Protein Alignment e and nrps-1

DIOPT Version :10

• Sequence 1: NP_524431.2
• Gene: e / 42521
• FlyBaseID: FBgn0000527
• Length: 879
• Species: Drosophila melanogaster
• Sequence 2: NP_499488.3
• Gene: nrps-1 / 190498
• WormBaseID: WBGene00013440
• Length: 2942
• Species: Caenorhabditis elegans
• Alignment Length: 709
• Identity: 160/709 - (22%)
• Similarity: 276/709 - (38%)
• Gaps: 209/709 - (29%)

  Fly     3 SLPQLSIV-----KGLQQDFVPRALHRIFE--------------EQQLRHADKVALIYQPSTTGQ 48
            |:|::.::     ||.......|...:||.              .||...|:..::.   :||.:
 Worm  2161 SVPEMQVILNIVLKGFNDTPCRRKHEKIFYGPRKDTPNLSIPSIYQQFFTANSTSIF---ATTSK 2222

  Fly    49 GMAPSQSSYRQMNERANRAARLLVAETHGRFL----QPNSDGDFIVAVCMQPSEGLVTTL--LAI 107
            .......:||::::.::..::        :||    ||....|.|.....:.:|   ||:  ||:
 Worm  2223 TSTTYAQAYRRLSQYSSCLSK--------KFLTSKAQPIRSDDVISVAGTRSTE---TTMKCLAV 2276

  Fly   108 WKAGGAYLPIDPSFPANRIHHILLEAKPTLVIRDDDID---AGRFQGTPTLSTTELYAKSLQLAG 169
            ...|.||||||.|:|..|        |.| :::|...:   .||....|.
 Worm  2277 QFTGAAYLPIDASYPEER--------KKT-ILKDSVFNFEYNGRVDQEPR--------------- 2317

  Fly   170 SNLLSEEMLRGGNDHIAI--------VLYTSGSTGVPKGVRLPHESILNRLQWQWATFPYTANEA 226
                        :.|.||        ::.|||:||.||.|.:..:|:||.......|...:::..
 Worm  2318 ------------HRHFAISTDYCLSYIITTSGTTGTPKSVAIGAKSLLNLFLSSTLTMKCSSSSR 2370

  Fly   227 VSVFKTALTFVDSIAE-----------LWGPLMCGLAILVVPKAVTKDPQRLVALLERYKIRRLV 280
            ...| |...|.:|:.|           ::|||..             ||......:|...|...:
 Worm  2371 TYQF-TNFVFDNSVLEVSMSIASQGTLVYGPLCF-------------DPADFEKSIETEGITHCL 2421

  Fly   281 LVPTLLRSLLMYLKMEGGGAAQKLLYNLQIWVCSGEPLSVSLASSFFDYFDEGVHRLYNFYGSTE 345
            |.|:|::|..:           ..:.||..||..||||..||..|....   |:..:.| ||.||
 Worm  2422 LFPSLVQSFNI-----------SKIKNLAYWVVGGEPLPQSLLDSALAL---GIKVIQN-YGPTE 2471

  Fly   346 VLGDVTYFACESKKQLSLYD-NVPIGIPLSNTVVYLLDADYRPVKNGEIGEIFASGLNLAAGYVN 409
                .|.||.  .|.:...| ...||:|..|:.:       |.|:..:.||:..|||.:..||:|
 Worm  2472 ----TTAFAI--AKHMKKGDAGCQIGLPAVNSKI-------RIVEGEDQGELLISGLGIMRGYLN 2523

  Fly   410 GRDPERFLENPLAVEKKYARLYRTGDYGSLKNGSIMYEGRTDSQVKIRGHRVDLSEVEKNVAE-- 472
                           :|.::.|.:||...::.|.:.:.||||:|:||||:||:|:|:||.:..
 Worm  2524 ---------------RKESQWYASGDVCRIEKGVVEFVGRTDTQIKIRGYRVELTEIEKTIESRN 2573

  Fly   473 -----LPLVDKAI--VLCYHAGQVDQAILAFVKL-RDDAPMVTEMQMEARLKDKLADYMTPQVVI 529
                 ..|.||..  :..::.|:::       || .:||            ::....|:.|..:.
 Worm  2574 GIASCKALFDKESQQIHVFYTGELE-------KLSSNDA------------REHCERYLEPHKIP 2619

  Fly   530 -----LEHVPLLVNGKVDRQALLKTYETANNNEGDSSIVLDFDYSQVPEDLKLTARDLFETVGGV 589
                 ::..||..|.|:|...|::             :|.:..:..:|..|:.....::.::...
 Worm  2620 STFNGIDKFPLTGNSKIDTLKLME-------------LVKNLPHPTLPNSLESDLSSIWTSLLNC 2671

  Fly   590 IGRSTRATLAPHSNFYELGGNSLNSIFTVTLLREK-GYNIGISEFIAAKNLGEIIEKMA 647
            ...|      |..:|:.:||:||..:....|:..| |.::.:.|.:......:::|.:|
 Worm  2672 PEPS------PSDHFFLIGGHSLLLVRLRHLIETKLGISLKVPEILQNLKFSDMLELLA 2724

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
e	NP_524431.2	A_NRPS	34..546	CDD:341253	134/555 (24%)
		PP-binding	580..641	CDD:425746	11/61 (18%)
nrps-1	NP_499488.3	PRK12316	<308..2725	CDD:237054	160/709 (23%)
		A_NRPS_acs4	2209..2641	CDD:341309	134/557 (24%)