DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SNF4Agamma and PRKAG3

DIOPT Version :9

Sequence 1:	NP_001163671.1	Gene:	SNF4Agamma / 42515	FlyBaseID:	FBgn0264357	Length:	1400	Species:	Drosophila melanogaster
Sequence 2:	NP_059127.2	Gene:	PRKAG3 / 53632	HGNCID:	9387	Length:	489	Species:	Homo sapiens

Alignment Length:	484	Identity:	198/484 - (40%)
Similarity:	290/484 - (59%)	Gaps:	55/484 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 QNFSHRQHPAVTITS--------ADGTQSTAKSKYKDGSAHPHQGSDAQYYHTVTAVRP---NSS 815
            :|.|....||||.:|        |...:.|.:...::|.. |.||...:       .||   ::.
Human    32 ENSSSWPSPAVTSSSERIRGKRRAKALRWTRQKSVEEGEP-PGQGEGPR-------SRPAAESTG 88

  Fly   816 QRSPMTKVMDLFRHRSSSV----------VSEADKRKARAAAHQQQLAVQSAHMRRASADLEKRR 870
            ..:...|...|.:...:.|          .|:.....|.::....:||.:.........:||
Human    89 LEATFPKTTPLAQADPAGVGTPPTGWDCLPSDCTASAAGSSTDDVELATEFPATEAWECELE--- 150

  Fly   871 ASVGAAGRGLRGDGTLDPHHAAILFRDSRGLPVADPFLEKVNLSD-LEEDDSQIFVKFFRFHKCY 934
                         |.|:...|..|      .|.| || .|:...| |.:..:||:::|.:.|.||
Human   151 -------------GLLEERPALCL------SPQA-PF-PKLGWDDELRKPGAQIYMRFMQEHTCY 194

  Fly   935 DLIPTSAKLVVFDTQLLVKKAFYALVYNGVRAAPLWDSEKQQFVGMLTITDFIKILQMYYKSPNA 999
            |.:.||:|||:|||.|.:||||:|||.|||||||||||:||.|||||||||||.:|..||:||..
Human   195 DAMATSSKLVIFDTMLEIKKAFFALVANGVRAAPLWDSKKQSFVGMLTITDFILVLHRYYRSPLV 259

  Fly  1000 SMEQLEEHKLDTWRSV-LHNQVMPLVSIGPDASLYDAIKILIHSRIHRLPVIDPATGNVLYILTH 1063
            .:.::|:||::|||.: |.....|||||.|:.||::|:..||.:|||||||:||.:||||:||||
Human   260 QIYEIEQHKIETWREIYLQGCFKPLVSISPNDSLFEAVYTLIKNRIHRLPVLDPVSGNVLHILTH 324

  Fly  1064 KRILRFLFLYINELPKPAYMQKSLRELKIGTYNNIETADETTSIITALKKFVERRVSALPLVDSD 1128
            ||:|:||.::.:.||:|:::.:::::|.|||:.::....||..|:|||..||:|||||||:|:..
Human   325 KRLLKFLHIFGSLLPRPSFLYRTIQDLGIGTFRDLAVVLETAPILTALDIFVDRRVSALPVVNEC 389

  Fly  1129 GRLVDIYAKFDVINLAAEKTYNDLDVSLRKANEHRNEWFEGVQKCNLDESLYTIMERIVRAEVHR 1193
            |::|.:|::||||:|||::|||.||:|:.:|...|....|||..|...|||..:::||.|.:|||
Human   390 GQVVGLYSRFDVIHLAAQQTYNHLDMSVGEALRQRTLCLEGVLSCQPHESLGEVIDRIAREQVHR 454

  Fly  1194 LVVVDENRKVIGIISLSDILLYLVLRPSG 1222
            ||:|||.:.::|::||||||..|||.|:|
Human   455 LVLVDETQHLLGVVSLSDILQALVLSPAG 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNF4Agamma	NP_001163671.1	CBS_pair_5	941..1069	CDD:239990	81/128 (63%)
		CBS	952..1067	CDD:223591	73/115 (63%)
		CBS	1023..1141	CDD:223591	60/117 (51%)
		CBS_pair_28	1097..1215	CDD:240012	59/117 (50%)
		CBS	1097..1213	CDD:223591	57/115 (50%)
PRKAG3	NP_059127.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..113		18/88 (20%)
		CBS_pair_5	201..330	CDD:239990	81/128 (63%)
		AMPK pseudosubstrate	293..314		12/20 (60%)
		CBS_pair_28	357..476	CDD:240012	59/118 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8779
eggNOG	1	0.900	-	-		E1_COG0517
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000896
OrthoInspector	1	1.000	-	-		otm40465
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13780
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X716
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.870