DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oga and oga

DIOPT Version :9

Sequence 1:	NP_650956.1	Gene:	Oga / 42518	FlyBaseID:	FBgn0038870	Length:	1019	Species:	Drosophila melanogaster
Sequence 2:	XP_009305481.1	Gene:	oga / 324487	ZFINID:	ZDB-GENE-030131-3208	Length:	927	Species:	Danio rerio

Alignment Length:	1037	Identity:	391/1037 - (37%)
Similarity:	577/1037 - (55%)	Gaps:	184/1037 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GKRQFICGVIEGFYGRPWTTEQRKDLFRKLKSMGMGSSPSYMYAPKDDYKHRAYWRELYTVEEAD 75
            |:|:||.||:|||||||||.||||:|||:.:..|:.   :|:||||||||||.:|||:|:||||:
Zfish    43 GRRKFITGVVEGFYGRPWTMEQRKELFRRQQKWGLN---TYLYAPKDDYKHRMFWREMYSVEEAE 104

  Fly    76 HLSSLIAAAKEAGITFYYALSPGLDMTYSSPKEIATLKRKLDQVAQFGCEAYALLFDDIESELSK 140
            .|::||:||||.||.|.||:|||||:|:|:.||::|||||||||..|||:::|||||||:..:..
Zfish   105 QLTTLISAAKEYGIEFIYAISPGLDITFSNQKEVSTLKRKLDQVTHFGCKSFALLFDDIDHNMCP 169

  Fly   141 ADKEVFQTFANAHVSVTNEIYTHLGSPR-FLFCPTQYCASRAVPTVQESEYLNTLGSKLNNEIDI 204
            ||||||.:||:|.|||||||:.:||.|. ||||||:||.:...|.|.:|.||.|:|.||...|::
Zfish   170 ADKEVFSSFAHAQVSVTNEIFQYLGEPEIFLFCPTEYCGTFCYPNVSQSPYLRTIGEKLLPGIEV 234

  Fly   205 LWTGDKVISKNISLESIQEITEVLRRPPCIWDNLHANDYDQKRIFMGPYSGRSPELIPHLRGVMT 269
            ||||.||:||:|::|||:|:|::|||.|.||||:|||||||||:|:|||.|||.||||.|:||:|
Zfish   235 LWTGPKVVSKDITVESIEEVTKILRRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLT 299

  Fly   270 NPNCEFYGNFVAIHSLAFWSRCSL----------DSKVNSSLSADIKLETE-NDDDLPAEFLSKN 323
            ||||||..||||||:||.|.:.::          ||: :|::|..||||.| :|::|..:.|
Zfish   300 NPNCEFESNFVAIHTLATWYKSNMNGVRKDVVMTDSE-DSTVSIQIKLENEGSDEELETDIL--- 360

  Fly   324 VYHPRLALKNAITEWLPEFFMKKEAWGPITKPQPQVQMVMPIIPIIPSINTCMSLTTTTTTSTSS 388
             |.|::|||.|:||||.||.:..:                                      .:|
Zfish   361 -YSPQIALKLALTEWLSEFGVPHQ--------------------------------------YNS 386

  Fly   389 RTVP--PTVNTTQLQALADVCVVTSSLTPISNPVMNSLVSPTKVIT--NDDIINPIPTTAASNIE 449
            |.||  .|.:||.     ||..:.:|          :||:.|.|.|  ...|::|:
Zfish   387 RQVPHSGTKSTTM-----DVPTLAAS----------TLVTSTTVTTVFQQPIMSPV--------- 427

  Fly   450 LPKKIPISVVPVPIMETKSVEASVELALDNAVFDDNEIEPNSDSVKERLELEVNLEGKQEPVANL 514
                :|:|..|..:.:.                ::.|:| ..:|.:|.:|:.|....:.|...|:
Zfish   428 ----LPLSDEPHVLGKE----------------EEEEVE-KKESDEEPMEMVVEKHDEVEDTKNV 471

  Fly   515 SVDTMLDDDSLSPLSGVVNEPMECSSSITSQVSPREEEAIKVVADDVLMESVNDVHSMHVESGTS 579
            :          ..|:.:|...|      |..:.|.:.:      .:.|.||.:...|:..:||:.
Zfish   472 N----------QILTEIVKAKM------TEDLKPMDTD------KESLTESKSPEMSIQEDSGSD 514

