DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SNF4Agamma and prkag3b

DIOPT Version :9

Sequence 1:	NP_001163671.1	Gene:	SNF4Agamma / 42515	FlyBaseID:	FBgn0264357	Length:	1400	Species:	Drosophila melanogaster
Sequence 2:	NP_001035456.2	Gene:	prkag3b / 678619	ZFINID:	ZDB-GENE-060421-6938	Length:	342	Species:	Danio rerio

Alignment Length:	323	Identity:	182/323 - (56%)
Similarity:	241/323 - (74%)	Gaps:	6/323 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   906 PFLEKVNLS-----DLEEDDSQIFVKFFRFHKCYDLIPTSAKLVVFDTQLLVKKAFYALVYNGVR 965
            ||:|...|:     .|::.|:.::.|||..|.|||.||||:|||||||.|.|||||:|||.||||
Zfish    14 PFMEDEGLTMKRTGPLQDPDADVYAKFFMSHCCYDAIPTSSKLVVFDTTLQVKKAFFALVANGVR 78

  Fly   966 AAPLWDSEKQQFVGMLTITDFIKILQMYYKSPNASMEQLEEHKLDTWR-SVLHNQVMPLVSIGPD 1029
            ||||||.:.|.|||||||||||.||..|||||...:.:|||||::||| :.|...|..|:||.||
Zfish    79 AAPLWDDKLQCFVGMLTITDFINILHRYYKSPLVQIYELEEHKIETWRETYLQYSVTSLISIAPD 143

  Fly  1030 ASLYDAIKILIHSRIHRLPVIDPATGNVLYILTHKRILRFLFLYINELPKPAYMQKSLRELKIGT 1094
            :||::||..|:.::|||||||||.|||||:||||||||:||.::.:.:|||.::||.:.|::|||
Zfish   144 SSLFEAIYSLLKNKIHRLPVIDPETGNVLHILTHKRILKFLHIFGSMIPKPRFLQKRIEEVEIGT 208

  Fly  1095 YNNIETADETTSIITALKKFVERRVSALPLVDSDGRLVDIYAKFDVINLAAEKTYNDLDVSLRKA 1159
            :.:|.|..||.::..||..||||||||||:|:..|::|.:|::||||||||:||||.|::::.:|
Zfish   209 FKSIATVKETETVYDALTIFVERRVSALPVVNEQGKVVALYSRFDVINLAAQKTYNHLNMTMAEA 273

  Fly  1160 NEHRNEWFEGVQKCNLDESLYTIMERIVRAEVHRLVVVDENRKVIGIISLSDILLYLVLRPSG 1222
            .:.|....|||.||...|:|.|:::||..|||||||:||....|.||:||||:|..|||.|:|
Zfish   274 IQGRWCCIEGVLKCYPHETLETVIDRIAEAEVHRLVLVDTEDVVRGIVSLSDLLQALVLTPAG 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNF4Agamma	NP_001163671.1	CBS_pair_5	941..1069	CDD:239990	87/128 (68%)
		CBS	952..1067	CDD:223591	77/115 (67%)
		CBS	1023..1141	CDD:223591	65/117 (56%)
		CBS_pair_28	1097..1215	CDD:240012	62/117 (53%)
		CBS	1097..1213	CDD:223591	61/115 (53%)
prkag3b	NP_001035456.2	CBS_pair_5	54..183	CDD:239990	87/128 (68%)
		CBS	135..255	CDD:223591	65/119 (55%)
		CBS_pair_28	210..329	CDD:240012	62/118 (53%)
		CBS	210..327	CDD:223591	61/116 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	64	1.000	Domainoid score	I10121
eggNOG	1	0.900	-	-		E1_COG0517
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000896
OrthoInspector	1	1.000	-	-		otm25595
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13780
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4230
SonicParanoid	1	1.000	-	-		X716
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.900