DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment e and AASDH

DIOPT Version :9

Sequence 1:	NP_524431.2	Gene:	e / 42521	FlyBaseID:	FBgn0000527	Length:	879	Species:	Drosophila melanogaster
Sequence 2:	NP_001310819.1	Gene:	AASDH / 132949	HGNCID:	23993	Length:	1137	Species:	Homo sapiens

Alignment Length:	803	Identity:	190/803 - (23%)
Similarity:	317/803 - (39%)	Gaps:	215/803 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QQLRH------ADKVALIYQPSTTGQGMAPSQSSYRQMNERANRAARLLVAETHGRFLQPNSDGD 87
            |:|.|      .|:||:.:...   ....|...:|:.:...|:..:..|:       |..:..|.
Human     4 QELVHKAASCYMDRVAVCFDEC---NNQLPVYYTYKTVVNAASELSNFLL-------LHCDFQGI 58

  Fly    88 FIVAVCMQPSEGLVTTLLAIWKAGGAYLPIDPSFPAN---------RIHHILLEAK--------- 134
            ..:.:..||...|.:.:|.|.:...||:||:|..|.:         .:.:||:|.|
Human    59 REIGLYCQPGIDLPSWILGILQVPAAYVPIEPDSPPSLSTHFMKKCNLKYILVEKKQINKFKSFH 123

  Fly   135 ------PTLVIRDDDIDAGRFQGTPT------LSTTELYAK-SLQLAGSNLLSEEMLRGGND--- 183
                  .|..:..:|:...|.....|      ....|.|.| .::...|..::||......|
Human   124 ETLLNYDTFTVEHNDLVLFRLHWKNTEVNLMLNDGKEKYEKEKIKSISSEHVNEEKAEEHMDLRL 188

  Fly   184 -H-IAIVLYTSGSTGVPKGVRLPHESILNRLQWQWATFPYTANEAVSVFKTALTFVDSIAELWGP 246
             | :|.||:|||:||:||.||:||:.|:..:|.....|..| .|.|....:.|||..|:.|::..
Human   189 KHCLAYVLHTSGTTGIPKIVRVPHKCIVPNIQHFRVLFDIT-QEDVLFLASPLTFDPSVVEIFLA 252

  Fly   247 LMCGLAILVVPKAVTKDPQRLVALL-ERYKIRRLVLVPTLLR---------------SLLMYLKM 295
            |..|.::|:||.:|...|.:|.::| ..:::..|...|||||               :.|..|.:
Human   253 LSSGASLLIVPTSVKLLPSKLASVLFSHHRVTVLQATPTLLRRFGSQLIKSTVLSATTSLRVLAL 317

  Fly   296 EGGGAAQKLLYNLQIWVCSGEPLSVSLASSFFDYFDEGVHRLYNFYGSTEVLGDVTYFACESK-- 358
              ||.|...|..|:.|...|...                 :::|.||.|||....|.:....|
Human   318 --GGEAFPSLTVLRSWRGEGNKT-----------------QIFNVYGITEVSSWATIYRIPEKTL 363

  Fly   359 -KQLSLYDNVPIGIPLSNTVVYLLDADYRPVKNGEIGEIFASGLNLAAGYVNGRDPERFLENPLA 422
             ..|.....|.:|.||..|||.:.|.:...::.|. |::|..|.|...          ||::.:.
Human   364 NSTLKCELPVQLGFPLLGTVVEVRDTNGFTIQEGS-GQVFLGGRNRVC----------FLDDEVT 417

  Fly   423 VEKKYARLYRTGDYGSLKNGSIMYEGRTDSQVKIRGHRVDLSEVEKNVAELPLVDKAIVLCYHAG 487
            |  ....:..|||:.::|:|.|.:.||.|||:|..|.|:::..|::...||..|:...|..|:
Human   418 V--PLGTMRATGDFVTVKDGEIFFLGRKDSQIKRHGKRLNIELVQQVAEELQQVESCAVTWYN-- 478

  Fly   488 QVDQAILAFVKLRDDAPMVTEMQMEARLKDKLADYMTP-QVVILEHVPLLVNGKVDRQALLKTYE 551
              .:.::.|:..:|.:  |.|...: .|:..|..:..| ::|:::.:|...:||:|...|.|.|
Human   479 --QEKLILFMVSKDAS--VKEYIFK-ELQKYLPSHAVPDELVLIDSLPFTSHGKIDVSELNKIY- 537

  Fly   552 TANNNEGDSSIVLDFDYSQVPEDLKLTAR-DLFETVGGVIGRST------RATLAPHSNFYELGG 609
                          .:|..:..:.||:.: ||:|.: ..:.:||      ...:...|.|...||
Human   538 --------------LNYINLKSENKLSGKEDLWEKL-QYLWKSTLNLPEDLLRVPDESLFLNSGG 587

  Fly   610 NSLNSIFTVTLLREKGYNIGISEFIAAKNLGEIIEKMAANHDAVQLEEESLNACPHLKMEAVPLR 674
            :||.||   .||.|                   |||:...                    :||
Human   588 DSLKSI---RLLSE-------------------IEKLVGT--------------------SVP-- 608

  Fly   675 LEHRQEVIDIIVASFYNKADLEQWLKPGVLRTDYSDILNDIWNVLVERDLSF--------VVYDT 731
                 .:::||::|             .:|.. |:.||.   .|:.:.|::|        .:.|.
Human   609 -----GLLEIILSS-------------SILEI-YNHILQ---TVVPDEDVTFRKSCATKRKLSDI 651

  Fly   732 NTDRIIGTALN------FDARNE 748
            |.:...||:|:      |...||
Human   652 NQEEASGTSLHQKAIMTFTCHNE 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
e	NP_524431.2	A_NRPS	35..546	CDD:213296	142/566 (25%)
		AA-adenyl-dom	56..481	CDD:273779	124/479 (26%)
		PP-binding	580..644	CDD:278949	16/70 (23%)
AASDH	NP_001310819.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1020
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6452
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002418
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100454
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5888
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.690