DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and CG7800

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_649770.1	Gene:	CG7800 / 40963	FlyBaseID:	FBgn0037552	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	128/560 - (22%)
Similarity:	207/560 - (36%)	Gaps:	159/560 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLISLAATATTDEDADADVDSGSSRIVLVSSLEGHCQ-------------TEGKVTSCRGFEFAG 65
            ||.|::|....|                   ||.:|.             ::.|.|....|....
  Fly     8 LLASVSALGRPD-------------------LEDYCNDSYCHLLGRSRTFSDKKATKLTEFHMDS 53

  Fly    66 EDEKATFDLPTEVRIAEDGTTYEVGDEEHSRTLIFENCTFTNFPLRLFYTLE-VSELDMRGCGIR 129
            .::|....:|                  :.|||..|||...:|.:.....|. ::.|.:|...:.
  Fly    54 CEKKVLKLMP------------------NLRTLELENCDSPDFTMNDLNQLPYLTSLQLRRGNLL 100

  Fly   130 FIYWENFSIGADKLVILLLSDNHIEVLPTKTFRGAGNLEFIFLNRNKLGKLQAGAFDNLLKLQYL 194
            .::.|:||...: :.||:|..|:|..|..:.|:|...|..:.|..|.:..|....|.||.:|.:|
  Fly   101 GLHDEHFSKWPN-MKILMLGGNNITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELLHL 164

  Fly   195 DLTENRLEALAADVFAGLKSLRHVGLAGNQLTTIESDLFAHNPDLLSVAMQNNRLREVGEYAFRS 259
            ||:.||:|.|..::|.|:..|..:.|.||.||.|.       |..|. ::.|.||
  Fly   165 DLSGNRIETLHENIFTGVPKLEMLLLNGNPLTWIA-------PTSLK-SLSNLRL---------- 211

  Fly   260 RGRHHQMQYVDLSNNPELVVLLLNINATNLTARNCSLDRVNLYGSVTNVDLSDNRVRELYFPASE 324
                     :|:||...|..|.|. .|..|...|..:.|:::.|||..:....|.:.|:..|...
  Fly   212 ---------LDMSNCGPLPDLSLP-GAHTLILDNSGVQRLDILGSVHKLQARKNHITEIKLPDKS 266

  Fly   325 ALEHLVLRNNSLVQLASLSRVPRLRHLDVADNPNLGQLPDGWRTPHLEMLVLRNTGQMELPLEAL 389
            ::..|.|.:|    |.:.:.:|:|                                        |
  Fly   267 SVIELDLHSN----LLTATDIPKL----------------------------------------L 287

  Fly   390 QGMQNLQKLDISGNNLTEIDPSAFPTLTQLTHFYIHGNNWNCFSLRNIMDVLIRANGIAYTVDNY 454
            .||..||:||:|.|.:.....:.....::|            |.|.|:|.:.:.||.:  |..::
  Fly   288 TGMWRLQRLDLSENIIGIYAAAGSDNTSEL------------FILPNLMYMNLSANRL--TRLHF 338

  Fly   455 DPDFPGEYFHGIACMYR---LPEKEGVDSSSSSEISASVESSPITS------SSDPSEVDKLRDE 510
            |...|.|....:...|.   .|.|.|:|.:.:.: |..:|.:.|.:      ...||
  Fly   339 DSPIPWERLTHLDASYNRIYAPAKVGIDEAFNLQ-SLHLEGNYINNFELTPWKPHPS-------- 394

  Fly   511 LKAVVQHFDSKFD-LIFSKLAQLNEQIQAFEVLNKTVWSQ 549
            ||.|.. :|:||. ..:..:.:...:| ...||.||.:||
  Fly   395 LKEVAL-YDNKFQPKGYKNITKFFNEI-GVNVLEKTQYSQ 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	5/23 (22%)
		LRR_RI	143..407	CDD:238064	68/263 (26%)
		leucine-rich repeat	143..166	CDD:275380	8/22 (36%)
		LRR_8	166..225	CDD:290566	21/58 (36%)
		leucine-rich repeat	167..190	CDD:275380	7/22 (32%)
		leucine-rich repeat	191..214	CDD:275380	10/22 (45%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		leucine-rich repeat	239..265	CDD:275380	4/25 (16%)
		leucine-rich repeat	266..325	CDD:275380	16/58 (28%)
		LRR_8	304..357	CDD:290566	11/52 (21%)
		leucine-rich repeat	326..347	CDD:275380	4/20 (20%)
		leucine-rich repeat	348..394	CDD:275380	4/45 (9%)
		LRR_8	369..428	CDD:290566	10/58 (17%)
		LRR_4	393..433	CDD:289563	7/39 (18%)
		leucine-rich repeat	395..418	CDD:275380	6/22 (27%)
CG7800	NP_649770.1	leucine-rich repeat	46..64	CDD:275380	3/35 (9%)
		leucine-rich repeat	65..85	CDD:275380	7/19 (37%)
		LRR_8	87..147	CDD:290566	16/60 (27%)
		leucine-rich repeat	89..112	CDD:275380	5/22 (23%)
		leucine-rich repeat	113..136	CDD:275380	8/22 (36%)
		LRR_RI	<131..334	CDD:238064	69/288 (24%)
		leucine-rich repeat	137..160	CDD:275380	7/22 (32%)
		LRR_8	140..195	CDD:290566	20/54 (37%)
		leucine-rich repeat	161..184	CDD:275380	10/22 (45%)
		leucine-rich repeat	185..208	CDD:275380	9/30 (30%)
		leucine-rich repeat	209..246	CDD:275380	12/56 (21%)
		leucine-rich repeat	247..267	CDD:275380	4/19 (21%)
		leucine-rich repeat	268..292	CDD:275380	9/67 (13%)
		leucine-rich repeat	293..322	CDD:275380	9/40 (23%)
		leucine-rich repeat	395..406	CDD:275378	5/11 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443094
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940