DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and RLP33

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_187217.2	Gene:	RLP33 / 819733	AraportID:	AT3G05660	Length:	875	Species:	Arabidopsis thaliana

Alignment Length:	602	Identity:	130/602 - (21%)
Similarity:	212/602 - (35%)	Gaps:	172/602 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LAATATTDEDADADVDSGSSRIVLVSSLEGHCQTEGKVTSCRGFEFAGEDEKATFDLPTEVRIAE 82
            :...|.|.|..:.|        ::.|.|.|...:...::..:.|.|.     .|.||.......:
plant    75 ITCDAKTGEVIEID--------LMCSCLHGWFHSNSNLSMLQNFHFL-----TTLDLSYNHLSGQ 126

  Fly    83 DGTTYEVGDEEHSRTLIFENCTFTNF-PLRLFYTLEVSELDMRGCGIRFIYWENF------SIG- 139
            ..::  :|:..|..||......|:.: |..|.....::.|        .:|..||      |:|
plant   127 ISSS--IGNLSHLTTLDLSGNNFSGWIPSSLGNLFHLTSL--------HLYDNNFGGEIPSSLGN 181

  Fly   140 ADKLVILLLS-DNHIEVLPTKTFRGAGNLEFIFLNRNKL-GKLQAGAFDNLLKLQYLDLTENRLE 202
            ...|..|.|| :|.:..:|: :|.....|..:.|:.||| |.|..... ||.||..:.|:.|:..
plant   182 LSYLTFLDLSTNNFVGEIPS-SFGSLNQLSILRLDNNKLSGNLPLEVI-NLTKLSEISLSHNQFT 244

  Fly   203 ALAADVFAGLKSLRHVGLAGNQLT-TIESDLFAHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQM 266
            .........|..|.....:||... ||.|.||. .|.:..:.:.||:|.  |...|.:......:
plant   245 GTLPPNITSLSILESFSASGNNFVGTIPSSLFT-IPSITLIFLDNNQLS--GTLEFGNISSPSNL 306

  Fly   267 QYVDLSNN------PELVVLLLNINATNLTARNCSLDRV------------NLYGSVTN------ 307
            ..:.|..|      |..:..|:|:...:|:..|.. .:|            |||.|.:|
plant   307 LVLQLGGNNLRGPIPTSISRLVNLRTLDLSHFNIQ-GQVDFNIFSHLKLLGNLYLSHSNTTTTID 370

  Fly   308 -------------VDLSDNRV-----RELYFPASEALEHLVLRNNSLVQLASLSRVPR-LRHLDV 353
                         :|||.|.|     ..:..|....:..|.|....:.:...:.|..| :|.||:
plant   371 LNAVLSCFKMLISLDLSGNHVLVTNKSSVSDPPLGLIGSLNLSGCGITEFPDILRTQRQMRTLDI 435

  Fly   354 ADNPNLGQLPDGWRTPHLEMLVLRNTGQMELPLEALQGMQNLQKLDISGNNL------TEIDPSA 412
            ::|...||:| .|       |:|:                 |:.:.||.||.      |:::.:.
plant   436 SNNKIKGQVP-SW-------LLLQ-----------------LEYMHISNNNFIGFERSTKLEKTV 475

  Fly   413 FPTLTQLTHFYIHGNNWN-------CFSLRNIMDVLIRANGIAYTVDNYDPDFPGEYFHGIACMY 470
            .|. ..:.||:...||::       | |||:::.:                |.....|.|
plant   476 VPK-PSMKHFFGSNNNFSGKIPSFIC-SLRSLIIL----------------DLSNNNFSG----- 517

  Fly   471 RLPEKEGVDSSSSSE-------ISASVESSPITS--SSDPSEVDKLRDELKAVVQHFDSKFDLIF 526
            .:|...|...|:.|:       :|.|:..:.|.|  |.|.|. ::|..:|...:.||.:
plant   518 AIPPCVGKFKSTLSDLNLRRNRLSGSLPKTIIKSLRSLDVSH-NELEGKLPRSLIHFST------ 575

  Fly   527 SKLAQLNEQIQAFEVLN 543
                        .||||
plant   576 ------------LEVLN 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	6/30 (20%)
		LRR_RI	143..407	CDD:238064	73/315 (23%)
		leucine-rich repeat	143..166	CDD:275380	7/23 (30%)
		LRR_8	166..225	CDD:290566	17/59 (29%)
		leucine-rich repeat	167..190	CDD:275380	9/23 (39%)
		leucine-rich repeat	191..214	CDD:275380	4/22 (18%)
		leucine-rich repeat	215..238	CDD:275380	8/23 (35%)
		leucine-rich repeat	239..265	CDD:275380	5/25 (20%)
		leucine-rich repeat	266..325	CDD:275380	19/100 (19%)
		LRR_8	304..357	CDD:290566	15/77 (19%)
		leucine-rich repeat	326..347	CDD:275380	3/20 (15%)
		leucine-rich repeat	348..394	CDD:275380	10/45 (22%)
		LRR_8	369..428	CDD:290566	11/64 (17%)
		LRR_4	393..433	CDD:289563	12/52 (23%)
		leucine-rich repeat	395..418	CDD:275380	7/28 (25%)
RLP33	NP_187217.2	PLN00113	9..>812	CDD:331614	130/602 (22%)
		leucine-rich repeat	113..136	CDD:275380	4/29 (14%)
		leucine-rich repeat	137..160	CDD:275380	5/22 (23%)
		leucine-rich repeat	161..184	CDD:275380	6/30 (20%)
		leucine-rich repeat	185..208	CDD:275380	7/23 (30%)
		leucine-rich repeat	209..232	CDD:275380	9/23 (39%)
		leucine-rich repeat	233..256	CDD:275380	4/22 (18%)
		leucine-rich repeat	257..280	CDD:275380	8/23 (35%)
		leucine-rich repeat	281..305	CDD:275380	5/25 (20%)
		leucine-rich repeat	306..329	CDD:275380	4/22 (18%)
		leucine-rich repeat	330..354	CDD:275380	3/24 (13%)
		leucine-rich repeat	409..429	CDD:275380	3/19 (16%)
		leucine-rich repeat	430..451	CDD:275380	9/28 (32%)
		leucine-rich repeat	505..529	CDD:275380	5/44 (11%)
		leucine-rich repeat	530..551	CDD:275380	4/20 (20%)
		leucine-rich repeat	552..575	CDD:275380	7/23 (30%)
		leucine-rich repeat	576..599	CDD:275380	4/5 (80%)
		leucine-rich repeat	600..621	CDD:275380
		leucine-rich repeat	622..649	CDD:275380
		leucine-rich repeat	650..712	CDD:275380
		leucine-rich repeat	713..736	CDD:275380
		leucine-rich repeat	737..760	CDD:275380
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000