DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and trn

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001261796.1	Gene:	trn / 39491	FlyBaseID:	FBgn0010452	Length:	751	Species:	Drosophila melanogaster

Alignment Length:	436	Identity:	104/436 - (23%)
Similarity:	166/436 - (38%)	Gaps:	105/436 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 KLVILLLSDNHIEVLPTKTFRGAGNLEFIFLNRNKLG------------------------KLQA 182
            :|..|.||.||:..:|.:||.....|:.:.||.||:|                        :|..
  Fly    83 ELTFLDLSSNHLMTIPQRTFAYQKKLQEVHLNHNKIGQISNKTFIGLSAVTVLNLRGNQISELHQ 147

  Fly   183 GAFDNLLKLQYLDLTENRLEALAADVFAGLKSLRHVGLAGNQLTTI-ESDLFAHNPDLLSVAMQN 246
            |.|..|||::.|:|.|||:..|....|.||..||.:.|..|.|||: :..:|...|.|..:.:..
  Fly   148 GTFTPLLKIEELNLGENRIGYLDPKAFDGLSQLRILYLDDNALTTVPDPVIFQAMPSLAELFLGM 212

  Fly   247 NRLREVGEYAFRSRGRHHQMQYVDLSNNPELVVLLLNINATNLTARNCSLDRVNLYGSVTNVDLS 311
            |.|:.:...||:           ||..       |..:.....:.||.|.|.......:..:|||
  Fly   213 NTLQSIQADAFQ-----------DLKG-------LTRLELKGASLRNISHDSFLGLQELRILDLS 259

  Fly   312 DNRVRELYFPA-----SEALEHLVLRNN--SLVQLASLSRVPRLRHLDV--------------AD 355
            |||:..:  |:     ...||.|.|..|  .::...:...:.:|:.|:|              :|
  Fly   260 DNRLDRI--PSVGLSKLVRLEQLSLGQNDFEVISEGAFMGLKQLKRLEVNGALRLKRVMTGAFSD 322

  Fly   356 NPNLGQLPDGWRTPHLEMLVL-RNTGQMELPLEALQGMQNLQKLDISGNNLTEIDPSAFPTLTQL 419
            |.|            ||.|.| .|...:|:...||.|:..|:.:.:..|.||.:....|| ...|
  Fly   323 NGN------------LEYLNLSSNKMLLEVQEGALSGLSQLKHVVLKANALTSLAEGLFP-WKDL 374

  Fly   420 THFYIHGNNWNC----FSLRNIMDVLIRANGIAYTVDNYDPDFPGEYFHG----------IACMY 470
            ....:..|..:|    ..|.|:   |:..|.....|.....:|| |...|          :.|.:
  Fly   375 QTLDLSENPLSCDCRVMWLHNL---LVAKNASQDDVSELLCEFP-ERLRGESLRHLNPAMMGCTH 435

  Fly   471 RLPEKEGVDSSSSSEISASVESSPITSSSDPSEVDKLRDELKAVVQ 516
            ..|.|:.:       |.|.:..|..|.::....:.:.|.:::..::
  Fly   436 ADPRKQAL-------IGALLVGSAATITALALVLYRCRHKIRETIK 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	104/436 (24%)
		LRR_RI	143..407	CDD:238064	81/310 (26%)
		leucine-rich repeat	143..166	CDD:275380	9/22 (41%)
		LRR_8	166..225	CDD:290566	25/82 (30%)
		leucine-rich repeat	167..190	CDD:275380	10/46 (22%)
		leucine-rich repeat	191..214	CDD:275380	9/22 (41%)
		leucine-rich repeat	215..238	CDD:275380	8/23 (35%)
		leucine-rich repeat	239..265	CDD:275380	5/25 (20%)
		leucine-rich repeat	266..325	CDD:275380	14/63 (22%)
		LRR_8	304..357	CDD:290566	16/73 (22%)
		leucine-rich repeat	326..347	CDD:275380	5/22 (23%)
		leucine-rich repeat	348..394	CDD:275380	15/60 (25%)
		LRR_8	369..428	CDD:290566	16/59 (27%)
		LRR_4	393..433	CDD:289563	9/43 (21%)
		leucine-rich repeat	395..418	CDD:275380	6/22 (27%)
trn	NP_001261796.1	leucine-rich repeat	62..80	CDD:275380
		LRR_8	83..142	CDD:290566	15/58 (26%)
		leucine-rich repeat	84..107	CDD:275380	9/22 (41%)
		leucine-rich repeat	108..131	CDD:275380	6/22 (27%)
		LRR_RI	129..421	CDD:238064	80/328 (24%)
		LRR_8	132..190	CDD:290566	19/57 (33%)
		leucine-rich repeat	132..155	CDD:275380	4/22 (18%)
		leucine-rich repeat	156..179	CDD:275380	9/22 (41%)
		leucine-rich repeat	180..204	CDD:275380	8/23 (35%)
		LRR_8	203..263	CDD:290566	18/77 (23%)
		leucine-rich repeat	205..228	CDD:275380	7/33 (21%)
		leucine-rich repeat	229..252	CDD:275380	5/22 (23%)
		LRR_8	252..308	CDD:290566	15/57 (26%)
		leucine-rich repeat	253..276	CDD:275380	7/24 (29%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		leucine-rich repeat	301..322	CDD:275380	3/20 (15%)
		LRR_8	325..384	CDD:290566	18/71 (25%)
		leucine-rich repeat	326..350	CDD:275380	9/23 (39%)
		leucine-rich repeat	351..373	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453589
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840