DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment e and lys1

DIOPT Version :9

Sequence 1:	NP_524431.2	Gene:	e / 42521	FlyBaseID:	FBgn0000527	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_594314.1	Gene:	lys1 / 2542079	PomBaseID:	SPAP7G5.04c	Length:	1419	Species:	Schizosaccharomyces pombe

Alignment Length:	869	Identity:	213/869 - (24%)
Similarity:	347/869 - (39%)	Gaps:	239/869 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GSLPQLSIVKGLQQDFVP------------RALHRIFEEQQLRHADKVALIYQPSTTGQGMAPSQ 54
            |.:..|.::...|.:.:|            .|:..||.....:..|:..::..||.|..  ||..
pombe   249 GPIGALDLMTPTQMNVLPDPTVDLDWSGYRGAIQDIFASNAAKFPDRECIVVTPSVTID--APVT 311

  Fly    55 S-SYRQMNERANRAARLLVAETHGRFLQPNSDGDFIVAVCMQPSEGLVTTLLAIWKAGGAYLPID 118
            | :|||::|.:|..|..||.....|       || :|.|.......||..::.:.|||..:..||
pombe   312 SYTYRQIDESSNILAHHLVKNGIER-------GD-VVMVYAYRGVDLVVAVMGVLKAGATFSVID 368

  Fly   119 PSFPANRIHHILLEAKP-TLVIRDDDIDAGRFQGTPTL-----STTEL--YAKSLQLA-GSNLLS 174
            |::|..|....|..||| .||:.:   |||..  :||:     .:.||  |..:|:|| ..:|..
pombe   369 PAYPPARQIIYLSVAKPRALVVLE---DAGVL--SPTVVEYVEKSLELKTYVPALKLAKDGSLTG 428

  Fly   175 EEMLRGGNDHIAIVL--------------------YTSGSTGVPKGVRLPHESILNRLQWQWATF 219
            ..:.:|.:|.:..||                    :||||.|:||||:..|.|:.....|....|
pombe   429 GSVSKGADDILQHVLHLKSEQTGVVVGPDSTPTLSFTSGSEGIPKGVKGRHFSLAYYFDWMAQEF 493

  Fly   220 PYTANEAVSVFKTALTFVDSIA------ELWGPLMCGLAILVVPKAVTKD---PQRLVALLERYK 275
            ..:.::       ..|.:..||      :::.||..| |.|:||.|  :|   |.:|.....:||
pombe   494 NLSESD-------RFTMLSGIAHDPIQRDIFTPLFLG-ASLIVPTA--EDIGTPGQLAQWANKYK 548

  Fly   276 IRRLVLVPTLLRSLLMYLKMEGGGAAQKLLYNLQIWVCSGEPLSVSLASSFF------------- 327
            :....|.|.:.:.|          |||           :.||:. ||..:||
pombe   549 VTVTHLTPAMGQLL----------AAQ-----------ADEPIP-SLHHAFFVGDILTKRDCLRL 591

  Fly   328 DYFDEGVHRLYNFYGSTEVLGDVTYFACESKKQLSLY-----DNVPIGIPLSNTVVYLLDA-DYR 386
            ......|: :.|.||:||....|:||...::.|...:     |.:|.|..:.|..:.:::. |..
pombe   592 QVLANNVN-VVNMYGTTETQRSVSYFVVPARSQDQTFLESQKDVIPAGRGMKNVQLLVINRFDTN 655

  Fly   387 PVKN-GEIGEIFASGLNLAAGYVNGRD---PERFLENPLAVEKKYA------------------R 429
            .:.. ||:|||:.....||.||: |.|   .::||::..|...|:.                  |
pombe   656 KICGIGEVGEIYLRAGGLAEGYL-GNDELTSKKFLKSWFADPSKFVDRTPENAPWKPYWFGIRDR 719

  Fly   430 LYRTGDYGS-LKNGSIMYEGRTDSQVKIRGHRVDLSEVEKNVAELPLVDKAIVLCYHAGQVDQAI 493
            :||:||.|. |..|::...||.|.|:||||.|::|.|:..:::..|.|.:.|.|.......:..:
pombe   720 MYRSGDLGRYLPTGNVECSGRADDQIKIRGFRIELGEINTHLSRHPNVRENITLVRRDKDEEPTL 784

  Fly   494 LAFV----KLRDDAPMVTEMQ----------------MEARLKDKLADYMTPQVVI-LEHVPLLV 537
            :|::    ..:||....||.:                :...||.||..|..|.|:: |..:||..
pombe   785 VAYIVPQGLNKDDFDSATESEDIVVNGLKKYRKLIHDIREYLKTKLPSYAIPSVIVPLHKMPLNP 849

  Fly   538 NGKVDRQAL-------LKTYETANNNEGDSSIVLDFDYSQVPEDLKLTARDLFETVGGVIGRSTR 595
            |||:|:.||       |.....:::..|            |.|.|..|.||:         |...
pombe   850 NGKIDKPALPFPDTSQLAAASRSHSKHG------------VDETLTATERDI---------RDIW 893

  Fly   596 ATLAPH-------SNFYELGGNSLNSIFTVTLLREK-GYNI------------GISEFIAAKNLG 640
            ..:.||       ::|:::||:|:.:...:..||:| ..|:            |:::.|.....|
pombe   894 LRIIPHATDVNKKASFFDIGGHSILATRLIFELRKKFAVNVPLGLVFSEPTIEGLAKEIERMKSG 958

  Fly   641 EIIEKMAANHDAVQLEEESLNACPHLKMEAVPLRLEHRQ---EVIDIIVASFYNKADLEQWLKPG 702
            |:|..|....:..:..|                 :|:.:   :::|:|...|....||      |
pombe   959 EMISVMDIGKEETREPE-----------------IEYGKDALDLVDLIPKEFPTSKDL------G 1000

  Fly   703 V--LRTDYSDILNDIWNVLVERDL 724
            :  .:|.:....|....|.:.|||
pombe  1001 IDEPKTVFLTGANGYLGVFILRDL 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
e	NP_524431.2	A_NRPS	35..546	CDD:213296	165/612 (27%)
		AA-adenyl-dom	56..481	CDD:273779	137/504 (27%)
		PP-binding	580..644	CDD:278949	17/83 (20%)
lys1	NP_594314.1	alpha_am_amid	17..1417	CDD:274582	213/869 (25%)
		Condensation	<18..100	CDD:305010
		A_NRPS	311..858	CDD:213296	159/593 (27%)
		PP-binding	887..952	CDD:278949	14/73 (19%)
		SDR_e1	1006..1303	CDD:187546	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1020
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5390
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002418
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100454
Panther	1	1.100	-	-	O	PTHR44845
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7632
TreeFam	0	0.000	Not matched by this tool.
	7	6.810