DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and zgc:153913

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001073448.1	Gene:	zgc:153913 / 559700	ZFINID:	ZDB-GENE-061103-397	Length:	496	Species:	Danio rerio

Alignment Length:	566	Identity:	129/566 - (22%)
Similarity:	218/566 - (38%)	Gaps:	169/566 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 IVLVSSLEGHCQTEGKVTSCR---GFEFAGEDEK---ATFDLPTEVR---IAEDGTTYEVGDEEH 94
            :||:....|.|..|    .|:   |.:....|::   ...::.|:||   :...|.. ::..:..
Zfish    10 LVLIHLYCGVCCPE----PCQCFSGSKLVCSDDRMKSLPVNISTQVRELIVVASGIP-DLDQQSF 69

  Fly    95 SRTLIFENCTFTNFPLR-----LFYTL-EVSELDMRGCGIRFIYWENFSIGADKLVILLLSDNHI 153
            ..||......|.|..|:     .|..| |:.||::.|    .|.|.:..|
Zfish    70 PETLRLSKLVFLNGMLKSVSGEAFERLVELRELEISG----NICWMSLDI--------------- 115

  Fly   154 EVLPTKTFRGAGNLEFIFLNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAADVFAGLKSLRHV 218
                 :||....||..:.||.|||..:.||.|.:|.:|:.|.|..|.|..|:..:|..|..|:.:
Zfish   116 -----QTFSSLTNLTRLLLNNNKLSGVDAGLFHSLHQLEMLQLRGNGLSFLSGRLFQRLHRLQEL 175

  Fly   219 GLAGNQLTTIESDLFAHNPDLLSVAMQNNRLREVGEYAFRSRGRH-HQMQYVDLSNNPELVVLLL 282
            .|:.||::::.::||.:|.:|..:::|.|::..:.:..|    .| ..:|.::|.:|
Zfish   176 DLSFNQISSLSTELFQNNSELRVLSLQANKIPNLPDGIF----THLDHLQELNLRSN-------- 228

  Fly   283 NINATNLTARNCSLDRVNLYGSVTNVDLSDNRVRELYFPASEALEHLVLRNNSLVQLA------- 340
                         |.||...||               ||||  |:.|:|:.|.|.:|.
Zfish   229 -------------LIRVLTPGS---------------FPAS--LKTLILKKNLLEKLTNAVFHTL 263

  Fly   341 -----------SLSRVP--------RLRHLDVADN---PNLGQLPDGWRTPHLEMLVLRNTGQME 383
                       ||:.||        .|..||:::|   ...|.:..|..:  ::.:.|:....:.
Zfish   264 HYITYLDLSQNSLTEVPADLFQNLISLETLDLSENRISTLAGSVFKGLFS--IKSVYLQKNSLIS 326

  Fly   384 LPLEALQGMQNLQKLDISGNNLTEIDPSAFPTLTQLTHFYIHGNNWNC------------FSLRN 436
            :....|:...:||.||:|.|:|..|....|..|.....|.:.||.|:|            ::.::
Zfish   327 VDAHLLKDQHDLQLLDLSNNSLRSIPSGFFEDLDFQCVFELRGNPWSCDCGIHYFYDWLKYNHKH 391

  Fly   437 IMDV---------LIRANGIAYTVDNYDPDFPGEYFHGIACMYRLPEKEGVDSSSSSEISASVES 492
            :.|:         ||:.:.:. :||.          ..:.|        ..:|||:|....||:.
Zfish   392 VKDLSRVSCEAPELIQGHNLR-SVDR----------EQLVC--------SRNSSSNSPEMISVDE 437

  Fly   493 SPITSSSDPSEVDKLRD----ELKAVVQHFDSKFDLIFSKLAQLNE 534
            ..|..|     |.:|:.    |.| |.:..:.||...| :.|..||
Zfish   438 GSIQCS-----VQELKGTASIECK-VTKCTNVKFQAAF-QFANGNE 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	6/23 (26%)
		LRR_RI	143..407	CDD:238064	70/293 (24%)
		leucine-rich repeat	143..166	CDD:275380	2/22 (9%)
		LRR_8	166..225	CDD:290566	22/58 (38%)
		leucine-rich repeat	167..190	CDD:275380	10/22 (45%)
		leucine-rich repeat	191..214	CDD:275380	8/22 (36%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		leucine-rich repeat	239..265	CDD:275380	5/26 (19%)
		leucine-rich repeat	266..325	CDD:275380	12/58 (21%)
		LRR_8	304..357	CDD:290566	19/81 (23%)
		leucine-rich repeat	326..347	CDD:275380	10/46 (22%)
		leucine-rich repeat	348..394	CDD:275380	8/48 (17%)
		LRR_8	369..428	CDD:290566	14/58 (24%)
		LRR_4	393..433	CDD:289563	15/51 (29%)
		leucine-rich repeat	395..418	CDD:275380	10/22 (45%)
zgc:153913	NP_001073448.1	leucine-rich repeat	75..98	CDD:275380	5/22 (23%)
		LRR_RI	141..>350	CDD:238064	59/252 (23%)
		LRR_8	147..206	CDD:290566	18/58 (31%)
		leucine-rich repeat	148..171	CDD:275380	8/22 (36%)
		leucine-rich repeat	172..195	CDD:275380	7/22 (32%)
		LRR_8	194..252	CDD:290566	21/99 (21%)
		leucine-rich repeat	196..219	CDD:275380	5/26 (19%)
		leucine-rich repeat	220..241	CDD:275380	10/56 (18%)
		leucine-rich repeat	242..265	CDD:275380	6/22 (27%)
		leucine-rich repeat	266..289	CDD:275380	4/22 (18%)
		LRR_8	267..324	CDD:290566	11/58 (19%)
		leucine-rich repeat	290..313	CDD:275380	6/22 (27%)
		leucine-rich repeat	314..337	CDD:275380	2/22 (9%)
		leucine-rich repeat	338..359	CDD:275380	9/20 (45%)
		TPKR_C2	370..>404	CDD:301599	4/33 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	2	1.960