DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cDIP and Cpn2

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_082180.2	Gene:	Cpn2 / 71756	MGIID:	1919006	Length:	547	Species:	Mus musculus

Alignment Length:	443	Identity:	113/443 - (25%)
Similarity:	176/443 - (39%)	Gaps:	105/443 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 IVLVSSLEGHCQTEGKVTSCRGFEFAGEDEKATFDLPTEVRIAEDGTTYEVGDEEHSRTLIFENC 103
            ::|::.|...|...   ..|.|.|....||:.. |:|.::             ..|...::|...
Mouse    12 LLLLARLTQPCPVG---CDCFGREVFCSDEQLA-DIPPDI-------------PPHITDIVFVET 59

  Fly   104 TFTNFPLRLFYTLEVSELDMRGCGIRFIYWENFSIGADKLVILLLSDNHIEVLPTKTFRGAGNLE 168
            .||....|.|                     :.|....|:|.|.....|:|   ...|.|...|:
Mouse    60 AFTTVRTRAF---------------------SGSPNLTKVVFLNTQVRHLE---PDAFGGLPRLQ 100

  Fly   169 FIFLNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAADVFAGLKSLRHVGLAGNQLTTIESDLF 233
            .:.:..:.:..|.|..|.||..|:.|.|..:||..|..|:|..:..|..:.|.||||.|:...||
Mouse   101 DLEITGSPVSNLSAHIFSNLSSLEKLTLDFDRLAGLPEDLFCHMDILESLQLQGNQLRTLPGRLF 165

  Fly   234 AHNPDLLSVAMQNNRLREVGEYAFRS-RGRHHQMQYVDLSNN-----PE--------LVVLLLNI 284
            ....||.::.:..|.|.::.:.||:| .|    :|.:.||||     ||        |..|.|:.
Mouse   166 QSLRDLRTLNLAQNLLTQLPKGAFQSLTG----LQMLKLSNNMLARLPEGALGSLSSLQELFLDG 226

  Fly   285 NA-----TNLTARNCSLDR------------VNLYGSVTN---VDLSDNRVREL---YFPASEAL 326
            ||     .:|.::..||:.            |:|:.|:.|   :.|.||.:|.|   .|..::.|
Mouse   227 NAITELSPHLFSQLFSLEMLWLQHNAICHLPVSLFSSLHNLTFLSLKDNALRTLPEGLFAHNQGL 291

  Fly   327 EHLVLRNNSL--VQLASLSRVPRLRHLDVADNPNLGQLPDGWRTPHLEMLVLRNTGQM-ELPLEA 388
            .||.|..|.|  :...:.:.:.||..|.::.|. :..||:     |    |.||..|: :|.|::
Mouse   292 LHLSLSYNQLETIPEGAFTNLSRLVSLTLSHNA-ITDLPE-----H----VFRNLEQLVKLSLDS 346

  Fly   389 ----------LQGMQNLQKLDISGNNLTEIDPSAFPTLTQLTHFYIHGNNWNC 431
                      ...:..||.|::|.|.||.:....|.|...|.:..:.||.|.|
Mouse   347 NNLTALHPALFHNLSRLQLLNLSRNQLTTLPGGIFDTNYDLFNLALLGNPWQC 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	1/23 (4%)
		LRR_RI	143..407	CDD:238064	87/313 (28%)
		leucine-rich repeat	143..166	CDD:275380	6/22 (27%)
		LRR_8	166..225	CDD:290566	18/58 (31%)
		leucine-rich repeat	167..190	CDD:275380	6/22 (27%)
		leucine-rich repeat	191..214	CDD:275380	8/22 (36%)
		leucine-rich repeat	215..238	CDD:275380	9/22 (41%)
		leucine-rich repeat	239..265	CDD:275380	7/26 (27%)
		leucine-rich repeat	266..325	CDD:275380	25/94 (27%)
		LRR_8	304..357	CDD:290566	17/60 (28%)
		leucine-rich repeat	326..347	CDD:275380	6/22 (27%)
		leucine-rich repeat	348..394	CDD:275380	12/56 (21%)
		LRR_8	369..428	CDD:290566	18/69 (26%)
		LRR_4	393..433	CDD:289563	14/39 (36%)
		leucine-rich repeat	395..418	CDD:275380	9/22 (41%)
Cpn2	NP_082180.2	LRRNT	21..52	CDD:214470	9/47 (19%)
		LRR_8	73..133	CDD:290566	16/62 (26%)
		leucine-rich repeat	75..98	CDD:275380	7/25 (28%)
		LRR 1	98..119		4/20 (20%)
		leucine-rich repeat	99..122	CDD:275380	6/22 (27%)
		LRR_8	121..181	CDD:290566	20/59 (34%)
		LRR 2	122..143		8/20 (40%)
		leucine-rich repeat	123..146	CDD:275380	8/22 (36%)
		LRR 3	146..167		9/20 (45%)
		leucine-rich repeat	147..170	CDD:275380	9/22 (41%)
		LRR_RI	149..374	CDD:238064	65/238 (27%)
		LRR 4	170..191		6/20 (30%)
		LRR_8	171..229	CDD:290566	18/61 (30%)
		leucine-rich repeat	171..194	CDD:275380	6/22 (27%)
		LRR 5	194..215		8/24 (33%)
		leucine-rich repeat	195..218	CDD:275380	7/22 (32%)
		LRR_8	217..277	CDD:290566	15/59 (25%)
		LRR 6	218..239		6/20 (30%)
		leucine-rich repeat	219..242	CDD:275380	6/22 (27%)
		LRR 7	242..263		4/20 (20%)
		leucine-rich repeat	243..266	CDD:275380	4/22 (18%)
		LRR_8	266..325	CDD:290566	17/59 (29%)
		LRR 8	266..287		7/20 (35%)
		leucine-rich repeat	267..290	CDD:275380	6/22 (27%)
		LRR 9	290..311		6/20 (30%)
		leucine-rich repeat	291..314	CDD:275380	6/22 (27%)
		LRR_8	313..373	CDD:290566	18/69 (26%)
		LRR 10	314..335		8/30 (27%)
		leucine-rich repeat	315..338	CDD:275380	9/32 (28%)
		LRR 11	338..359		3/20 (15%)
		leucine-rich repeat	339..360	CDD:275380	2/20 (10%)
		LRR 12	362..383		8/20 (40%)
		leucine-rich repeat	363..382	CDD:275380	7/18 (39%)
		LRRCT	395..436	CDD:214507	3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870