVGAHS 691

  Fly   787 FMMGTAEKLNPRENIACMHFMEHEVLRVAREKQFAGIFTTNTSPLTQQLADVYHYKTLL---NFQ 848
            .::.|   |||:..      .|:.|:::....:....|      ||:|||.|..|...|   |.|
  Fly   692 KILRT---LNPQTG------SEYSVVKLPERIECKVTF------LTEQLAMVGCYDGCLYGFNPQ 741

  Fly   849 VNEYVHSDG------SRPFGDAPDEQRAIV 872
            ....|...|      |:|...| |.:|.||
  Fly   742 TGNIVFRVGIGGLIKSQPMLTA-DGRRIIV 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
e	NP_524431.2	A_NRPS	35..546	CDD:213296	99/466 (21%)
		AA-adenyl-dom	56..481	CDD:273779	83/397 (21%)
		PP-binding	580..644	CDD:278949	14/70 (20%)
Aasdh	NP_609230.2	AA-adenyl-dom	46..443	CDD:273779	82/382 (21%)
		AFD_class_I	<168..522	CDD:302604	85/397 (21%)
		PQQ_DH_like	<728..1012	CDD:299747	14/44 (32%)
		PQQ_2	732..978	CDD:290097	12/40 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1020
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6452
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002418
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100454
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5888
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.690