DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SNF4Agamma and mug70

DIOPT Version :9

Sequence 1:	NP_001163671.1	Gene:	SNF4Agamma / 42515	FlyBaseID:	FBgn0264357	Length:	1400	Species:	Drosophila melanogaster
Sequence 2:	NP_594030.1	Gene:	mug70 / 2541689	PomBaseID:	SPAC24C9.05c	Length:	730	Species:	Schizosaccharomyces pombe

Alignment Length:	823	Identity:	153/823 - (18%)
Similarity:	285/823 - (34%)	Gaps:	286/823 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   616 RRNEREAAKLEKINRHSEKISRSTERMAMAGVGSRSGSLER-----RRSGE----DSPVLNQS-T 670
            |:.:|:.|..:||               ::.:|.:||:.|.     ||:||    ||..|:.: |
pombe    26 RQYQRDEALRKKI---------------ISELGKKSGNFESPVRKIRRNGEPGTVDSAALDPALT 75

  Fly   671 VHGIASPNRRPTIFDVFRPRAKSDAKRQK-------EKHLLDPSSADSSAT-------------- 714
            ||      .:..:.:..:..|   ||||.       ::.|....:|...||
pombe    76 VH------MQSLVTETAQLMA---AKRQNCVLVVDDDEQLAGIVTATDIATRCVGAGLNARQTLI 131

  Fly   715 -----SSTYSVSGGTG----------------PATSSAAGGAGGAAAAAGQGAAGGAGGLMN--- 755
                 :|...::..|.                |..|.  ||..|:|     |..|...|::|
pombe   132 ADIMSTSPLCITSDTRFDDALLLMIEHKFRHLPVVSD--GGPDGSA-----GDEGDVIGIINMRA 189

  Fly   756 SMKVAMQNFSHRQHPAVTITSA-DGTQSTAKSKYKDGSAHPHQGSD---AQYYHTVTAVRPNSSQ 816
            .::..:...:.:|..|..:..| :|.|...::|...|:.:....|.   |::...|.:::..:|.
pombe   190 CLREPLNRIARQQEAAQKLVEALEGAQEEIENKSVSGNTNSSSVSGNHAAEFLEYVESLKKKASG 254

  Fly   817 RSPMTKV---MDLFRHRSSSVVSEADKRKARAAAHQQQL-------AVQSAH---MRRASADLEK 868
            ...|:.:   .:.|...:.:.|:||.:..||:......:       .|.:||   :|..:|.|:.
pombe   255 LEIMSLIDSSEEPFLVGTRTTVAEATESMARSGVSAVLVMDNGAVSGVFTAHDVVLRVLAAGLDP 319

  Fly   869 RRASVGAAGRGLRGDGTLDPHHAAILFRDSRGLPVADPFLEKV------NLSDLEEDDSQI-FVK 926
            .|:||      :|   .:.||....|    ..|.|:.. ||::      ||..::|.|:.| .:.
pombe   320 YRSSV------IR---VMTPHPDCAL----ASLRVSTA-LERMIEGKFSNLPVVDESDAIIGMLS 370

  Fly   927 FFRFHKCYDLIPTSAKLVVFDTQLLVKKAFYALVYNGVRAAPLWDSEKQQFVGMLTITDFIKILQ 991
            .|......:..|...: .|||         .|....|:..:..::.::||.:|     :..::::
pombe   371 LFHLATAIEQTPEEEE-EVFD---------QAENDAGIEPSNGFEDQQQQLLG-----NSNEVVE 420

  Fly   992 MYYKSP------------------NASMEQLEEHKLDTWRSV-LHNQVMPLVSIG---------- 1027
            .|..:|                  ..|..||.:..:..|::. |.:...|...:|
pombe   421 NYDVNPPLPLNPLPSNTQQSESTYEYSARQLPKPPVQAWQNENLSSNNKPQEYVGVENDYNFSNN 485

  Fly  1028 PDASLYDAIKILIHSRIHRLPVIDPATGN-----VLYILTHKRILRFLFLYINELPK----PAYM 1083
            |..::.:.   ..|..:.:.|:..|..|:     ..|:..:....:....|:..||:    |:::
pombe   486 PPTAMSEQ---SFHPSVSQKPMDTPENGSNSFAASPYLQPYNSASQLAPSYVGSLPQYHGNPSFV 547

  Fly  1084 QKSLRELKIGTYNNIETADETTSI----------ITALKKFVERRVSALPLVDSDGRLVDIYAKF 1138
            :::|::|       ::..|..:.|          .|...:.:..||..|              :.
pombe   548 EQALQDL-------VQPTDSASQIFPLNPQSPSQFTIKYRSIAGRVHRL--------------RL 591

  Fly  1139 DVINLAAEKTYNDLDVSLRKANEHRNEWFEGVQKCNLDESLYTIMERIVRAEVHRLVVVDENRKV 1203
            |.||..::         ||.|.|.|.:           |.|.|            |..:|:...|
pombe   592 DGINSVSD---------LRTAVEEREK-----------EQLVT------------LTYIDDEGDV 624

  Fly  1204 IGIISLSDILLYLVL-------RPSGEGVGGSESSLRASDPVLLRKVAEVEIPATAAAATTTTPP 1261
            :.::|.||:...::|       |....||....:.|.:|.|                      |.
pombe   625 VELVSDSDLREAILLARRRGLPRLEVRGVAAFTNHLESSHP----------------------PI 667

  Fly  1262 RSPSAGSGNRSLIE--------DIPEEETAPARSDDADSDNNK 1296
            .:..:..|:.|::|        || .:.||     .||..|:|
pombe   668 STVDSSIGSASVVEKGVANSIVDI-HQPTA-----KADKGNSK 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNF4Agamma	NP_001163671.1	CBS_pair_5	941..1069	CDD:239990	23/161 (14%)
		CBS	952..1067	CDD:223591	20/148 (14%)
		CBS	1023..1141	CDD:223591	20/146 (14%)
		CBS_pair_28	1097..1215	CDD:240012	23/127 (18%)
		CBS	1097..1213	CDD:223591	23/125 (18%)
mug70	NP_594030.1	CBS_pair	12..115	CDD:301603	26/112 (23%)
		CBS_pair_CAP-ED_DUF294_PBI_assoc	71..182	CDD:239960	22/126 (17%)
		CBS	75..188	CDD:223591	24/128 (19%)
		CBS_pair_CAP-ED_DUF294_PBI_assoc	265..377	CDD:239960	29/125 (23%)
		CBS	266..374	CDD:223591	29/121 (24%)
		PB1_MUG70	575..655	CDD:99730	25/125 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0517
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810