Protein Alignment Smyd5 and SMYD1

DIOPT Version :10

• Sequence 1: NP_650955.1
• Gene: Smyd5 / 42517
• FlyBaseID: FBgn0038869
• Length: 393
• Species: Drosophila melanogaster
• Sequence 2: NP_938015.1
• Gene: SMYD1 / 150572
• HGNCID: 20986
• Length: 490
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 90/435 - (20%)
• Similarity: 132/435 - (30%)
• Gaps: 175/435 - (40%)

  Fly     1 MNNFEIRELPGKGRAMIATKNFAKDEVIFEEEPFVSRQFSWNVAYGYAACDHCMRPLETVLENVR 65
            |.|.|:....||||.:.|||.|...::||.|..:.:..|...|.:   .|..|.:..|
Human     6 MENVEVFTAEGKGRGLKATKEFWAADIIFAERAYSAVVFDSLVNF---VCHTCFKRQE------- 60

  Fly    66 RLASDPKVEVPLLQHDPTAQWVAQFTQCPRCK-VRYCSEDCLMEAQ----------KRYHRVACM 119
                                   :..:|.:|| ..||...|..:|.          |||.:|
Human    61 -----------------------KLHRCGQCKFAHYCDRTCQKDAWLNHKNECSAIKRYGKV--- 99

  Fly   120 GAFHSDDTHPINVLNETWKKMHYPPETGSIMLIVRLM-ALYQQSTKKEE----FLEQLQSFQSLI 179
                                   |.|  :|.|..|:| .:.::.|...|    .::.||:.....
Human   100 -----------------------PNE--NIRLAARIMWRVEREGTGLTEGCLVSVDDLQNHVEHF 139

  Fly   180 VNREQKIYHKMLGENF-------EQQMEQLYLAF------CNAFTGEEFSIFKTPDAFKTLMAIL 231
            ...|||.. ::..:.|       .||....|::.      ||.||
Human   140 GEEEQKDL-RVDVDTFLQYWPPQSQQFSMQYISHIFGVINCNGFT-------------------- 183

  Fly   232 GTNSQGIATSVLSQWVAKVSDLPLTDSEKEQLDTVIDGLYAKVGEFAGEFLNNEGSGLYLLQSKI 296
                                   |:|..         ||.|            .|.|::.....:
Human   184 -----------------------LSDQR---------GLQA------------VGVGIFPNLGLV 204

  Fly   297 NHSCVPNACSTFPYSNDIVV-----------LKALAPIQQGEEICISYLDECMLERSRHSRHKVL 350
            ||.|.||....|...|...|           |:||..|.:|||:.:||:|  .|..| ..|.:.|
Human   205 NHDCWPNCTVIFNNGNHEAVKSMFHTQMRIELRALGKISEGEELTVSYID--FLNVS-EERKRQL 266

  Fly   351 RENYVFICQCPKCRAQASD------PDETSEDDDDDDEMDDYDDD 389
            ::.|.|.|.|..|:.:..|      .|......:...||..:..|
Human   267 KKQYYFDCTCEHCQKKLKDDLFLGVKDNPKPSQEVVKEMIQFSKD 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smyd5	NP_650955.1	SET_SMYD5	3..366	CDD:380919	84/402 (21%)
		zf-MYND	87..118	CDD:460312	11/41 (27%)
SMYD1	NP_938015.1	SET_SMYD1	7..281	CDD:380924	84/402 (21%)
		zf-MYND	52..90	CDD:460312	10/67 (15%)