DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smyd5 and Smyd4-3

DIOPT Version :9

Sequence 1:	NP_650955.1	Gene:	Smyd5 / 42517	FlyBaseID:	FBgn0038869	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_725048.1	Gene:	Smyd4-3 / 36234	FlyBaseID:	FBgn0033633	Length:	660	Species:	Drosophila melanogaster

Alignment Length:	372	Identity:	80/372 - (21%)
Similarity:	130/372 - (34%)	Gaps:	103/372 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KGRAMIATKNFAKDEVIFEEEPFVSRQFSWNVAYGYAACDHCMRPLETVLENVRRLASDPKVEVP 76
            :||...|:.:....|.:..|.||||....   .:....|::|.  :.||:
  Fly   249 EGRFARASADVKPGEELLVERPFVSVLLE---KFAKTHCENCF--MRTVV--------------- 293

  Fly    77 LLQHDPTAQWVAQFTQCPRC-KVRYCSEDCLMEAQKRYHRVACMGAFHSDDTHPINVLNETWKKM 140
                 |.|        |||| .|.||||.|..||.|:||:..|            .::...|:
  Fly   294 -----PVA--------CPRCADVLYCSEQCREEASKKYHKYEC------------GIVPIIWR-- 331

  Fly   141 HYPPETGSIM---LIVRLMA-------LYQQSTKKEEFL-EQLQSFQSLIVNREQKIYHKMLGEN 194
                 :|:.:   :.:|::|       |..:.|..||.. |||.|.......|..:: .:..||.
  Fly   332 -----SGASINNHIALRIIASKPLDYFLKLKPTIDEELTPEQLISLPKDDFRRVAQL-ERHQGER 390

  Fly   195 -----FEQQMEQLYLAFC---NAFTGEEFSIFKTPDAFKTLMAILGTNSQGIATSVLSQWVAKVS 251
                 |:..:...:|..|   ..:.|.|    ..||....:.:::..:.|.|..:     ..:|:
  Fly   391 QPSNFFQHVLMARFLTNCLRAGGYFGSE----PKPDEVSIICSLVLRSLQFIQFN-----THEVA 446

  Fly   252 DLPLTDSEKEQLDTVIDGLYAKVGEFAGEFLNNEGSGLYLLQSKINHSCVPNACSTFPYSNDIVV 316
            :|....|...:....|                  |..:|...:..||||.|.....|  ....:.
  Fly   447 ELHKFSSSGREKSIFI------------------GGAIYPTLALFNHSCDPGVVRYF--RGTTIH 491

  Fly   317 LKALAPIQQGEEICISYLDECMLERSRHSRHKVLRENYVFICQCPKC 363
            :.::.||:.|..|..:| .....:..|..|...|::.|.|.|.|..|
  Fly   492 INSVRPIEAGLPINENY-GPMYTQDERSERQARLKDLYWFECSCDAC 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smyd5	NP_650955.1	zf-MYND	87..118	CDD:280009	15/31 (48%)
Smyd5	NP_650955.1	SET	<296..333	CDD:279228	10/36 (28%)
Smyd4-3	NP_725048.1	TPR_11	74..143	CDD:290150
		TPR repeat	74..103	CDD:276809
		TPR repeat	108..142	CDD:276809
		TPR repeat	150..177	CDD:276809
		zf-MYND	284..323	CDD:280009	21/68 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2084
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810