DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and 2mit

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	129/550 - (23%)
Similarity:	212/550 - (38%)	Gaps:	144/550 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 DLPTEVRIAEDG-----TTYEVG------------DE---------------EHSRTLIFENCTF 105
            |:||..|:|.:.     :..:||            ||               .|.|.|..
  Fly    33 DIPTSSRLAAEREEQQLSRQDVGRLSYQSIHRMLRDENEPDSFRGELRYQQKRHKRELEL----- 92

  Fly   106 TNFPLRLFYTLEVSELDMRGCGIRFIYWE-NFSIGADKLVILLLSDNHIEVLPTKTFRGAGNLEF 169
             |.|..   .|.::..|:|........|: :|.:    :..:.||.|.:|.|....|.....|:
  Fly    93 -NAPAN---KLNLTHRDLRTFNSTGGQWKGDFQV----ITAMDLSSNQLESLSLDNFNQLRQLD- 148

  Fly   170 IFLNRNKLGKLQAGAFDNLLKLQY--LDLTENRLEALAADVFA-GLKSLRHVGLAGNQLTTIESD 231
              |..|.|..:.....|..:.|.:  |||:.|:...::...|| .|..|:::.||.|:|..|..:
  Fly   149 --LGNNSLEVIPLSLADTNMSLPFVTLDLSCNKFSQISTSFFAQRLPQLKNLNLAHNELLNISRE 211

  Fly   232 LFAHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQYVDLSNN-------------PELVVLLLN 283
            .|.:..:|.::.:.:|.:.::....|.:.   ..:||:|||:|             |:||.|.:.
  Fly   212 SFYNLLELQTLVLSHNNISDIDYETFLAL---PNLQYLDLSHNRLSGSAIRALQGIPDLVSLSIA 273

  Fly   284 IN-----ATNLTARNCSLDRVNLYG------------SVTNVDLSDNRVREL------YFPASEA 325
            .|     |......:.||..::..|            ||..:.||||.::.:      .:|   .
  Fly   274 YNPDVGVAMQEFVASWSLKELDASGTGLCQVPAALAQSVRTLKLSDNWLKAINCGDMDSYP---L 335

  Fly   326 LEHLVLRNNSLVQLA--SLSRVPRLRHLDVADNPNLGQLPDGWRTPHLEMLVLRNTGQMELPLEA 388
            |::|.|.::.:.|:.  :|.|:..|..| ..|...|.::|.. ..|.||.|.|::...||||.:|
  Fly   336 LQYLDLSHSRIAQVEDDALGRLELLESL-FLDRNLLMRVPSS-LPPSLEHLFLQHNQIMELPPQA 398

  Fly   389 LQGMQNLQKLDISGNNLTEIDPSAFP---------------------TLTQLTHFYIHGNNWNCF 432
            ..|:.|||.||:|.|.|..:.|.:.|                     ||.||....:..|...|.
  Fly   399 FVGLVNLQTLDLSNNRLIFLPPLSLPKLLTLNLESSGVESVSQSIVHTLPQLRDLLLEDNPIKCS 463

  Fly   433 SLRNIMDVLI--------RANGIAYTVDNYDPDFPGEY--FHGI-------ACMYRLPEKEGVDS 480
            .|..|.:...        ::||.:.   :...|...||  ||..       .|..|.||.:....
  Fly   464 DLLGIAEWASPCRSVDAGQSNGASV---SGRVDLKTEYLQFHNFYENFSSRECGIRKPENDTKPP 525

  Fly   481 SSS-SEISASVESSPITSSSDPSEVDKLRD 509
            |.| :..||::.::|    ...|:|:|.::
  Fly   526 SCSLTRASATLTTTP----RSMSKVEKSQE 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	4/24 (17%)
		LRR_RI	143..407	CDD:238064	81/304 (27%)
		leucine-rich repeat	143..166	CDD:275380	6/22 (27%)
		LRR_8	166..225	CDD:290566	17/61 (28%)
		leucine-rich repeat	167..190	CDD:275380	5/22 (23%)
		leucine-rich repeat	191..214	CDD:275380	8/25 (32%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		leucine-rich repeat	239..265	CDD:275380	3/25 (12%)
		leucine-rich repeat	266..325	CDD:275380	22/94 (23%)
		LRR_8	304..357	CDD:290566	16/60 (27%)
		leucine-rich repeat	326..347	CDD:275380	6/22 (27%)
		leucine-rich repeat	348..394	CDD:275380	16/45 (36%)
		LRR_8	369..428	CDD:290566	25/79 (32%)
		LRR_4	393..433	CDD:289563	16/60 (27%)
		leucine-rich repeat	395..418	CDD:275380	11/43 (26%)
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	55/239 (23%)
		leucine-rich repeat	124..143	CDD:275380	6/18 (33%)
		leucine-rich repeat	144..167	CDD:275380	5/25 (20%)
		leucine-rich repeat	172..194	CDD:275380	7/21 (33%)
		LRR_8	193..253	CDD:290566	16/62 (26%)
		leucine-rich repeat	195..218	CDD:275380	7/22 (32%)
		leucine-rich repeat	219..242	CDD:275380	3/25 (12%)
		LRR_8	241..301	CDD:290566	15/59 (25%)
		leucine-rich repeat	243..311	CDD:275380	15/67 (22%)
		leucine-rich repeat	312..335	CDD:275380	6/25 (24%)
		LRR_8	334..415	CDD:290566	30/85 (35%)
		leucine-rich repeat	336..359	CDD:275380	6/22 (27%)
		leucine-rich repeat	360..380	CDD:275380	5/21 (24%)
		LRR_8	379..460	CDD:290566	26/80 (33%)
		LRR_4	379..>415	CDD:289563	18/35 (51%)
		leucine-rich repeat	381..404	CDD:275380	10/22 (45%)
		leucine-rich repeat	405..449	CDD:275380	11/43 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453604
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940