  Fly   580 -SPISNAEMREETEAQSDR------TNDNNTIEGEGITVDDLVLLCDLFYLPFEHGSRGHKLLVE 637
             :|:       :|:.|.::      .|:......|.:|::||.||.:|||||:|||.:..::|.|
Zfish   515 IAPM-------QTDDQLNKEVFVPGPNEKPLFITEALTLEDLTLLAELFYLPYEHGPKSVQMLKE 572

  Fly   638 FNWLKGNANVILQDRSAGGGGDAIKSDKPEVSEWHQRREQFDQLCSAVVELLIKIANCPNKEICH 702
            ||||:.|:|.:..:..|        .|..:|:||..|.|.|:::|.:|:::..:::|..|:.|.:
Zfish   573 FNWLRANSNYVSVNSKA--------KDPEKVTEWQSRAENFEEMCCSVMQMFTRLSNSANRTILY 629

  Fly   703 ELYSYMWDISGALSLLNCYVKWL---ALGHFPQNTS--SYTEGSYTWFSKGWKEAFMSGDQEPWV 762
            :||.|:|||...:|::..:|:||   .||     ||  .|...|..|........|:|||||||.
Zfish   630 DLYPYIWDIKSIISMVKSFVQWLDGRILG-----TSFYCYWTDSARWCRSQSSAQFLSGDQEPWA 689

  Fly   763 FRGGLIADLQRLMPVDSGNDLFVYKLPEQPTANYYLLRPYCNSDEQQVNDLCTRLYLQWRGELDG 827
            |||||..:.|||:|:|..||||....|..||:..|.:|||...||..:..:|..::.:   ..:|
Zfish   690 FRGGLAGEFQRLLPIDGANDLFYQPPPSMPTSKIYTIRPYFAKDESAIYKICKEMFTE---SCEG 751

  Fly   828 GRHIPFPLPANVPNIVADGLIGGYLTLSPQLCIVAYDESNRIIGYSCAALDVNIFRRNLELCWYT 892
               |.|  ....|:::.|.|:||:|||||....|..||.. :.||:...:||..|.:..:|.|..
Zfish   752 ---ISF--SDESPDLIGDRLVGGFLTLSPDYGFVLEDEEG-VCGYAMGTVDVKPFVKKCKLSWIP 810

  Fly   893 ELREKYSRDICPLEGGEEVVQLVTSLVESYHDSSGNGALDQCPVEVSGSFPAVLISGTLREAEER 957
            .::|||.:     ...|:.:.....::.|:|:..     |..|.....:||: ||...: .|:..
Zfish   811 FMQEKYIK-----PDAEKDLSEAEKMMLSFHEEE-----DGLPESFLRNFPS-LIKVDI-HAKVT 863

  Fly   958 DSGITKRMLTVLLAALRANGCFGAHVRVPQQDVAQVNFYSRIGFVDVYREEA--TKCIYMGR 1017
            |..:.|.|:..||::|:|||..||...|.|.|...::|||::|..:|.:.|.  ...|.|||
Zfish   864 DPSVAKSMMGCLLSSLKANGSHGAFCEVRQIDKRMLDFYSKLGCFEVAKMEGFPKDIIIMGR 925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oga	NP_650956.1	NAGidase	17..286	CDD:284884	173/269 (64%)
oga	XP_009305481.1	NAGidase	50..325	CDD:284884	176/277 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592544
Domainoid	1	1.000	387	1.000	Domainoid score	I768
eggNOG	1	0.900	-	-		E1_KOG3698
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8154
Inparanoid	1	1.050	676	1.000	Inparanoid score	I699
OMA	1	1.010	-	-		QHG47004
OrthoDB	1	1.010	-	-		D106930at33208
OrthoFinder	1	1.000	-	-		FOG0005508
OrthoInspector	1	1.000	-	-		otm25844
orthoMCL	1	0.900	-	-		OOG6_105534
Panther	1	1.100	-	-	LDO	PTHR13170
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2998
SonicParanoid	1	1.000	-	-		X3928
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	17	17.300