DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment e and SPCC162.02c

DIOPT Version :9

Sequence 1:	NP_524431.2	Gene:	e / 42521	FlyBaseID:	FBgn0000527	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_588242.1	Gene:	SPCC162.02c / 2538929	PomBaseID:	SPCC162.02c	Length:	981	Species:	Schizosaccharomyces pombe

Alignment Length:	851	Identity:	179/851 - (21%)
Similarity:	316/851 - (37%)	Gaps:	223/851 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 SYRQMNERANRAAR----LLVAETHGRFLQPNSDGDFIVAVCMQPSEGLVTTLLAIWKAGGAYLP 116
            :|.::..|.|..|:    |.:.:|.|  :....:.||:.::            .|:|..|...:.
pombe    51 TYTELLRRVNTIAKFCDDLGLGKTVG--IHMGHELDFLCSI------------FALWATGRTCVI 101

  Fly   117 IDPSFPANRIHHILL-----------EAKPTLVIRDDDIDAGRFQGTPTLSTTELYAKSLQLAGS 170
            .:..: :.::..:|:           |.||..     ::|        ||:.|.|.:..|.
pombe   102 FNQIW-SQQVVRVLVKRLNISDLLYHEYKPKF-----EVD--------TLNATSLASLPLD---- 148

  Fly   171 NLLSEEMLRGG-NDHIAIVLYTSGSTGVPKGVRLPHESILNRLQWQWAT-FPYTANEAVSVFKTA 233
              :....:|.| ...:|::.::||||||||.:..        |..::|. :.|...|.::...|.
pombe   149 --IDAPCIRAGLEPEVALINHSSGSTGVPKSMPF--------LMKKYALGYDYGTPEFMNHLSTP 203

  Fly   234 LTFVDSIAEL---W-GPLMCGLAILVVPKAV----TKDPQRLVALLERYKIR----RLVLVPTLL 286
            :....|.|..   | ..|.|...:|....::    |.:.:|| |....|.:|    ||:::|.||
pombe   204 MVMATSFALTTLSWINALYCNGNLLYPSSSISATCTSEAERL-AWNVYYALRAGCERLIILPNLL 267

  Fly   287 RSLLMYLK-----------MEGGG---------AAQKLLYNLQIWVCSGEPLSVSLASSFFDYFD 331
            ...|..:.           :..||         ..:::|.|..|:...|  .:.|...||..|
pombe   268 VLTLQIMPDKEECFPACKLVAAGGEMVPANMYHTCKRVLPNATIYPQYG--TTESGLVSFLAY-- 328

  Fly   332 EGVHRLYNFYGSTEVLGDVTYFACESKKQLSLY--DN--VPIGIPLSNTVVYLLDADYRPVKNGE 392
            .|...|:|        .::.||..::.|:|.|.  ||  ||..|.....|..:.|....|.. |:
pombe   329 NGKDTLHN--------KELVYFPGKTVKKLMLVTEDNEAVPEKIGCEGFVCVVTDVQSEPYV-GD 384

  Fly   393 IGEIFASGLNLAAGYVNGRDPERFLENPLAVEKKYARLYRTGDYGSLKNGSIMYEGRTDSQVKIR 457
            ..|...|..:....| :|:...||.:  |||...|.        |.|   .|..:||...:||..
pombe   385 DAETIQSRNSTFINY-DGQPAVRFAD--LAVWNSYK--------GKL---GITIKGRLGRRVKRN 435

  Fly   458 GHRVDLSEVEKNVAELPLVDKAIVLCYHAGQVDQAILAFVKLRDDAPMVTEMQMEARLKDKLAD- 521
            |...||...::.|..|..|..|.....    .::.:|.:|...:....||   ::.:|..:|.|
pombe   436 GVFFDLKYFDQVVVGLKEVKDAFSFFI----FNRFVLVYVPAYNGVDPVT---LKQKLNKELRDH 493

  Fly   522 YMTPQVVILEHVPLLVNGKVDRQALLKTYETANNNEGDSSIVLDFDYSQVPEDLKLTARDLFETV 586
            ::......|..:|....||||    ||:.||.      :|..|..:..::|..|...|.::.:..
pombe   494 HLFSSCFPLADIPRNAAGKVD----LKSIETY------ASKCLSVEDQRLPVLLNPVAIEISKIA 548

  Fly   587 GGVI-GRSTRATLAPHSNFYELGGNSLNSIFTVTLLRE----KG---YNIGISEFIAAKNLGEII 643
            ..:: ..|.....||   .|..|.:|::|:.....::.    :|   ||:..:  ....::..||
pombe   549 SKILQNPSLEGKDAP---LYSCGLDSIHSVRFFHAIQSHFHLEGPIRYNMNSN--CTPNSIASII 608

  Fly   644 EKMAANHDAVQLEEESLNAC------PHLKMEAVPLRLEHRQEVIDIIVASFYNKADLEQWLKPG 702
            :|.:.|..::..|..:.:||      |  |:..:|   .:.|..:......::.:..||..:|..
pombe   609 QKKSYNVSSITYELLNEDACALSRTIP--KLSILP---TNGQYFLLTGATGYFGRRFLEYLVKLN 668

  Fly   703 V----LRTDYSDILNDIWNVLVERDLSFVVYDTNTDRIIGTALNFDARNEPEVDIKSKLLIVF-- 761
            :    |..:.||      ....||.:|.|                     |.:.|.|:.:||:
pombe   669 ISVVCLVRESSD------EAAKERLISLV---------------------PSLRISSENIIVWAA 706

  Fly   762 --EFLEFCEGPIRDNYLPKGLNQILHSFMMGTAEKLNPRENIACMHFMEHEV--LRVAREKQFAG 822
              |.:.|            ||:.....|::         ||::.::.|..||  ::..:|.:.|.
pombe   707 HVEEIRF------------GLDDAKWEFLV---------ENVSRIYHMAAEVHWMKSYQELRPAN 750

  Fly   823 IFTTNT 828
            :..|.|
pombe   751 VLGTKT 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
e	NP_524431.2	A_NRPS	35..546	CDD:213296	120/543 (22%)
		AA-adenyl-dom	56..481	CDD:273779	107/477 (22%)
		PP-binding	580..644	CDD:278949	11/71 (15%)
SPCC162.02c	NP_588242.1	CaiC	16..514	CDD:223395	118/539 (22%)
		AFD_class_I	44..518	CDD:302604	122/547 (22%)
		SDR_e1	646..912	CDD:187546	29/159 (18%)
		Lys2b	647..981	CDD:225857	29/158 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1020
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900