DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment e and Aasdh

DIOPT Version :9

Sequence 1:	NP_524431.2	Gene:	e / 42521	FlyBaseID:	FBgn0000527	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_001363933.1	Gene:	Aasdh / 231326	MGIID:	2442517	Length:	1100	Species:	Mus musculus

Alignment Length:	753	Identity:	188/753 - (24%)
Similarity:	303/753 - (40%)	Gaps:	163/753 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 EEQQLRHA----DKVALIYQPSTTGQGMAPSQSSYRQMNERANRAARLLVAETHGRFLQPNSDGD 87
            :|..||.|    |:.|:.:.   .|....|...||:.:...|:..:..|:|  |..|     .|.
Mouse     4 QELVLRTASVYMDRTAVCFD---EGNNQPPVCYSYKALLSAASELSHFLIA--HCDF-----GGI 58

  Fly    88 FIVAVCMQPSEGLVTTLLAIWKAGGAYLPIDPSFPAN---------RIHHILLEAK--------- 134
            ..:.:..||...|.:.:|.|.:...||.||||..|.:         .:.::|:|.:
Mouse    59 REIGLYCQPGINLPSWILGILQVPAAYAPIDPDSPPSLSTYFMKKCDLKYVLVEKQQLSKFKSSH 123

  Fly   135 ------PTLVIRDDDIDAGRFQGTPTLSTTELYAKSLQ---LAGSNLLSEEMLRGGNDH------ 184
                  .|:.:...|:...|........:|.|..::.|   ....:.:|.|......:|
Mouse   124 ETVLNYDTVSVEHKDLALFRLHWEDGRVSTVLGDRADQHKVTDREDRVSAESRTPEKEHMDMRHD 188

  Fly   185 --IAIVLYTSGSTGVPKGVRLPHESILNRLQWQWATFPYTANEAVSVFKTALTFVDSIAELWGPL 247
              :|.||:|||:||.||.||:||..||..:|...:.|..| .|.:....:.|||..|:.|::..|
Mouse   189 GCLAYVLHTSGTTGTPKIVRVPHACILPNIQHFRSLFDIT-QEDILFLASPLTFDPSVVEIFVSL 252

  Fly   248 MCGLAILVVPKAVTKDPQRLVALL-ERYKIRRLVLVPTLLR---------------SLLMYLKME 296
            ..|..:|:||.:|...|.:|..:| .|:::..|...|||||               :.|..|.:
Mouse   253 SSGACLLIVPTSVKVLPSKLADILFSRHRVTVLQATPTLLRRFGSELIKSTVLSAHTSLRVLAL- 316

  Fly   297 GGGAAQKLLYNLQIWVCSGEPLSVSLASSFFDYFDEGVHRLYNFYGSTEVLGDVTYFACESKKQL 361
             ||.|...|..|:.|...|...                 :::|.||.|||....|::....:...
Mouse   317 -GGEAFPSLTILKSWRGKGNRT-----------------QIFNIYGITEVSSWATFYRIPEEILN 363

  Fly   362 SLYDN---VPIGIPLSNTVVYLLDADYRPVKNGEIGEIFASGLNLAAGYVNGRDPERFLENPLAV 423
            |...:   |.:|.||..||:.:.|.:..||..| .|::|..|.|...          ||::.:.|
Mouse   364 SAVKHESPVQLGSPLLGTVIEVRDQNGSPVLEG-TGQVFLGGKNRVC----------FLDDEMTV 417

  Fly   424 EKKYARLYRTGDYGSLKNGSIMYEGRTDSQVKIRGHRVDLSEVEKNVAELPLVDKAIVLCYHAGQ 488
              ....:..|||:.::|:|.|.:.||.|||:|..|.|::::.|::...||..|:...|..|:..:
Mouse   418 --PLGTMRATGDFVTVKDGEIFFLGRKDSQIKRHGKRLNIALVQQVAEELRQVESCAVTWYNQER 480

  Fly   489 VDQAILAFVKLRDDAPMVTEMQMEARLKDKLADYMTPQVVILEHVPLLVNGKVDRQALLKTY--- 550
            :...|::.|.|..|. :..|:|     |...|..:...:|:::.:|...:||||...|.|.|
Mouse   481 LILFIVSKVDLVKDC-IFKELQ-----KHLPAHALPDDMVLIDTLPFTCHGKVDVSELNKIYLDY 539

  Fly   551 ---ETANNNEGDSSIVLDFDY--------SQVPED-LKLTARDLFETVGGVIGRSTRATLAPHSN 603
               :..|...|...:.....|        .:.||| ||:.|                     :|.
Mouse   540 ISSQPRNELHGKEELWGKLQYLWKSILCLPEDPEDTLKVPA---------------------NSV 583

  Fly   604 FYELGGNSLNSIFTVT-LLREKGYNI-GISEFIAAKNLGEII----------EKMAANHDAVQLE 656
            |.:.||:||.|:..:: :.|..|..| |:.|.|.:.:|.::.          |...||.......
Mouse   584 FLDSGGDSLKSMRLLSEIERLTGTAIPGLLEVILSSSLLDVYNHIVQAVFTPEDRKANRSYTTKR 648

  Fly   657 EESLNACPHLKMEAVPLRLE------HRQEVIDIIVAS 688
            :.| :|.|. :....|.|||      |..|...:|..|
Mouse   649 KFS-DADPE-EASGKPARLESAWPSNHAGETNSVIALS 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
e	NP_524431.2	A_NRPS	35..546	CDD:213296	144/564 (26%)
		AA-adenyl-dom	56..481	CDD:273779	124/478 (26%)
		PP-binding	580..644	CDD:278949	14/75 (19%)
Aasdh	NP_001363933.1	A_NRPS_acs4	15..532	CDD:341309	144/565 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..181		2/18 (11%)
		PP-binding	561..628	CDD:376348	20/87 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..671		7/29 (24%)
		PQQ	754..>986	CDD:224437
		assembly_YfgL	923..>1094	CDD:274511
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1020
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6452
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002418
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100454
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5888
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.690