DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smyd5 and smyd3

DIOPT Version :9

Sequence 1:	NP_650955.1	Gene:	Smyd5 / 42517	FlyBaseID:	FBgn0038869	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_001032477.1	Gene:	smyd3 / 569507	ZFINID:	ZDB-GENE-051120-138	Length:	380	Species:	Danio rerio

Alignment Length:	356	Identity:	79/356 - (22%)
Similarity:	125/356 - (35%)	Gaps:	112/356 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GKGRAMIATKNFAKDEVIFEEEPF---VSRQFSWNVAYGYAACDHCMRPLETVLENVRRLASDPK 72
            |||..:.|.:.....|||:..|||   |:|.|.      ..||..|::..|::
Zfish    13 GKGNGLRALREIKPGEVIYSCEPFAFCVARDFL------KTACQSCLKRGESL------------ 59

  Fly    73 VEVPLLQHDPTAQWVAQFTQCPRCK-VRYCSEDCLMEAQKRYHRVACMGAFHSDDTHPINVLNET 136
                              ::|.:|| .|||:..|..:|... |:..|....|.....|
Zfish    60 ------------------SRCSQCKTARYCNVQCQKQAWPD-HKRECKCLKHLQPRIP------- 98

  Fly   137 WKKMHYPPETGSIMLIVRLM-ALYQQSTKKEEFLEQLQSFQSLIVNREQKIYHKMLGENFEQQME 200
                     |.|:.|:.|:: .|..||...:|.|..:...||.:.:..::   |..|........
Zfish    99 ---------TDSVRLVARIIFKLLSQSESDQEELYSIAEHQSHLADMSEE---KTEGLKHLCTTL 151

  Fly   201 QLYLAFCNAFTGEEFSIFKTPDAFK--TLMAILGTNSQGIATSVLSQWVAKVSDLPLTDSEKEQL 263
            |:|||      .|...:.:.|....  :|:|.:..|.                 ..::|.|
Zfish   152 QVYLA------EENCDLSRLPSGLDPVSLLARVTCNC-----------------FSISDGE---- 189

  Fly   264 DTVIDGLYAKVGEFAGEFLNNEGSGLYLLQSKINHSCVPNACSTFPYSNDIVVLKALAPIQQGEE 328
                              |.:.|.|||...|.:||.|.||....|  ....:.|:|:..|:..||
Zfish   190 ------------------LQDVGVGLYPSMSLLNHDCQPNCIMMF--EGKRLTLRAVRVIRSAEE 234

  Fly   329 ICISYLDECMLERSRHSRH--KVLRENYVFI 357
            :.|||.|.....:.|.|:|  ::|:|:...:
Zfish   235 LTISYTDILAPSKDRRSQHWDELLKESQALL 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd5	NP_650955.1	zf-MYND	87..118	CDD:280009	9/31 (29%)
Smyd5	NP_650955.1	SET	<296..333	CDD:279228	12/36 (33%)
smyd3	NP_001032477.1	zf-MYND	49..87	CDD:280009	12/68 (18%)
		SET	<201..239	CDD:279228	13/39 (33%)
		TPR_12	276..351	CDD:290160
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810