DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SNF4Agamma and aakg-3

DIOPT Version :9

Sequence 1:	NP_001163671.1	Gene:	SNF4Agamma / 42515	FlyBaseID:	FBgn0264357	Length:	1400	Species:	Drosophila melanogaster
Sequence 2:	NP_508509.3	Gene:	aakg-3 / 189836	WormBaseID:	WBGene00021527	Length:	425	Species:	Caenorhabditis elegans

Alignment Length:	409	Identity:	121/409 - (29%)
Similarity:	216/409 - (52%)	Gaps:	55/409 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   855 QSAHMRRASADLE------KRRASVGAAGRGLRGDGTLDPHHAAILFRDSRGLPVADPFLEKVNL 913
            :|..:.:|..||:      ||:|.|... ..::.||.....||.:.:.:       |...::...
Worm    17 ESPSIPKAFFDLQHHFIFSKRKAPVDGI-EAIQRDGASISEHAVVKYAN-------DERPDEKEK 73

  Fly   914 SDLE-----------EDDSQIFVKFFRFHKCYDLIPTSAKLVVFDTQLLVKKAFYALVYNGVRAA 967
            .|||           ::...::....:..:||:.:..:.||:||...:.|:|||..|:||.:|..
Worm    74 QDLENMFKTVLRIGVQNSDIVYTHLLQLSQCYEAMARNNKLIVFTNDISVRKAFNGLIYNCMRTG 138

  Fly   968 PLWDSEKQQFVGMLTITDFIKILQMYYKSPNASMEQLEEHK------------------LDTWRS 1014
            .:.||:..:..|:|::||||.:|.|.:|    ..|.|:|.|                  :..|:.
Worm   139 LVADSQTLEITGVLSVTDFIMVLMMLWK----YRENLDELKGTPLSHEDFRQMDIAYMPISRWKG 199

  Fly  1015 VLH--NQVMPLVSIGPDASLYDAIKILIHSRIHRLPVIDPATGNVLYILTHKRILRFLFLYINEL 1077
            .|.  .|:.|.::||...|::.|:::|...|||||||:|..||:..|||||:|||.:::.:...|
Worm   200 CLETKGQLKPFINIGLKESIFRAVELLTKYRIHRLPVMDEKTGDCAYILTHRRILHYIWKHCALL 264

  Fly  1078 PKPAYMQKSLRELKIGTYNNIETADETTSIITALKKFVERRVSALPLVDSDG-RLVDIYAKFDVI 1141
            |||..:.:.:.:|:||::.|:..|:|.|.:|..|...::..:|.:|:|..:. :::::|.:||..
Worm   265 PKPECLSQRVVDLEIGSWKNLIFANEQTPLIECLDMLIDNNISGIPIVQKNTLKVLEVYTRFDAA 329

  Fly  1142 NLAAEKTYNDLDVSLRKANEHRNEW----FEGVQKCNLDESLYTIMERIVRAEVHRLVVVDENRK 1202
            : ||...:.||.||:.:|.:.|:..    .:||...|...:|::::|..:...|||:.:||:...
Worm   330 S-AAFSDHIDLSVSVTRAIQERDYQNGIRRDGVVTANYTTTLWSLIEIFIDKNVHRIFMVDDRTI 393

  Fly  1203 VIGIISLSDILLYLVLRPS 1221
            :.|||||||::.:|||||:
Worm   394 LKGIISLSDVIEFLVLRPT 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SNF4Agamma	NP_001163671.1	CBS_pair_5	941..1069	CDD:239990	54/147 (37%)
		CBS	952..1067	CDD:223591	48/134 (36%)
		CBS	1023..1141	CDD:223591	42/118 (36%)
		CBS_pair_28	1097..1215	CDD:240012	37/122 (30%)
		CBS	1097..1213	CDD:223591	37/120 (31%)
aakg-3	NP_508509.3	CBS_pair_5	112..256	CDD:239990	54/147 (37%)
		CBS	208..327	CDD:223591	41/118 (35%)
		CBS_pair_28	283..406	CDD:240012	37/123 (30%)
		CBS	283..404	CDD:223591	37/121 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0517
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1437
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000896
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13780
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.820