Protein Alignment CG5810 and LRRC70

DIOPT Version :10

• Sequence 1: NP_650952.2
• Gene: CG5810 / 42513
• FlyBaseID: FBgn0038866
• Length: 428
• Species: Drosophila melanogaster
• Sequence 2: NP_852607.3
• Gene: LRRC70 / 100130733
• HGNCID: 35155
• Length: 622
• Species: Homo sapiens
• Alignment Length: 351
• Identity: 82/351 - (23%)
• Similarity: 144/351 - (41%)
• Gaps: 58/351 - (16%)

  Fly    36 RENTCTNL-------KYPSASAVAYFSENVTKHLRKYETLVLHSSDLANLPRKIFLNLPQLVEFH 93
            |:..|.||       .:|.::...|.:.|...::.:.|...|||                ||..:
Human    42 RQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHS----------------LVALY 90

  Fly    94 VLECELQQIESVCFDGAKNLKRLNFGGNALRVLDSNTFELATQLEELNLSDNQLEDLPTTIFRPL 158
            :....:..:....|...::|..|....|.::.||...|:....|..|.|..||:..:|..:|..|
Human    91 LDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDL 155

  Fly   159 KNLQKINLSNNRLITLSQHIFSQLGSLKSINVDSNQLVELPGELFRDQRKHLSEFSA---QSNQL 220
            .::|.:||..|||..|....|..:.:|:.:::.:|.::.:....|    :||...:.   .||.|
Human   156 VSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGF----QHLENLACLYLGSNNL 216

  Fly   221 VRIP---FNIFREIDHLSLSFNP----QLRRLHLSAKINELEATNCDLESVELDGRVIGVQLEAN 278
            .::|   |.:.:.:..||||.||    |.......|.:..|...|..:.:|..||
Human   217 TKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDG---------- 271

  Fly   279 PKLHELKISQPQDLEHLYLANTNLYRL--DFLSKASKLV--DLDVTDIVNLADLPKITSAKGLER 339
                   .|...:|:||.|::.:|..|  |..|....|:  .||...|:::.:.........|:.
Human   272 -------FSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKI 329

  Fly   340 LSFTYDNLTSNHMDMLPHLKDLNYLE 365
            |:.:::|||:.|..:|..|..|.:|:
Human   330 LNLSFNNLTALHPRVLKPLSSLIHLQ 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5810	NP_650952.2	LRR	<61..353	CDD:443914	71/305 (23%)
		leucine-rich repeat	65..88	CDD:275380	4/22 (18%)
		leucine-rich repeat	89..112	CDD:275380	3/22 (14%)
		leucine-rich repeat	113..136	CDD:275380	6/22 (27%)
		leucine-rich repeat	137..160	CDD:275380	8/22 (36%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		leucine-rich repeat	185..209	CDD:275380	3/23 (13%)
		leucine-rich repeat	210..231	CDD:275380	6/26 (23%)
LRRC70	NP_852607.3	LRRNT	31..59	CDD:396168	4/16 (25%)
		LRR	49..>383	CDD:443914	79/344 (23%)
		LRR 1	61..82		3/20 (15%)
		leucine-rich repeat	65..85	CDD:275380	4/19 (21%)
		LRR 2	85..106		4/36 (11%)
		leucine-rich repeat	86..109	CDD:275380	3/22 (14%)
		LRR 3	109..130		6/20 (30%)
		leucine-rich repeat	110..133	CDD:275380	6/22 (27%)
		LRR 4	133..154		7/20 (35%)
		leucine-rich repeat	134..157	CDD:275380	8/22 (36%)
		LRR 5	157..178		8/20 (40%)
		leucine-rich repeat	158..181	CDD:275380	8/22 (36%)
		LRR 6	181..202		3/24 (13%)
		leucine-rich repeat	182..205	CDD:275380	5/26 (19%)
		LRR 7	205..226		5/20 (25%)
		leucine-rich repeat	206..229	CDD:275380	5/22 (23%)
		LRR 8	229..250		7/20 (35%)
		leucine-rich repeat	230..253	CDD:275380	7/22 (32%)
		LRR 9	253..274		5/37 (14%)
		leucine-rich repeat	254..277	CDD:275380	6/39 (15%)
		LRR 10	277..298		7/20 (35%)
		leucine-rich repeat	278..301	CDD:275380	8/22 (36%)
		LRR 11	301..322		4/20 (20%)
		leucine-rich repeat	302..326	CDD:275380	4/23 (17%)
		LRR 12	326..347		7/20 (35%)
		leucine-rich repeat	327..348	CDD:275380	7/20 (35%)