DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SNF4Agamma and cbs2

DIOPT Version :9

Sequence 1:	NP_001163671.1	Gene:	SNF4Agamma / 42515	FlyBaseID:	FBgn0264357	Length:	1400	Species:	Drosophila melanogaster
Sequence 2:	NP_001342925.1	Gene:	cbs2 / 5802929	PomBaseID:	SPAC1556.08c	Length:	334	Species:	Schizosaccharomyces pombe

Alignment Length:	318	Identity:	113/318 - (35%)
Similarity:	187/318 - (58%)	Gaps:	17/318 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   913 LSDLEEDDSQIFVK---FFRFHKCYDLIPTSAKLVVFDTQLLVKKAFYALVYNGVRAAPLWDSEK 974
            ::|::|.......:   |.|....||::|||.:|:|||..|.||.:...|..|.:.:|||||||.
pombe     1 MTDVQETQKGALKEIQAFIRSRTSYDVLPTSFRLIVFDVTLFVKTSLSLLTLNNIVSAPLWDSEA 65

  Fly   975 QQFVGMLTITDFIKILQMYYKS---PNASMEQLEEHKLDTWRSVLH--NQVMP-LVSIGPDASLY 1033
            .:|.|:||:.||:.:::.||:|   |.| :.::::.:|...|.|..  ..:.| .:.:.|..||.
pombe    66 NKFAGLLTMADFVNVIKYYYQSSSFPEA-IAEIDKFRLLGLREVERKIGAIPPETIYVHPMHSLM 129

  Fly  1034 DAIKILIHSRIHRLPVI--DPATGN--VLYILTHKRILRFLFLYINELPKPAYMQKSLRELKIGT 1094
            ||...:..||..|:|:|  |..||:  ::.:||..|||:|:.:...|   .|.::..|.::.|||
pombe   130 DACLAMSKSRARRIPLIDVDGETGSEMIVSVLTQYRILKFISMNCKE---TAMLRVPLNQMTIGT 191

  Fly  1095 YNNIETADETTSIITALKKFVERRVSALPLVDSDGRLVDIYAKFDVINLAAEKTYNDLDVSLRKA 1159
            ::|:.||...|.:...:|...|:.:||:|:|:|:|.|:::|...||::|..:..|::||:|:.:|
pombe   192 WSNLATASMETKVYDVIKMLAEKNISAVPIVNSEGTLLNVYESVDVMHLIQDGDYSNLDLSVGEA 256

  Fly  1160 NEHRNEWFEGVQKCNLDESLYTIMERIVRAEVHRLVVVDENRKVIGIISLSDILLYLV 1217
            ...|...|:||..|...:.|..|.:.|..:.||||.|||||.|:.||:||:|||.|::
pombe   257 LLKRPANFDGVHTCRATDRLDGIFDAIKHSRVHRLFVVDENLKLEGILSLADILNYII 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNF4Agamma	NP_001163671.1	CBS_pair_5	941..1069	CDD:239990	49/137 (36%)
		CBS	952..1067	CDD:223591	42/124 (34%)
		CBS	1023..1141	CDD:223591	40/121 (33%)
		CBS_pair_28	1097..1215	CDD:240012	47/117 (40%)
		CBS	1097..1213	CDD:223591	45/115 (39%)
cbs2	NP_001342925.1	CBS_pair_5	32..165	CDD:239990	46/133 (35%)
cbs2	NP_001342925.1	CBS_pair_28	193..312	CDD:240012	47/118 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	45	1.000	Domainoid score	I3570
eggNOG	1	0.900	-	-		E1_COG0517
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H135205
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000896
OrthoInspector	1	1.000	-	-		oto100573
orthoMCL	1	0.900	-	-		OOG6_101734
Panther	1	1.100	-	-	LDO	PTHR13780
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4230
SonicParanoid	1	1.000	-	-		X716
TreeFam	1	0.960	-	-
	11	10.800