DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cDIP and CG5819

DIOPT Version :9

Sequence 1:	NP_650951.1	Gene:	cDIP / 42512	FlyBaseID:	FBgn0038865	Length:	554	Species:	Drosophila melanogaster
Sequence 2:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	119/518 - (22%)
Similarity:	194/518 - (37%)	Gaps:	155/518 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NC-LPFLCSYLLISLAATATTD-------------EDAD-------------ADVDS-------- 34
            || .|..|::::.||.|..:..             |..|             ||:||
  Fly    22 NCPWPCRCTWVVDSLYADCSRRSLQTYPNFDGIPVEHLDLSGNKFLEFPTLYADIDSLIYLDLSS 86

  Fly    35 ------GSSRIVLVSSLEGHCQTEGKVTSCRGFEFAGEDEKATFDLPTEVRIAEDGTTY-EVGDE 92
                  |:..::..:||.........:.|   :|....:|...: .|:..|:..||... ..|:.
  Fly    87 NYISSIGAKTLIGFTSLRTLLLANNSIDS---WESLSPNEAFKY-APSLKRLGLDGNRLGSFGNG 147

  Fly    93 EHSRTLIFENCTFTNFPLRLFYTLEVSELDMRGCGIRFIYWENFSIGADKLVILL-------LSD 150
            |.     ||          |..:..:::|.:..|||.       |||.|::|..|       |::
  Fly   148 ES-----FE----------LLTSSSLTDLGLSSCGIS-------SIGGDQMVNQLPNLERLNLAN 190

  Fly   151 N---HIEVLPTKTFR------------------GAGNLEFIFLNRNKLGKLQAGAFDNLLK---- 190
            |   .|..||::|.|                  ...|||.:.|:||.  :||   ||:|.:
  Fly   191 NQLAQIAALPSRTLRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRNT--ELQ---FDSLSEDPIL 250

  Fly   191 ---LQYLDLTENRLEALAADVFAGLKSLRHVGLAGNQLTTIESDLFAHNPDLLSVAMQNNRLREV 252
               |:.||::...|:::.   .:||..|..|.|.||.|..::.:.||:|..|..|.:..|.||.:
  Fly   251 TYMLRKLDVSYCNLDSIE---LSGLPQLTEVRLQGNLLRVVDVNTFANNSMLEVVDLSQNVLRHI 312

  Fly   253 GEYAFRSRGR-------HHQMQYVD---LSNNPELVVLLLNINATNLTARNCSLDRVNLYGSVTN 307
            |:.||....|       .:::..:|   :.||..||.|.|:.|......:..|       .||..
  Fly   313 GQDAFAKLKRLKELNLAFNEIARLDRNFIRNNDVLVELNLSRNVLQKLTKIVS-------NSVRT 370

  Fly   308 VDLSDNRVRELYFPASEAL---EHLVLRNNSLVQLASLSRVPRLRHLDVADNPNLGQLPDGWRTP 369
            :::|...:..:...|..:|   :.|.|.||.:..:.:..|...|:.|::|
  Fly   371 INMSWCEITSIESTALSSLSVIQKLDLSNNLITDMPTFMRSETLQQLNLA--------------- 420

  Fly   370 HLEMLVLRNTGQMELPLEALQGMQNLQKLDISGNNLTE-IDPSAFPTLTQLTHFYIHGNNWNC 431
            :..:..:||....|.|        .|..|.::||.||. |.|:.|.....|...::..|.|.|
  Fly   421 NCRLTTVRNNTFREFP--------ELADLHLNGNRLTSPIPPNYFDGNKFLDQLWLGDNPWIC 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cDIP	NP_650951.1	leucine-rich repeat	118..142	CDD:275380	7/23 (30%)
		LRR_RI	143..407	CDD:238064	75/311 (24%)
		leucine-rich repeat	143..166	CDD:275380	9/50 (18%)
		LRR_8	166..225	CDD:290566	22/65 (34%)
		leucine-rich repeat	167..190	CDD:275380	10/22 (45%)
		leucine-rich repeat	191..214	CDD:275380	6/22 (27%)
		leucine-rich repeat	215..238	CDD:275380	9/22 (41%)
		leucine-rich repeat	239..265	CDD:275380	9/32 (28%)
		leucine-rich repeat	266..325	CDD:275380	13/61 (21%)
		LRR_8	304..357	CDD:290566	13/55 (24%)
		leucine-rich repeat	326..347	CDD:275380	6/23 (26%)
		leucine-rich repeat	348..394	CDD:275380	7/45 (16%)
		LRR_8	369..428	CDD:290566	14/59 (24%)
		LRR_4	393..433	CDD:289563	13/40 (33%)
		leucine-rich repeat	395..418	CDD:275380	9/23 (39%)
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	4/21 (19%)
		LRR_RI	<58..236	CDD:238064	41/203 (20%)
		LRR_8	78..141	CDD:290566	11/66 (17%)
		leucine-rich repeat	79..102	CDD:275380	1/22 (5%)
		leucine-rich repeat	103..130	CDD:275380	4/30 (13%)
		leucine-rich repeat	131..155	CDD:275380	8/38 (21%)
		LRR_8	156..214	CDD:290566	17/64 (27%)
		leucine-rich repeat	158..182	CDD:275380	10/30 (33%)
		LRR_8	202..285	CDD:290566	24/90 (27%)
		leucine-rich repeat	204..227	CDD:275380	1/22 (5%)
		leucine-rich repeat	254..274	CDD:275380	6/22 (27%)
		LRR_8	273..333	CDD:290566	18/59 (31%)
		leucine-rich repeat	275..298	CDD:275380	9/22 (41%)
		LRR_RI	277..>471	CDD:238064	53/223 (24%)
		leucine-rich repeat	299..322	CDD:275380	8/22 (36%)
		LRR_8	321..402	CDD:290566	19/87 (22%)
		leucine-rich repeat	323..346	CDD:275380	3/22 (14%)
		leucine-rich repeat	347..391	CDD:275380	11/50 (22%)
		leucine-rich repeat	392..413	CDD:275380	5/20 (25%)
		LRR_8	393..448	CDD:290566	16/77 (21%)
		leucine-rich repeat	414..437	CDD:275380	7/45 (16%)
		LRRCT	471..517	CDD:214507	3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010