DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SNF4Agamma and Clcn6

DIOPT Version :9

Sequence 1:	NP_001163671.1	Gene:	SNF4Agamma / 42515	FlyBaseID:	FBgn0264357	Length:	1400	Species:	Drosophila melanogaster
Sequence 2:	NP_036059.1	Gene:	Clcn6 / 26372	MGIID:	1347049	Length:	870	Species:	Mus musculus

Alignment Length:	319	Identity:	65/319 - (20%)
Similarity:	103/319 - (32%)	Gaps:	117/319 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   937 IPTSAKLVVFD-TQLLVKKAFYALVYNGVRAAPLWDSEKQQFVGMLTITDFIKILQMYYKSPNAS 1000
            :|....|:|.. |..|..|..|. |:.|:|..||.:.|....:..|..:|.:: ..:.|..|
Mouse   556 LPIMVTLMVAKWTGDLFNKGIYD-VHIGLRGVPLLEWETDVEMDKLRASDIME-PNLTYVYP--- 615

  Fly  1001 MEQLEEHKLDTWRSVLHNQVMPLVSIGPDASLYDAIKILIHSRIHRLPVIDPATGNVLYILTHKR 1065
                            |.::..||||         ::..:|   |..||:....||      .|.
Mouse   616 ----------------HTRIQSLVSI---------LRTTVH---HAFPVVTENRGN------EKE 646

  Fly  1066 ILRFLFLYINEL--PKPAYMQKSLRELKIG----TYNNIE---------TADETTSIITALKKFV 1115
            .::...|..|.:  .|.:.:.::..:.|.|    :|.:.|         .::|.......|::.:
Mouse   647 FMKGNQLISNNIKFKKSSILTRAGEQRKRGQSMKSYPSSELRNVCDEHVASEEPAEKEDLLQQML 711

  Fly  1116 ERRVSALPLVDSDGRLVDIYAKFDVINLAAEKTYNDLDVSLRKANEHRNEWFEGVQKCNLDESLY 1180
            |||.:..|                  ||     |.|...|        .:|
Mouse   712 ERRYTPYP------------------NL-----YPDQSPS--------EDW-------------- 731

  Fly  1181 TIMERIVRAEVHRLVVVDENRKVIGIISLSDILLYLVLRPSGEGVGGSESSLRASDPVL 1239
            |:.||......|            |::..|.::..||     .||..|||...||.|.|
Mouse   732 TMEERFRPLTFH------------GLVLRSQLVTLLV-----RGVCYSESQSSASQPRL 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNF4Agamma	NP_001163671.1	CBS_pair_5	941..1069	CDD:239990	28/128 (22%)
		CBS	952..1067	CDD:223591	24/114 (21%)
		CBS	1023..1141	CDD:223591	24/132 (18%)
		CBS_pair_28	1097..1215	CDD:240012	19/126 (15%)
		CBS	1097..1213	CDD:223591	19/124 (15%)
Clcn6	NP_036059.1	ClC_6_like	49..589	CDD:239657	11/33 (33%)
		Voltage_CLC	140..571	CDD:279048	4/14 (29%)
		Selectivity filter part_1. /evidence=ECO:0000250	156..160
		Selectivity filter part_2. /evidence=ECO:0000250	198..202
		Selectivity filter part_3. /evidence=ECO:0000250	488..492
		CBS	609..656	CDD:214522	15/83 (18%)
		CBS_pair_EriC_assoc_euk_bac	<801..854	CDD:239964
		CBS	804..>854	CDD:223591
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910