DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and Toll-9

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001246846.1	Gene:	Toll-9 / 40245	FlyBaseID:	FBgn0036978	Length:	900	Species:	Drosophila melanogaster

Alignment Length:	475	Identity:	104/475 - (21%)
Similarity:	181/475 - (38%)	Gaps:	126/475 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 KVTSCRGFEFA-----GED---------EKATFDLPTEVRIAEDGTTYEVGDEEHSRTLIFENCT 104
            |:.|.||..||     .||         .:|:..:|....:.....|.::.|.|  ..|.|.|.|
  Fly   158 KLLSLRGNNFAELIPDAEDFARFVNESRLEASNSVPHHCELLLLHNTTDLYDRE--CYLYFNNNT 220

  Fly   105 -----------FTNFPLRLFYTLEV--SELDMRGCGIRFIYWENFSIGADKLVILLLSDNHIEVL 156
                       :|||       ::|  ...|..|...:.|.|..|. ...:||.|.:|:..||.:
  Fly   221 NMGQSITTGRNYTNF-------IKVLKDRFDQHGSSSQSIAWATFP-KMPRLVELDISNCSIEYV 277

  Fly   157 PTKTFRGAGNLEFIFLNRNKLGKLQAGAFDNLLKLQYLDLTENR------------LEALAADVF 209
            ..:.||...||..:|::.||:..:....|..:..:|||||:...            || :|..:.
  Fly   278 SKEAFRNVSNLRRLFMSDNKIMTISHDTFYYVQGVQYLDLSFTNFLTYSYQLQLPTLE-MALSLI 341

  Fly   210 AGLKSLRHVGLAGNQLTTIESDLFAHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQYVDLSNN 274
            .|||              |:.::|.:.|:|:.:.:.::::......||...|  .:::::.|...
  Fly   342 YGLK--------------IQQNVFKYLPELIYLDLSHSKMTRNSAVAFAHLG--DKLKFLSLCYT 390

  Fly   275 PELVVLLLNINATNLTARNCSLDRVNLYGSVTNVDLSDNRVRELYFPASEALEHLVLRNNSLVQL 339
            ...:|       ::...:|..|:.::|.|   |..||.|.:.:.:...:..|::|....:::..|
  Fly   391 AIPMV-------SSTIFKNTVLEGLDLSG---NPYLSYNIIDDAFDGIANTLKYLYFERSNIKDL 445

  Fly   340 ASLSRVPRLRHLDVADNPNLGQLPDGWRTPHLEMLVLRNTGQMELPLEALQGMQNLQKLDISGNN 404
            .....:..|:.|.:|.| |:..|     ||.:                 .|.:::|:.||:|.|:
  Fly   446 EWSKSLKNLQVLGLAGN-NINAL-----TPAM-----------------FQSLESLEILDLSSNH 487

  Fly   405 LTEIDPSAFPTLTQLTHFYIHGNNWNCFS---LRN--------------IMDVLIRANGIAYTVD 452
            :.....|||...:.|....:..|..|..|   |::              |.|..:||.......:
  Fly   488 VGNWYRSAFHNNSALRVLNLRSNTINMLSNEMLKDFERLDYLSLGDNDFICDCHLRAVVEVAAAN 552

  Fly   453 NYDPDFPGEYFHGIACMYRL 472
            |.|.|          |.|||
  Fly   553 NKDAD----------CSYRL 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	6/25 (24%)
		LRR_RI	143..407	CDD:238064	59/275 (21%)
		leucine-rich repeat	143..166	CDD:275380	8/22 (36%)
		LRR_8	166..225	CDD:290566	17/70 (24%)
		leucine-rich repeat	167..190	CDD:275380	5/22 (23%)
		leucine-rich repeat	191..214	CDD:275380	10/34 (29%)
		leucine-rich repeat	215..238	CDD:275380	2/22 (9%)
		leucine-rich repeat	239..265	CDD:275380	4/25 (16%)
		leucine-rich repeat	266..325	CDD:275380	10/58 (17%)
		LRR_8	304..357	CDD:290566	10/52 (19%)
		leucine-rich repeat	326..347	CDD:275380	3/20 (15%)
		leucine-rich repeat	348..394	CDD:275380	9/45 (20%)
		LRR_8	369..428	CDD:290566	11/58 (19%)
		LRR_4	393..433	CDD:289563	11/39 (28%)
		leucine-rich repeat	395..418	CDD:275380	8/22 (36%)
Toll-9	NP_001246846.1	leucine-rich repeat	157..185	CDD:275380	8/26 (31%)
		LRR_8	262..322	CDD:290566	19/59 (32%)
		leucine-rich repeat	264..287	CDD:275380	8/22 (36%)
		leucine-rich repeat	288..311	CDD:275380	5/22 (23%)
		leucine-rich repeat	312..356	CDD:275380	13/58 (22%)
		LRR_8	<344..387	CDD:290566	9/58 (16%)
		leucine-rich repeat	357..381	CDD:275380	4/25 (16%)
		leucine-rich repeat	382..397	CDD:275380	2/21 (10%)
		leucine-rich repeat	405..430	CDD:275380	7/27 (26%)
		LRR_8	431..488	CDD:290566	17/79 (22%)
		leucine-rich repeat	432..453	CDD:275380	3/20 (15%)
		LRR_RI	<449..536	CDD:238064	22/109 (20%)
		leucine-rich repeat	454..477	CDD:275380	9/45 (20%)
		LRR_8	477..536	CDD:290566	13/58 (22%)
		leucine-rich repeat	478..501	CDD:275380	8/22 (36%)
		leucine-rich repeat	502..525	CDD:275380	5/22 (23%)
		TIR	751..891	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453690
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840