Protein Alignment Snmp1 and SCARB2

DIOPT Version :10

• Sequence 1: NP_650953.1
• Gene: Snmp1 / 42514
• FlyBaseID: FBgn0260004
• Length: 551
• Species: Drosophila melanogaster
• Sequence 2: NP_005497.1
• Gene: SCARB2 / 950
• HGNCID: 1665
• Length: 478
• Species: Homo sapiens
• Alignment Length: 457
• Identity: 116/457 - (25%)
• Similarity: 213/457 - (46%)
• Gaps: 48/457 - (10%)

  Fly    26 IFPKILKFMISKQVTLKPGSDVRELWSNTPFPLHFYIYVFNVTNPDEVSEGAKPRLQEVGPFVFD 90
            :|.|.:...|.|::.|:.|::..:.|...|.|::...|.||||||:|:..|..||::||||:.:.
Human    28 VFQKAVDQSIEKKIVLRNGTEAFDSWEKPPLPVYTQFYFFNVTNPEEILRGETPRVEEVGPYTYR 92

  Fly    91 EWKDKYDLEDDVVEDTVSFTMRNTFIFNPKESLPLTGEEEIILPHPIMLPGGISVQREKAAMM-E 154
            |.::|.:::......|:|......::|...:|:   |:.:|.|...:.:|....::..:...: |
Human    93 ELRNKANIQFGDNGTTISAVSNKAYVFERDQSV---GDPKIDLIRTLNIPVLTVIEWSQVHFLRE 154

  Fly   155 LVSKGLSIVFPDAKAFLKAKFMDLFFRGINVDCSSEEFSAKALCTVFYTGEIKQAKQVNQTHF-- 217
            ::           :|.|||....||     |..:.:|.      ...|..||.....|.:...
Human   155 II-----------EAMLKAYQQKLF-----VTHTVDEL------LWGYKDEILSLIHVFRPDISP 197

  Fly   218 LFSFMGQANHSDSGRFTVCRGVKNNKKLGKVVKFADEPEQDIWPDGECNTFVGTDSTVFAPGLKK 282
            .|....:.|.::.|.:....|..:.....|:|::..:...|.|...:||...|||...|.|.:.|
Human   198 YFGLFYEKNGTNDGDYVFLTGEDSYLNFTKIVEWNGKTSLDWWITDKCNMINGTDGDSFHPLITK 262

  Fly   283 EDGLWAFTPDLCRSLGAYYQHKSSYHGMPSMRYTLDLGDIRADEKLHC-FCEDPEDLDTCPPKGT 346
            ::.|:.|..|.|||:...:....|..|:|:.||.:. .:|.|:...:. || .||  ..|...|.
Human   263 DEVLYVFPSDFCRSVYITFSDYESVQGLPAFRYKVP-AEILANTSDNAGFC-IPE--GNCLGSGV 323

  Fly   347 MNLAACV-GGPLMASMPHFYLGDPKLVADVDGLNPNEKDHAVYIDFELMSGTPFQAAKRLQFNLD 410
            :|::.|. |.|::.|.||||..|.:.|:.::|::||::||..::|...::|...:||||.|.|:.
Human   324 LNVSICKNGAPIIMSFPHFYQADERFVSAIEGMHPNQEDHETFVDINPLTGIILKAAKRFQINIY 388

  Fly   411 MEPVEGIEPMKNLPKLILPMFWVEEGVQLNK--------------TYTNLVKYTLFLGLKINSVL 461
            ::.::......::..::.|:.::.|.|.::|              ..||:....:.||:....|.
Human   389 VKKLDDFVETGDIRTMVFPVMYLNESVHIDKETASRLKSMINTTLIITNIPYIIMALGVFFGLVF 453

  Fly   462 RW 463
            .|
Human   454 TW 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Snmp1	NP_650953.1	CD36	11..480	CDD:460076	116/457 (25%)
SCARB2	NP_005497.1	CD36	28..457	CDD:460076	116/457 (25%)
		Important for interaction with GBA1	155..191		11/57 (19%)