DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and CG4950

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	130/528 - (24%)
Similarity:	208/528 - (39%)	Gaps:	119/528 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 HSRTLIFEN--------------CTFTNFPLRLFYTLEVSELDMRGCGIRFIYWENFSIGADKLV 144
            ||:.::.:|              .|....|..||.|              |.|          |.
  Fly    57 HSQNVVIKNIPPGNMVKFMKFYESTLLYMPFHLFET--------------FPY----------LK 97

  Fly   145 ILLLSDNHIEVLPTKTFRGAGNLEFIFLNRNKLGKLQAGAFDNLLKLQYLDLTENRLEALAADVF 209
            .|.:|:.:|..|....|..|.||.::.|..|.|..:|...|.....|..|||:.|.:.:|:.:.|
  Fly    98 TLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAF 162

  Fly   210 AGLKSLRHVGLAGNQLTTIESDLFAHNPDLLSVAMQNNRLREVGEYAFRSRGRHHQMQYVDLSNN 274
            .||.::..:.|.||.|..:.:|:|..|..|..|:.:.|.|..:....||:..|   ::.|:||||
  Fly   163 CGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTSIQPEVFRNMRR---IKEVNLSNN 224

  Fly   275 PELVV-------------LLLNINAT---NLTARN----CSLDR---VNLYGSVTN-VDLSDNRV 315
            ..:.:             |:|:.|..   .||.:|    ..||.   .||..:.|. |..|.|::
  Fly   225 RLIFIHPDTFADAASLENLVLSYNELKNFQLTEKNIVHQLHLDNNYLTNLTINATRFVRASHNQI 289

  Fly   316 RELYFPASEALEHLVLRNNSLVQLASLSRVPRLRHLDVADNPNLGQLPDGW--RTPHLEMLVLRN 378
            .||:...|..:|.|.|..|.|..:::::.:..:.:|||:||| :|.|....  :...|..|.||.
  Fly   290 SELFLHQSLHIETLDLSANKLSSISNITNITHMLYLDVSDNP-IGPLNISTFSQLKRLRGLNLRG 353

  Fly   379 TGQMELPLEALQGMQNLQKLDISGNNLTEIDPSAF-PTLTQLTHFYIHG---------------- 426
            ||..||........:.|::||:|.||||.::...| |.||.|..|.|.|
  Fly   354 TGIRELKFGMFSKQKYLEELDLSFNNLTILNLDMFVPYLTNLKKFLIDGNGLTELQGNRTFSEAF 418

  Fly   427 ----------NNWNCFSLRNIMDVLIRANGIAYTVDNYDPDFPGEYFHGIACMYRLPEKEGVDSS 481
                      |.:||..|.::   ||..:.....|.|.:||            ..|.|...:
  Fly   419 PQLQKLGVSRNRFNCSYLHHL---LIPPSLPESVVLNIEPD------------TNLDETPHI--- 465

  Fly   482 SSSEISASVESSPITSSSDPSEVDKLRDELKAVVQHFDSKFDLIFSKLAQLNEQIQAFEVLNKTV 546
              .::|...:|..:.::|..:|..||..:    :|....:.|::.|....|...:...::....:
  Fly   466 --RDVSCISQSQEVVNASFTAEESKLESQ----IQMLSKQLDIVGSHSKNLELHLAFMQIFAYVM 524

  Fly   547 WSQVTLSV 554
            ...|.:.|
  Fly   525 GGLVLVGV 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	2/23 (9%)
		LRR_RI	143..407	CDD:238064	87/289 (30%)
		leucine-rich repeat	143..166	CDD:275380	7/22 (32%)
		LRR_8	166..225	CDD:290566	19/58 (33%)
		leucine-rich repeat	167..190	CDD:275380	6/22 (27%)
		leucine-rich repeat	191..214	CDD:275380	9/22 (41%)
		leucine-rich repeat	215..238	CDD:275380	7/22 (32%)
		leucine-rich repeat	239..265	CDD:275380	7/25 (28%)
		leucine-rich repeat	266..325	CDD:275380	22/82 (27%)
		LRR_8	304..357	CDD:290566	16/53 (30%)
		leucine-rich repeat	326..347	CDD:275380	5/20 (25%)
		leucine-rich repeat	348..394	CDD:275380	16/47 (34%)
		LRR_8	369..428	CDD:290566	24/85 (28%)
		LRR_4	393..433	CDD:289563	19/66 (29%)
		leucine-rich repeat	395..418	CDD:275380	11/23 (48%)
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	7/22 (32%)
		LRR_8	118..178	CDD:290566	19/59 (32%)
		leucine-rich repeat	120..143	CDD:275380	6/22 (27%)
		leucine-rich repeat	144..167	CDD:275380	9/22 (41%)
		leucine-rich repeat	168..191	CDD:275380	7/22 (32%)
		LRR_8	192..250	CDD:290566	15/60 (25%)
		leucine-rich repeat	192..215	CDD:275380	6/22 (27%)
		LRR_RI	<207..432	CDD:238064	63/228 (28%)
		leucine-rich repeat	216..239	CDD:275380	5/22 (23%)
		leucine-rich repeat	240..299	CDD:275380	17/58 (29%)
		LRR_8	299..356	CDD:290566	18/57 (32%)
		leucine-rich repeat	300..321	CDD:275380	5/20 (25%)
		leucine-rich repeat	322..345	CDD:275380	8/23 (35%)
		LRR_8	344..405	CDD:290566	24/60 (40%)
		leucine-rich repeat	346..365	CDD:275380	8/18 (44%)
		leucine-rich repeat	370..394	CDD:275380	11/23 (48%)
		leucine-rich repeat	395..420	CDD:275380	4/24 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453832
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940