DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5810 and Gp150

DIOPT Version :9

Sequence 1:	NP_650952.2	Gene:	CG5810 / 42513	FlyBaseID:	FBgn0038866	Length:	428	Species:	Drosophila melanogaster
Sequence 2:	NP_477049.2	Gene:	Gp150 / 37549	FlyBaseID:	FBgn0013272	Length:	1076	Species:	Drosophila melanogaster

Alignment Length:	490	Identity:	115/490 - (23%)
Similarity:	195/490 - (39%)	Gaps:	133/490 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NYLNYILIAVIAFATCE--SQKLEEIAIDSLDCRENTCTNL--KYPSASAVAYFSENVTKHLRKY 65
            |..:|::      |||.  ...:::...|..|.   ..||:  |||......:| :|:  .|:..
  Fly   267 NVNSYLV------ATCSRLDMGIQKFGSDITDL---VVTNVGPKYPILMGPNFF-QNL--GLKNV 319

  Fly    66 ETLVLHSSDLANLPRKIFLNLPQLVEFHVLECELQQIESVCFDGAKNLKRLNFGGNALRVLDSNT 130
            .::.:.:..|..|..:.|..|.:|...::.:..|..|....|.|.|.|:.|...||.|.|:.|..
  Fly   320 ASIKIANCTLEYLHAEAFHGLNELYAVNLTDVGLAIINPDTFVGNKKLRMLTISGNDLSVMSSIH 384

  Fly   131 FEL-ATQLEELNLSDNQLEDLPTTIFRPLKNLQKINLSNNRLITLSQHIFSQLGSLKSINVDSNQ 194
            :.| ::.:|||:.|.|.|.:|....|..|.|:..||||.|.|..|.:..|.::..|:.:::..|.
  Fly   385 YLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNS 449

  Fly   195 LVELPGELFRDQRKHLSEFSAQSNQLVRIPFNIF--------REIDHLSLSFN------------ 239
            |.|||.::          |:..:..::.:.:|.|        :::..|.||||
  Fly   450 LTELPRDI----------FNGTTLSILHLKYNTFNGDLHFGTKDLQQLDLSFNSIVQVHHSMFDK 504

  Fly   240 -PQLRRL----------------------HLSAKINELEATNCDL--ESVELDGRVIGVQLEANP 279
             |.|..|                      |:...||:|:..:..|  ::.|||    .::|..||
  Fly   505 MPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLDQISGMLFFKNSELD----VIRLNDNP 565

  Fly   280 KLHELKISQPQDLEHLYLANTNLYRLDFLS--------KASKLVDLDVTDIVNLADLPKITSAKG 336
            :|.:|    |.|....|.....:|.||..:        ||             .:.:|.:|:
  Fly   566 RLSQL----PTDGFLSYSGEFTVYYLDISNCAIGPLGHKA-------------FSTMPHLTT--- 610

  Fly   337 LERLSFTYDNLTSNHM--DMLPHLKDLNYLEISHEKGKEIFIKDLDEDFFVEEAELNCGQLAD-- 397
               |...::|:  ||:  ::...|..|..|::|:.     .|..:|:..|::..||....||.
  Fly   611 ---LKLAWNNI--NHLPREIFTGLHKLIDLDLSNN-----LITRMDDLIFMDNGELTKLSLAGNP 665

  Fly   398 ---LLEFVELP------------KDTTILEDRLVG 417
               |...:.||            :.||:|.||.:|
  Fly   666 ISRLSVRLFLPLHQLRCLDVNDCELTTLLSDRDLG 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5810	NP_650952.2	leucine-rich repeat	65..88	CDD:275380	4/22 (18%)
		LRR_8	87..147	CDD:290566	19/60 (32%)
		leucine-rich repeat	89..112	CDD:275380	5/22 (23%)
		leucine-rich repeat	113..136	CDD:275380	8/23 (35%)
		LRR_8	135..195	CDD:290566	20/59 (34%)
		LRR_4	135..175	CDD:289563	16/39 (41%)
		leucine-rich repeat	137..160	CDD:275380	9/22 (41%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		leucine-rich repeat	185..209	CDD:275380	6/23 (26%)
		leucine-rich repeat	210..231	CDD:275380	3/28 (11%)
Gp150	NP_477049.2	LRR_8	317..377	CDD:290566	14/59 (24%)
		leucine-rich repeat	343..366	CDD:275380	5/22 (23%)
		leucine-rich repeat	367..391	CDD:275380	8/23 (35%)
		LRR_RI	<374..619	CDD:238064	66/283 (23%)
		LRR_8	390..450	CDD:290566	20/59 (34%)
		leucine-rich repeat	393..415	CDD:275380	9/21 (43%)
		leucine-rich repeat	416..439	CDD:275380	8/22 (36%)
		leucine-rich repeat	440..483	CDD:275380	9/52 (17%)
		leucine-rich repeat	463..481	CDD:275380	2/17 (12%)
		LRR_8	484..542	CDD:290566	11/57 (19%)
		leucine-rich repeat	484..507	CDD:275380	5/22 (23%)
		leucine-rich repeat	508..531	CDD:275380	2/22 (9%)
		leucine-rich repeat	532..569	CDD:275380	12/40 (30%)
		leucine-rich repeat	556..583	CDD:275380	10/34 (29%)
		leucine-rich repeat	570..607	CDD:275380	9/53 (17%)
		LRR_RI	<586..745	CDD:238064	30/141 (21%)
		LRR_8	606..666	CDD:290566	17/72 (24%)
		leucine-rich repeat	608..631	CDD:275380	6/30 (20%)
		leucine-rich repeat	632..655	CDD:275380	6/27 (22%)
		leucine-rich repeat	656..674	CDD:275380	4/17 (24%)
		leucine-rich repeat	733..745	CDD:275378
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010