DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and RLP37

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_188952.1	Gene:	RLP37 / 821886	AraportID:	AT3G23110	Length:	835	Species:	Arabidopsis thaliana

Alignment Length:	601	Identity:	135/601 - (22%)
Similarity:	225/601 - (37%)	Gaps:	153/601 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ADADVDSGSSRIVL--VSSLE-GHCQTEGKVTSCRGFEFAGEDEKATF-DLPTEVRIAEDGTTYE 88
            |:..:.|.||...|  :..|| .||..:|::.|.     .|.....|: ||.....:.|  ....
plant    98 ANTSLKSSSSLFKLRHLRHLELSHCNLQGEIPSS-----IGNLSHLTYLDLSFNQLVGE--FPVS 155

  Fly    89 VGDEEHSRTL-IFENCTFTNFPLRLFYTLEVSELDMRGCGIRFIYWENFSIGAD-------KLVI 145
            :|:......: ::.|....|.|.......::|||.:|         :|...|.|       .|.|
plant   156 IGNLNQLEYIDLWVNALGGNIPTSFANLTKLSELHLR---------QNQFTGGDIVLSNLTSLSI 211

  Fly   146 LLLSDNHIEVLPTKTFRGAGNLEFIFLNRNKL-------------------------GKLQAGAF 185
            :.||.|:.....:.......|||..:::.|..                         |.:..|..
plant   212 VDLSSNYFNSTISADLSQLHNLERFWVSENSFFGPFPSFLLMIPSLVDICLSENQFEGPINFGNT 276

  Fly   186 DNLLKLQYLDLTENRLEALAADVFAGLKSLRHVGLAGN----QLTTIESDLFAHNPDLLSVAMQN 246
            .:..||..||::.|.|:.|.....:.|.||.|:.|:.|    |:.:..|.|.  |.|.|.:: .|
plant   277 TSSSKLTELDVSYNNLDGLIPKSISTLVSLEHLELSHNNFRGQVPSSISKLV--NLDGLYLS-HN 338

  Fly   247 NRLREVGEYAFRSRGRHHQMQYVDLSNN------PELVVLLLNINATNLTA------------RN 293
            |...:|....|:.    ..::::|||:|      |..:..|:|:::.:|:.            |:
plant   339 NFGGQVPSSIFKL----VNLEHLDLSHNDFGGRVPSSISKLVNLSSLDLSYNKFEGHVPQCIWRS 399

  Fly   294 CSLDRVNL-YGSVTNVDLSDNRVRELYFPASEALEH-LVLRNNSLVQLASLSRVPR-------LR 349
            ..||.|:| |.|..    |..|:.||   ..|:||. ..|.:|||     ...:|:       ..
plant   400 SKLDSVDLSYNSFN----SFGRILEL---GDESLERDWDLSSNSL-----QGPIPQWICNFRFFS 452

  Fly   350 HLDVADNPNLGQLPDGWR-TPHLEMLVLRN---TGQMELPLEALQGMQNLQKLDISGNNLTEIDP 410
            .||.::|...|.:|...: :....||.|||   :|.|  |...:.|.. |..||:|.|||....|
plant   453 FLDFSNNHLNGSIPQCLKNSTDFYMLNLRNNSLSGFM--PDFCMDGSM-LGSLDVSLNNLVGKLP 514

  Fly   411 SAFPTLTQLTHFYIHGNN-------WNCFSLRNIMDVLIRANGIAYTVDNYDPDFPGEYFHGIAC 468
            .:|.....:.:..:.||.       | ..||:.:..:::|:|..      |.|.:....:.|
plant   515 ESFINCEWMEYLNVRGNKIKDTFPVW-LGSLQYLTVLVLRSNTF------YGPVYKASAYLG--- 569

  Fly   469 MYRLPEKEGVDSSSSSEIS-------------ASVESSPITS----------SSDPSEVDKLRDE 510
               .|....:|.|:::.:.             :||...|:.:          .|:....|..:|.
plant   570 ---FPSMRIMDISNNNFVGSLPQDYFANWTEMSSVWQRPMLTLDYKRNIAIPGSNYMGDDNHQDS 631

  Fly   511 LKAVVQHFDSKFDLIF 526
            :..|.:..|:.|:.||
plant   632 IDLVYKGVDTDFEQIF 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	7/30 (23%)
		LRR_RI	143..407	CDD:238064	82/323 (25%)
		leucine-rich repeat	143..166	CDD:275380	5/22 (23%)
		LRR_8	166..225	CDD:290566	19/87 (22%)
		leucine-rich repeat	167..190	CDD:275380	5/47 (11%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		leucine-rich repeat	215..238	CDD:275380	8/26 (31%)
		leucine-rich repeat	239..265	CDD:275380	5/25 (20%)
		leucine-rich repeat	266..325	CDD:275380	19/77 (25%)
		LRR_8	304..357	CDD:290566	15/60 (25%)
		leucine-rich repeat	326..347	CDD:275380	6/21 (29%)
		leucine-rich repeat	348..394	CDD:275380	14/49 (29%)
		LRR_8	369..428	CDD:290566	19/61 (31%)
		LRR_4	393..433	CDD:289563	12/46 (26%)
		leucine-rich repeat	395..418	CDD:275380	9/22 (41%)
RLP37	NP_188952.1	LRRNT_2	39..82	CDD:311940
		PLN00113	66..>764	CDD:331614	135/601 (22%)
		leucine-rich repeat	114..137	CDD:275380	7/27 (26%)
		leucine-rich repeat	138..161	CDD:275380	5/24 (21%)
		leucine-rich repeat	162..185	CDD:275380	3/22 (14%)
		leucine-rich repeat	186..208	CDD:275380	7/30 (23%)
		leucine-rich repeat	209..281	CDD:275380	11/71 (15%)
		leucine-rich repeat	257..278	CDD:275380	2/20 (10%)
		leucine-rich repeat	282..305	CDD:275380	7/22 (32%)
		leucine-rich repeat	306..329	CDD:275380	7/24 (29%)
		leucine-rich repeat	330..353	CDD:275380	6/27 (22%)
		leucine-rich repeat	354..375	CDD:275380	5/20 (25%)
		leucine-rich repeat	402..420	CDD:275380	8/21 (38%)
		leucine-rich repeat	421..450	CDD:275380	9/36 (25%)
		leucine-rich repeat	451..474	CDD:275380	5/22 (23%)
		leucine-rich repeat	475..498	CDD:275380	9/24 (38%)
		leucine-rich repeat	499..520	CDD:275380	9/20 (45%)
		leucine-rich repeat	523..546	CDD:275380	5/23 (22%)
		leucine-rich repeat	547..572	CDD:275380	5/36 (14%)
		leucine-rich repeat	573..597	CDD:275380	2/23 (9%)
		leucine-rich repeat	598..649	CDD:275380	11/50 (22%)
		leucine-rich repeat	651..673	CDD:275380
		leucine-rich repeat	674..697	CDD:275380
		leucine-rich repeat	698..721	CDD:275380
		leucine-rich repeat	722..755	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000