DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SNF4Agamma and Prkag2

DIOPT Version :9

Sequence 1:	NP_001163671.1	Gene:	SNF4Agamma / 42515	FlyBaseID:	FBgn0264357	Length:	1400	Species:	Drosophila melanogaster
Sequence 2:	XP_017448218.1	Gene:	Prkag2 / 373545	RGDID:	727782	Length:	598	Species:	Rattus norvegicus

Alignment Length:	627	Identity:	248/627 - (39%)
Similarity:	333/627 - (53%)	Gaps:	108/627 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   647 VGSRSGSLERRRSGEDSPVLNQST--VHGIASPNRRPTIFDVFRPRAKSDAKRQKEKHLLDPSSA 709
            |.|..||     ||:.:|.|.:.:  ||       .|.:.....|....|.:..::.......|.
  Rat    14 VSSPGGS-----SGKKNPSLKRRSLRVH-------IPDLSSFAMPLLDGDVENSEKHSSRKVDSP 66

  Fly   710 DSSATSSTYSVSGGTGPATSSAAGGAGGAAAAAGQGAAGGAGGLMNSMKVAMQNFSHRQHP--AV 772
            .||.:.|....|.|..|..||..........:.|            |.|.... ||:::.|  :.
  Rat    67 FSSGSPSRGLFSRGPQPRPSSPVSAPVRPKMSPG------------SPKTVFP-FSYQESPPRSP 118

  Fly   773 TITSADGTQSTAKSKYKDGSAHPHQGSDAQYYHTVTAVRPNSSQRSPMTKVMDLFRHRSSSVVSE 837
            ...|..|   ..:|..|:.|                   |||:..:....:....|.|.:|.||.
  Rat   119 RRMSFSG---IFRSSSKESS-------------------PNSNPSTSPGGIRFFSRSRKTSSVSS 161

  Fly   838 ADKRKARAAAHQQQLAVQSAHMRRASADLEKR-RASVGAAGRGLRGDGTLDPHHAAILFRDSRGL 901
            :.....: ...|....::|  .::....||.| .||......|.|         ..:.|:....|
  Rat   162 SPSTPTQ-VTKQHPFPLES--YKQEPERLESRIYASSSPPDTGQR---------FCLAFQSPVRL 214

  Fly   902 PVADP---------------------FLEKVNLSDLEED-DSQIFVKFFRFHKCYDLIPTSAKLV 944
            |:|.|                     .|||:...:..|| :|.::::|.|.|||||::|||:|||
  Rat   215 PLASPTHHAPLRTAALAAAPGPAEAGMLEKLEFQEEAEDSESGVYMRFMRSHKCYDIVPTSSKLV 279

  Fly   945 VFDTQLLVKKAFYALVYNGVRAAPLWDSEKQQFVGMLTITDFIKILQMYYKSPNASMEQLEEHKL 1009
            ||||.|.|||||:|||.|||||||||:|:||.|||||||||||.||..|||||...:.:|||||:
  Rat   280 VFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFINILHRYYKSPMVQIYELEEHKI 344

  Fly  1010 DTWRSV-LHNQVMPLVSIGPDASLYDAIKILIHSRIHRLPVIDPATGNVLYILTHKRILRFLFLY 1073
            :|||.: |.....|||:|.|||||:||:..||.::|||||||||.:||.||||||||||:||.|:
  Rat   345 ETWRELYLQETFKPLVNISPDASLFDAVYSLIKNKIHRLPVIDPISGNALYILTHKRILKFLQLF 409

  Fly  1074 INELPKPAYMQKSLRELKIGTYNNIETADETTSIITALKKFVERRVSALPLVDSDGRLVDIYAKF 1138
            ::::||||:|:::|.||.||||:||......|.||.||..|||||:||||:||..|::||||:||
  Rat   410 MSDMPKPAFMKQNLDELGIGTYHNIAFIHPNTPIIKALNIFVERRISALPVVDESGKVVDIYSKF 474

  Fly  1139 DVINLAAEKTYNDLDVSLRKANEHRNEWFEGVQKCNLDESLYTIMERIVRAEVH--------RLV 1195
            ||||||||||||:||:::.:|.:||:::||||.||:..|:|.||::|||||||.        ..|
  Rat   475 DVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCSKLETLETIVDRIVRAEVRDRSPPHIFPRV 539

  Fly  1196 VVDENRKVIGIISLSDILLYLVLRPS----GEGV--GGSESS 1231
            .....::|:|       .|...||||    ..||  |||..|
  Rat   540 CWAHTQQVVG-------RLLGRLRPSPGRQATGVCRGGSRRS 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNF4Agamma	NP_001163671.1	CBS_pair_5	941..1069	CDD:239990	89/128 (70%)
		CBS	952..1067	CDD:223591	79/115 (69%)
		CBS	1023..1141	CDD:223591	74/117 (63%)
		CBS_pair_28	1097..1215	CDD:240012	62/125 (50%)
		CBS	1097..1213	CDD:223591	62/123 (50%)
Prkag2	XP_017448218.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	78	1.000	Domainoid score	I8552
eggNOG	1	0.900	-	-		E1_COG0517
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000896
OrthoInspector	1	1.000	-	-		otm44607
orthoMCL	1	0.900	-	-		OOG6_101734
Panther	1	1.100	-	-	O	PTHR13780
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X716
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.810