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Protein Alignment Smyd5 and SMYD4

DIOPT Version :9

Sequence 1:	NP_650955.1	Gene:	Smyd5 / 42517	FlyBaseID:	FBgn0038869	Length:	393	Species:	Drosophila melanogaster
Sequence 2:	NP_443160.2	Gene:	SMYD4 / 114826	HGNCID:	21067	Length:	804	Species:	Homo sapiens

Alignment Length:	461	Identity:	96/461 - (20%)
Similarity:	153/461 - (33%)	Gaps:	198/461 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PGKGRAMIATKNFAKDEVIFEEEPFVS---------------RQFSWNVAYGYAACDHCMRPLET 59
            |.|||.::|||:....|::.:|:.|||               .::...|..|...|..|::
Human   241 PLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLK---- 301

  Fly    60 VLENVRRLASDPKVEVPLLQHDPTAQWVAQFTQCPRCK-VRYCSEDCLMEAQKRYHRVAC----- 118
                 ..||:.|                     |..|. .:|||::||.:|.:.|||..|
Human   302 -----HTLATVP---------------------CDGCSYAKYCSQECLQQAWELYHRTECPLGGL 340

  Fly   119 ---MGAF------------HSDDTHPINVL--------------NETWKKMHY----PPETGSIM 150
               :|.|            ..|....|..|              |...|.::|    ..:.|:|:
Human   341 LLTLGVFCHIALRLTLLVGFEDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIV 405

  Fly   151 ------------------LIVRLMALYQQSTKKEEFL---------EQLQ--SFQSL----IVNR 182
                              .:..|:...:..:.:.:||         .||:  |.|::    |||.
Human   406 ETPIPGCDINGKYENNYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASLQAIPTERIVNS 470

  Fly   183 EQ-------------KIYHKMLGENFEQQMEQLYLAFCNAFTGEEFSIFKTPDAFKTLMAILGTN 234
            .|             .|:    |....:.|.||.   |||               :.:..|..|.
Human   471 SQLKAAVTPELCPDVTIW----GVAMLRHMLQLQ---CNA---------------QAMTTIQHTG 513

  Fly   235 SQGIATSVLSQWVAKVSDLPLTDSEKEQLDTVIDGLYAKVGEFAGEFLNNEGSGLYLLQSKINHS 299
            .:|   |:            :|||.:.:|.|                      |::.:.|.:|||
Human   514 PKG---SI------------VTDSRQVRLAT----------------------GIFPVISLLNHS 541

  Fly   300 CVPNACSTFPYSNDIVVLKALAPIQQGEEICISYLDECMLERSR---HSRHKVLRENYVFICQCP 361
            |.||...:|  .:.:..::|...|::|:||...|..    .:||   ..|.:.||..|.|.|.||
Human   542 CSPNTSVSF--ISTVATIRASQRIRKGQEILHCYGP----HKSRMGVAERQQKLRSQYFFDCACP 600

  Fly   362 KCRAQA 367
            .|:.:|
Human   601 ACQTEA 606

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.