DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and lrrc15

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001074151.1	Gene:	lrrc15 / 791200	ZFINID:	ZDB-GENE-031113-8	Length:	564	Species:	Danio rerio

Alignment Length:	542	Identity:	113/542 - (20%)
Similarity:	212/542 - (39%)	Gaps:	131/542 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LVSSLEGHCQTEGKVTSCRGF-----------------------EFAGEDEKATFDLPTEVRIAE 82
            :.||....||.:.....|:||                       :.....:..||.....:.:|:
Zfish    17 VASSCPESCQCQVTKIVCQGFSVKEIPLPMPPTINALVISNTSIQSLKPSDFQTFAETLTLFVAK 81

  Fly    83 DGTTYEVGDEEHS-------RTLIFENCTFTNFPLRLFYTL------------------------ 116
            :....||  |.|:       ..|.|.....|:.|..||..|
Zfish    82 NSNITEV--EPHTFDQAFNLNALGFSGTMLTSLPDNLFQNLTALTTLTLSGNKLEVLPSSLLTPL 144

  Fly   117 -EVSELDMRGCGIRFIYWENFSIGADKLVILLLSDNHIEVLPTKTFRGAGNLEFIFLNRNKLGKL 180
             .|::||:....:..:..:.|. |.|:|.:|:|..|.|:.|.:.||:|..:|..:||.:|:|..:
Zfish   145 ANVNKLDLSKNLLSSLSEDAFR-GLDQLEMLMLQRNSIKQLHSSTFQGLSHLRSLFLQQNQLTDI 208

  Fly   181 QAGAFDNLLKLQYLDLTENRLEALAADVFAGLKSLRHVGLAGNQLTTIESDLFAHNPDLLSVAMQ 245
            .||.||:|:.|:.|.|.:|::|.|.|::||.:::|:.:.|:.|:|:.:.|.:|...|:|..:::.
Zfish   209 PAGLFDDLVNLEVLHLQDNKIEQLPANLFAKVQNLKKLYLSSNRLSLLPSGIFLSLPNLTHISLY 273

  Fly   246 NNRLREVGEYAFRSRGRHHQMQYVDLSNNPELVVLLLNINATNLTARNCSLDRVNLYGSVTNVDL 310
            :|||..:....|.:........|.:|..:.|                      .|::.::||:.|
Zfish   274 DNRLSRLMPETFGTMALQELWLYDNLLTHLE----------------------ENVFSNLTNIRL 316

  Fly   311 ---SDNRVREL---YFPASEALEHLVLRNNSLVQLASLSRVPRLRHLDVADNPNLGQLPDGWR-T 368
               |.||::.:   .|...:.|:.:.|..|.|..:.                      |..:| .
Zfish   317 LVISRNRIQYISPGAFNGLKELKEVSLHTNRLTNIE----------------------PGIFRGL 359

  Fly   369 PHLEMLVLRNTGQMELPLEALQGMQNLQKLDISGNNLTEIDPSAFPTLTQLTHFYIHGNNWNCFS 433
            |:|..:.:.|....::|::.|.|:..|..|::..|:|..:......||:.:.:..:|.|.|.|
Zfish   360 PNLANISIENNQIKQIPIQLLDGVSRLSLLEMQNNSLQNLPKDFLNTLSIVENVILHENPWRC-- 422

  Fly   434 LRNIMDVL----------IRANGIAYTVDNYDPDFPG----EYFHGIACMYRLPEKEGVDSSSSS 484
               ..|::          .:...::..:.:..|...|    |.......:..:.....||:||.:
Zfish   423 ---DQDIIPFWGWLSQHSEKVKNLSLVMCSSPPPLNGRNVRELIEDDIMVQEMTTMTTVDTSSHN 484

  Fly   485 EISASVESSP---ITSSSDPSE 503
            ..::..:..|   .|:.||..|
Zfish   485 TPASETKRPPDSNFTTISDEKE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	5/23 (22%)
		LRR_RI	143..407	CDD:238064	67/270 (25%)
		leucine-rich repeat	143..166	CDD:275380	9/22 (41%)
		LRR_8	166..225	CDD:290566	22/58 (38%)
		leucine-rich repeat	167..190	CDD:275380	10/22 (45%)
		leucine-rich repeat	191..214	CDD:275380	9/22 (41%)
		leucine-rich repeat	215..238	CDD:275380	6/22 (27%)
		leucine-rich repeat	239..265	CDD:275380	5/25 (20%)
		leucine-rich repeat	266..325	CDD:275380	11/64 (17%)
		LRR_8	304..357	CDD:290566	11/58 (19%)
		leucine-rich repeat	326..347	CDD:275380	4/20 (20%)
		leucine-rich repeat	348..394	CDD:275380	8/46 (17%)
		LRR_8	369..428	CDD:290566	13/58 (22%)
		LRR_4	393..433	CDD:289563	10/39 (26%)
		leucine-rich repeat	395..418	CDD:275380	6/22 (27%)
lrrc15	NP_001074151.1	LRRNT	21..48	CDD:214470	5/26 (19%)
		leucine-rich repeat	53..73	CDD:275380	2/19 (11%)
		LRR_RI	<163..253	CDD:238064	34/90 (38%)
		LRR_8	170..229	CDD:290566	23/58 (40%)
		leucine-rich repeat	171..194	CDD:275380	9/22 (41%)
		leucine-rich repeat	195..218	CDD:275380	10/22 (45%)
		LRR_8	218..277	CDD:290566	18/58 (31%)
		leucine-rich repeat	219..242	CDD:275380	9/22 (41%)
		LRR_4	241..280	CDD:289563	11/38 (29%)
		leucine-rich repeat	243..266	CDD:275380	6/22 (27%)
		leucine-rich repeat	267..289	CDD:275380	5/21 (24%)
		leucine-rich repeat	290..313	CDD:275380	4/44 (9%)
		LRR_8	312..372	CDD:290566	16/81 (20%)
		leucine-rich repeat	314..337	CDD:275380	5/22 (23%)
		leucine-rich repeat	338..361	CDD:275380	6/44 (14%)
		leucine-rich repeat	362..385	CDD:275380	5/22 (23%)
		TPKR_C2	418..467	CDD:301599	7/53 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.870