DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SNF4Agamma and aakg-1

DIOPT Version :9

Sequence 1:	NP_001163671.1	Gene:	SNF4Agamma / 42515	FlyBaseID:	FBgn0264357	Length:	1400	Species:	Drosophila melanogaster
Sequence 2:	NP_001368643.1	Gene:	aakg-1 / 3565679	WormBaseID:	WBGene00013732	Length:	801	Species:	Caenorhabditis elegans

Alignment Length:	870	Identity:	294/870 - (33%)
Similarity:	420/870 - (48%)	Gaps:	168/870 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   525 LRSESSASTTSP-SRQLTNSGSVSVSVSDDEQDGSLGGAGRMPGSRPSSAPAEPNAKAAKKAYKK 588
            ||..|:.|.||| :|.:.:..||.|...:.:|..:.|      ..||.:..|.|.....
Worm     4 LRQSSATSPTSPVARNVYSRASVDVETGEIQQQQNSG------HKRPYTPGASPREILC------ 56

  Fly   589 MEKEQRRQEKEQSRREKEARKLERETARRNEREAAKLEKINRHSEKISRSTERMAMAGV------ 647
             .::..||....|:......:. .:..||..|:|:    :|..||.:  ..|.:....|
Worm    57 -AQQSLRQLPSPSQTSPHGSRF-MDGYRRRMRQAS----LNLPSETL--LDEDLGFPPVCSPPPE 113

  Fly   648 ---GSRSGSLERRRS-GEDSPVLNQSTVHGIASPNRRPTIFDVFRPRAKSDAKRQKEKHLLD--- 705
               ||..|:..|.|| .|..|.|...:.|.:.:..     ..||.|.:.|.:. ....|||.
Worm   114 VFCGSIVGNQMRNRSNSEAQPGLRMRSSHSLGNGG-----LLVFFPTSPSSSS-NNSGHLLQHRR 172

  Fly   706 PSSADSSATSS-TYSVSGGT-------------------------GPATSSAAGGA--------- 735
            .|..|.:|..: .:|.:..|                         .|....||||:
Worm   173 ESHTDETAEEAIIWSTNNDTSDEMMDETSCCMVADDISMKDVEMPSPIIGGAAGGSKSLKRPPDL 237

  Fly   736 -GGAAAAAGQGAAGGA-GGLMNSMKVAMQNFSHRQHPAVTITSADGTQSTAKSKYKDGSAHPHQG 798
             |...:.:...::||| .|:..|......::|.|..|....|.               .|:..|.
Worm   238 NGSNNSGSSSSSSGGANSGVQQSSVHPSNSYSPRSRPLFVDTQ---------------MANHLQD 287

  Fly   799 SDAQYYHTVTAVRPNSSQRSPMTKVMDLFRHR--------SSSVVSEADKRKARAAAH------- 848
            |             |..:|||:::|:|..|.|        |||.:.......|||:|.
Worm   288 S-------------NMKRRSPVSQVVDFVRGRNRTYSLQLSSSPMCSPQSVAARASASCDGCNGP 339

  Fly   849 --QQQLAVQSAHMRRASADLEKRRASVGAAGRGLRGDGTLD---P--HHAAILFR--------DS 898
              ..|....|...||.:......|||..|.|.....|..||   |  :|.|:|.:        ||
Worm   340 PPPPQPIGMSPSGRRQTISGRVHRASFTAGGTLKSFDSGLDLSSPTINHTALLIKEASLFSSFDS 404

  Fly   899 RGLPVADPFLEKVNLSDLEEDDSQIFVKFFRFHKCYDLIPTSAKLVVFDTQLLVKKAFYALVYNG 963
            ..:..|.|   .:|....:..|: ::..|.:.||||||||||:|||||||.|.|:||||||||||
Worm   405 MSIGTAVP---DINAIFFDNHDA-VYSLFMKAHKCYDLIPTSSKLVVFDTHLPVRKAFYALVYNG 465

  Fly   964 VRAAPLWDSEKQQFVGMLTITDFIKILQMYY-KSPNAS-MEQLEEHKLDTWRS--VLHNQVMPLV 1024
            ||||||||::.|:|.||||||||||||..:| |..|:. :..||:.::..||.  .|...:.|.|
Worm   466 VRAAPLWDTDNQRFTGMLTITDFIKILCKHYDKGDNSERIRALEDQQISHWRDQFELDGTLRPFV 530

  Fly  1025 SIGPDASLYDAIKILIHSRIHRLPVIDPATGNVLYILTHKRILRFLFLYINELPKPAYMQKSLRE 1089
            .|.|:.||:.|:::|..|::|||||:|..|||:.||||||||::||.||:.:||:|::|..:.||
Worm   531 YIDPNESLHRAVELLCESKVHRLPVLDRKTGNITYILTHKRIMKFLSLYMRDLPRPSFMSCTPRE 595

  Fly  1090 LKIGTYNNIETADETTSIITALKKFVERRVSALPLVDSDGRLVDIYAKFDVINLAAEKTYNDLDV 1154
            |.||.:.:|......|.|..||:.|::.|||||||:|.:||:||||||||||:||||.:|:.||.
Worm   596 LGIGAWGDILCCHVDTPIHDALELFLKNRVSALPLIDENGRVVDIYAKFDVISLAAESSYDKLDC 660

  Fly  1155 SLRKANEHRNEWFEGVQKCNLDESLYTIMERIVRAEVHRLVVVDENRKVIGIISLSDILLYLVLR 1219
            ::::|.:||:|||||||.|...:||:.::|.||:||||||:|.|:::||:|::||||||..|||.
Worm   661 TVQEALQHRSEWFEGVQTCLETDSLFQVLEAIVKAEVHRLIVTDQDKKVVGVVSLSDILKNLVLD 725

  Fly  1220 P----------SGEGVGGSESSLRASDPVLLRKVAEVEIPATAAAATTTTPPRSPSAGSGNRSLI 1274
            |          |.:..||...:..||.            .:|..|:::.:||.|...|.   .:.
Worm   726 PCQKPPPPPPQSQQAGGGGPPTRNASG------------TSTGGASSSDSPPHSIPEGI---EVE 775

  Fly  1275 EDIPEEETAPARSDDADSDNNKSAS 1299
            :|..::|.||..|.|..:....||:
Worm   776 DDDDDDEEAPPPSIDCSTPGPSSAA 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNF4Agamma	NP_001163671.1	CBS_pair_5	941..1069	CDD:239990	75/131 (57%)
		CBS	952..1067	CDD:223591	66/118 (56%)
		CBS	1023..1141	CDD:223591	62/117 (53%)
		CBS_pair_28	1097..1215	CDD:240012	66/117 (56%)
		CBS	1097..1213	CDD:223591	64/115 (56%)
aakg-1	NP_001368643.1	CBS_euAMPK_gamma-like_repeat1	434..574	CDD:341388	84/139 (60%)
aakg-1	NP_001368643.1	CBS_euAMPK_gamma-like_repeat2	601..723	CDD:341399	66/121 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	65	1.000	Domainoid score	I6627
eggNOG	1	0.900	-	-		E1_COG0517
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	364	1.000	Inparanoid score	I1267
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000896
OrthoInspector	1	1.000	-	-		oto19654
orthoMCL	1	0.900	-	-		OOG6_101734
Panther	1	1.100	-	-	LDO	PTHR13780
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4230
SonicParanoid	1	1.000	-	-		X716
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.850