DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3337 and ANTKMT

DIOPT Version :9

Sequence 1:	NP_001303427.1	Gene:	CG3337 / 42519	FlyBaseID:	FBgn0038871	Length:	204	Species:	Drosophila melanogaster
Sequence 2:	NP_076422.1	Gene:	ANTKMT / 65990	HGNCID:	14152	Length:	235	Species:	Homo sapiens

Alignment Length:	183	Identity:	74/183 - (40%)
Similarity:	106/183 - (57%)	Gaps:	6/183 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 GGKILIAATGGVGIGLSIVCASFVAPAFRRICL----PYVPATTEQIQNVLSFLPKNSAGKLLDI 83
            |...|:.|..|.|:....|.|..:.|.|||:.|    |||.|:..|:::|||.| :...||.:|:
Human    19 GALELLQAAAGSGLAAYAVWALLLQPGFRRVPLRLQVPYVGASARQVEHVLSLL-RGRPGKTVDL 82

  Fly    84 GSGDGRIVVAAAQHCGALKADGVELNPWLVYYSRLAALRHSVSKRTRFFRRDLWKFDIKDYNFVV 148
            ||||||||: ||..||...|.|.|||||||..:||.|.|...:....:.|:||||..::|...|.
Human    83 GSGDGRIVL-AAHRCGLRPAVGYELNPWLVALARLHAWRAGCAGSVCYRRKDLWKVSLRDCRNVS 146

  Fly   149 IFGVEQMMQDLEHKLIAECPHNTKIIACRFPLPSLEHVKIIEDGVNTVWFYDL 201
            :|....::..||.||..|.|...::::.|||||:.:.|..:.:|::.||.||:
Human   147 VFLAPSVLPLLEDKLRTELPAGARVVSGRFPLPTWQPVTAVGEGLDRVWAYDV 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3337	NP_001303427.1	Methyltransf_18	78..167	CDD:289607	40/88 (45%)
ANTKMT	NP_076422.1	N-terminal sequence (NTS). /evidence=ECO:0000303\|PubMed:31213526	1..22		1/2 (50%)
		Methyltransferase (MTase). /evidence=ECO:0000303\|PubMed:31213526	43..77		14/34 (41%)
		Pre-methyltransferase (preMT). /evidence=ECO:0000303\|PubMed:31213526	43..77		14/34 (41%)
		HemK	<65..>123	CDD:225443	32/59 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..235
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147639
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0500
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1605787at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101641
Panther	1	1.100	-	-	O	PTHR13610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.710