DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd5 and smyd4

DIOPT Version :9

Sequence 1:	NP_650955.1	Gene:	Smyd5 / 42517	FlyBaseID:	FBgn0038869	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_001070062.1	Gene:	smyd4 / 767654	ZFINID:	ZDB-GENE-060929-248	Length:	753	Species:	Danio rerio

Alignment Length:	451	Identity:	92/451 - (20%)
Similarity:	150/451 - (33%)	Gaps:	163/451 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KGRAMIATKNFAKDEVIFEEEPFVSRQFSWNV----------AYGY--AACDHCMRPLETVLENV 64
            |||.|:..:|....||:.|:|.:.|.....|:          .:|.  ..|.||:
Zfish   196 KGRHMLVMENKPAGEVVLEDEAYCSVLIPANIFNTGTNKAVETFGTEDRHCHHCL---------- 250

  Fly    65 RRLASDPKVEVPLLQHDPTAQWVAQFTQCPRCK-VRYCSEDCLMEAQKRYHRVAC-MGAFHSDDT 127
                               :|.:: |..||:|. .|||.|.|..:|..::|:..| :||    |.
Zfish   251 -------------------SQSLS-FVPCPKCSYARYCGESCQKDAWDQWHQWECPVGA----DL 291

  Fly   128 HPINVLNETWKKMHYPPETGSIMLIVRLMALYQQ------------STKKEEFLEQLQSFQSLIV 180
            ..|.||             |.:.|.|.|.|...:            :|.|.:...||.
Zfish   292 LAIGVL-------------GHLALRVVLKAGQTEVQMGIKNTKDHVTTYKNDSPVQLS------- 336

  Fly   181 NREQKIYHKMLGENFEQQMEQLYLAFCNAFTGEEF--------SIFKTPDAFKTLMAI------- 230
                      ||.:..:.::.     .:.|.|..:        .:.:...|.:.||||
Zfish   337 ----------LGGDCGKSLDH-----TDCFHGSSYMGIYSLLPHVAQHSPASRFLMAITMAVIYG 386

  Fly   231 -----------LGTNSQGIATSVLSQWVAKVSDLPLTD-SEKEQLDTVIDGLYA-KVGEFAGEFL 282
                       :....:|:..|    |..::|.|..|. ....||......:.| :|.|.:|..:
Zfish   387 KLQGGPPPNKWMSFKDEGVKAS----WQPEMSMLGATALRHMMQLRCNAQAITAVRVKEESGMAV 447

  Fly   283 NNE-----GSGLYLLQSKINHSCVPNACSTF-------PY-----------------SNDIVVLK 318
            .:.     .:.::.:.|.:||||.||...:|       |:                 |...|.::
Zfish   448 QSSSEIRIATAIFPVLSLLNHSCSPNTSISFTTGFQPDPHNQLGCSEGHFDHPKGSRSGVTVTVR 512

  Fly   319 ALAPIQQGEEICISYLDECMLERSR---HSRHKVLRENYVFICQCPKCRAQASDPDETSED 376
            |...:..|:||...|..    .|||   ..|.::|.|.|.|.|.|..|:...|:....:::
Zfish   513 ASKDLTAGQEILHCYGP----HRSRMEVKERQRLLLEQYFFQCVCQACQRDLSEGSPNAKE 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd5	NP_650955.1	zf-MYND	87..118	CDD:280009	11/31 (35%)
Smyd5	NP_650955.1	SET	<296..333	CDD:279228	14/60 (23%)
smyd4	NP_001070062.1	TPR_11	68..134	CDD:290150
		TPR repeat	68..96	CDD:276809
		TPR repeat	101..134	CDD:276809
		zf-MYND	246..285	CDD:280009	15/68 (22%)
		SET	<456..532	CDD:214614	16/79 (20%)
		T6SS_VasJ	<603..679	CDD:299836
		TPR_12	615..683	CDD:290160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810